PCR of TCR/Ig gene rearrangements is considered the method of choice for minimal residual disease (MRD) quantification in BCP-ALL, but flow cytometry analysis of leukemia-associated immunophenotypes (FCM-MRD) is faster and biologically more informative. FCM-MRD performed in 18 laboratories across seven countries was used for risk stratification of 1487 patients with BCP-ALL enrolled in the NOPHO A

Different methods can be used to define healthy vascular ageing (HVA). In this prospective cohort study, we explored three different definitions in order to provide guidance for which to use. 2718 subjects were included from the Cardiovascular (CV) arm of the Malmö Diet Cancer Study (MDCS; median age 71.9 years, 62.2% females). Three different definitions of HVA were used: HVA-1 (

Carbon release from the North Pacific in glacial-interglacial cycles has been mainly linked to the North Pacific Intermediate Water (NPIW) formation and associated carbon/nutrient water upwelling and biological productivity changes. However, relationship between NPIW and atmospheric CO2 change in the early interglacial remains unclear. Here we report a high-resolution sediment record of NPIW evolu

Vegetation is an important component in the Earth system, providing a direct link between the biosphere and atmosphere. As such, a representative vegetation pattern is needed to accurately simulate climate. We attempt to model global vegetation (biomes) with a data-driven approach, to test if this allows us to create robust global and regional vegetation patterns. This not only provides quantitati

A sociocultural perspective was utilized to explore if concept mapping using macroscopic, symbolic and submicroscopic aspects (often referred to as the ‘chemistry triplet’) can be used to promote development of expert knowledge in secondary school chemistry students by facilitating multilevel thinking. An additional aim was to explore the possibilities of using sociocultural theory to study the de

The distribution of heavy metal concentrations and related human health risks were investigated for Shimabara City, Nagasaki Prefecture. The purpose was to clarify the potential for heavy metal contamination in an area already known to be affected by nitrate pollution. A total of 188 soil samples was collected at 47 sites. The heavy metal content of the soil was measured in laboratory using an X-r

The COVID-19 pandemic has provoked generalized uncertainty around the world, with health workers experiencing anxiety, depression, burnout, insomnia, and stress. Although the effects of the pandemic on mental health may change as it evolves, the majority of reports have been web-based, cross-sectional studies. We performed a study assessing acute stress in frontline healthworkers during two consec

Denna artikel är den första i en serie om två artiklar som introducerar astrobiologins filosofi. Detta är ett förhållandevis nytt och i Sverige nästan okänt forskningsfält som dock befinner sig i snabb tillväxt internationellt. Ämnet presenteras här i form av exempel på några centrala frågeställningar inom området. I den här artikeln presenteras några frågeställningar hemma-hörande i teoretisk fil

Denna artikel är den andra i en serie om två artiklar som introducerar astrobiologins filosofi. Detta är ett förhållandevis nytt och i Sverige nästan okänt forskningsfält som dock befinner sig i snabb tillväxt internationellt. Ämnet presenteras här i form av exempel på några centrala frågeställningar inom området. I den här artikeln presenteras några frågeställningar hemma-hörande i praktisk filos

Differences between 10Be records from Greenland and Antarctica over the last 100 years have led to different conclusions about past changes in solar activity. The reasons for this disagreement remain unresolved. We analyze a seasonally resolved 10Be record from a firn core (North Greenland Eemian Ice Drilling [NEEM] ice core project) in Northwestern Greenland for 1887–2002. By comparing the NEEM d

While the traditional consensus dictates that high ion concentrations lead to negligible long-range electrostatic interactions, we demonstrate that electrostatic correlations prevail in deep eutectic solvents where intrinsic ion concentrations often surpass 2.5 M. Here we present an investigation of intermicellar interactions in 1:2 choline chloride:glycerol and 1:2 choline bromide:glycerol using

The optical resonance between an absorbing particle and the trapping laser can enhance the radiation force exerted on micro/nanoscale objects. However, the exact mechanism behind this resonance is still elusive. To unravel the phenomenon, we studied the resonance between a single dye-doped polystyrene particle and a 1064 nm trapping laser under specifically designed optical conditions. The dye-dop

Planetary protection is not just a matter of science. It is also a matter of value. This is so independently of whether we only include the protection of science or if we also include other goals. Excluding other values than the protection of science is thus a value statement, not a scientific statement and it does not make planetary protection value neutral. It just makes the axiological basis (t