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Free, complexed, and total serum prostate-specific antigen concentrations and their proportions in predicting stage, grade, and deoxyribonucleic acid ploidy in patients with adenocarcinoma of the prostate

Objectives. Nearly half of men with clinically localized prostate cancer are understaged. We evaluated whether knowledge of preoperative free prostate-specific antigen (f-PSA), complexed (c-PSA), and total (t-PSA) concentrations or the ratios thereof (f-PSA/t-PSA, c-PSA/t PSA, and f PSA/c- PSA) could improve upon the staging of prostate cancer when compared with standard PSA testing (t-PSA). In ad

Structure and function of prostatic- and seminal vesicle-secreted proteins involved in the gelation and liquefaction of human semen

At ejaculation, the epididymal spermatozoa mix with the secretions produced by the seminal vesicles and the prostate. The glandular secretions immediately turns into a gel-like structure which entraps the spermatozoa. The ejaculated spermatozoa become progressively motile as the gel dissolves. The discovery, structure, and interactions of proteins involved in these post-ejaculatory phase reactions

Structure of SpoT reveals evolutionary tuning of catalysis via conformational constraint

Stringent factors orchestrate bacterial cell reprogramming through increasing the level of the alarmones (p)ppGpp. In Beta- and Gammaproteobacteria, SpoT hydrolyzes (p)ppGpp to counteract the synthetase activity of RelA. However, structural information about how SpoT controls the levels of (p)ppGpp is missing. Here we present the crystal structure of the hydrolase-only SpoT from Acinetobacter baum

An improved estimation of soil water and salt dynamics by considering soil bulk density changes under freeze/thaw conditions in arid areas with shallow groundwater tables

Soil bulk density (BD) is a parameter dependent on soil texture, compositions of soil minerals and organic matter and the extent of soil compaction. Seasonal freeze/thaw in arid areas with shallow groundwater tables (AASGT) may significantly change BD and hence soil hydrothermal properties and water holding capacity. Therefore, quantifying soil bulk density changes (BDC) under freeze/thaw conditio

Existential Sustainability: An investigation of Loneliness and Belonging in Relation to Sustainable Housing

The strive to create sustainable societies is often addressed through the lens of social, economic-, or environmental sustainability. However, this division fails to acknowledge existential dimensions of sustainability, i.e., the fundamental concern to sustain a good and meaningful life. This paper expands the notion of Existential Sustainability in relation to socio-material dimensions and built The strive to create sustainable societies is often addressed through the lens of social, economic-, or environmental sustainability. However, this division fails to acknowledge existential dimensions of sustainability, i.e., the fundamental concern to sustain a good and meaningful life. This paper expands the notion of Existential Sustainability in relation to socio-material dimensions and built

Deep Reinforcement Learning for Active Human Pose Estimation

Most 3d human pose estimation methods assume that input – be it images of a scene collected from one or several viewpoints, or from a video – is given. Consequently, they focus on estimates leveraging prior knowledge and measurement by fusing information spatially and/or temporally, whenever available. In this paper we address the problem of an active observer with freedom to move and explore the