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Intrinsically disordered proteins are involved in many biological processes such as signaling, regulation, and recognition. A common strategy to regulate their function is through phosphorylation, as it can induce changes in conformation, dynamics, and interactions with binding partners. Although phosphorylated intrinsically disordered proteins have received increased attention in recent years, a

Analyses of the future for manufacturing and heavy industries in a climate constrained world many times focus on technological innovations in the early stages of the value chain, assuming few significant changes are plausible, wanted, or necessary throughout the rest of the value chain. Complex questions about competing interests, different ways of organising resource management, production, consu

The location of the West African craton (WAC) has been poorly constrained in the Paleoproterozoic–Mesoproterozoic supercontinent Nuna (also known as Columbia). Previous Nuna reconstruction models suggested that the WAC was connected to Amazonia in a way similar to their relative position in Gondwana. By an integrated paleomagnetic and geochronological study of the Proterozoic mafic dikes in the An

Understanding N budgets of tundra ecosystems is crucial for projecting future changes in plant community composition, greenhouse gas balances and soil N stocks. Winter warming can lead to higher tundra winter nitrogen (N) mineralization rates, while summer warming may increase both growing season N mineralization and plant N demand. The undulating tundra landscape is inter-connected through water

Much of the income equalization that took place during the first half of the twentieth century was driven by shifts in the shares of the incomes of the rich, such as the top 1 percent. But the available studies using tabulated data have not been wholly able to account for the relative decline in top earners’ incomes. In this paper, we present the first evidence on the composition of the top groups

The aim of the present study was to estimate the range of climate variability in Central Poland during the Eemian Interglacial (MIS 5e). High resolution pollen records are available for all seven RPAZs typical of this interglacial in Central Europe. These pollen records were used to estimate total annual precipitation and mean annual temperature, as well as the mean temperatures of the warmest and

Hereditary CNS amyloid angiopathy occurring in Icelanders is the first human disorder known to be caused by deposition of cystatin C amyloid fibrils in the walls of the brain arteries leading to single or or multiple strokes with fatal outcome. One or more affected members have been verified by histological examination in 8 families containing 127 affected. These originated from the same geographi

The anodic corrosion behavior of 50 Å thick single-crystalline IrO2(110) films supported on slightly bulk-reduced TiO2(110) single crystals is studied during acidic water splitting by a unique combination of operando techniques, namely, synchrotron-based high-energy X-ray reflectivity (XRR) and surface X-ray diffraction (SXRD) together with highly sensitive inductively coupled plasma mass spectrom

To determine the prevalence of renal amyloidosis of the AA-type in a defined population, formalin-fixed specimens from the kidneys of all the cases autopsied in 1983 at The General Hospital of Malmö, Sweden, were investigated using immunohistochemical techniques. Amyloid deposits of protein AA were found in 10 of 1,158 investigated cases and the calculated prevalence was 0.86 per cent. The mean ag

To examine whether sequence-specific antibodies directed against serum amyloid A were useful in the demonstration and classification of amyloidosis, needle biopsy specimens from the kidneys of 152 cases with renal disorders were investigated using the avidin-biotin-peroxidase complex technique of immunohistochemistry. A distinct immunoreactivity of protein AA was seen in biopsies from all 42 indiv

We investigate if Marine Stewardship Council (MSC) certified Norway lobster fishing vessels inSweden got higher prices and sold larger quantities after certification was introduced in 2015. Usingdetailed daily panel data and exploiting the fact that the same fishing water contains both certified andnon-certified vessels, we use a difference-in-difference model for analysing demand effects of MSCce

We investigated the effect of Aztreonam on hydrolysis of β-lactam antibiotics by MBL using New Delhi Metallo-β-lactamase-1(NDM-1) as a model. The results showed that Aztreonam significantly inhibited hydrolysis of Nitrocefin and Meropenem by soluble NDM-1, but also inhibited hydrolysis of Penicillin G by CPG beads immobilized NDM-1(NDM-1 beads). Moreover, in spite of extensive washing for multiple

Polisen bör lära av USA och centralisera sin kamp emot gängkriminaliteten. Ett nationellt centrum med denna huvuduppgift kan vara en början till slutet för gängen, skriver Ardavan Khoshnood som är docent i akutsjukvård vid Lunds universitet samt kriminolog och statsvetare.The police should learn from the United States and centralize their fight against gang criminality. A national center with this main task can be a beginning to the end for the gangs, writes Ardavan Khoshnood who is an associate professor of Emergency Medicine at Lund University and a criminologist and political scientist.

The penicillinase thermistor biosensor（Penicillinase sensor） was developed for the rapid monitoring of blood penem antibiotics concentration and rapid identification of extraneous penicillinase in milk on site.However, the wide application of the penicillinase thermistor biosensor was limited due to its intrinsic poor activity to hydrolyze cephem and carbapenem antibiotics.The recently identified

Objective To compare the enzyme thermistor bioanalysis equipment with blood glucose meter which is analyzed by automatic biochemical analyzer, validate the correct rate of this equipment. The long-term aim of the project was to develop a prototype for a bedside monitor system for semi-continuous monitoring of the blood glucose concentration. This was made possible by using the special advantage of

Methyl parathion hydrolase （ MPH ） as and bovine serum albumin （BSA） as hybrid proteins, the target protein, bovine hemoglobin （BHb）, myoglobin （Mb） enzyme thermal analysis was used to determine the best separation condition of methyl parathion hydrolase through the study of pH and the NaC1 concentration in mobile phase. The results showed that at pH 8.0, NaC1 concentration of 0.8 mol/L, the separ