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The Influence from SCMs on Salt Frost Scaling of Concrete Structures - Minimum Required Air Content and effect from Carbonation

The goal for this PhD thesis is to evaluate the effect different SCMs has on the salt frost scaling resistance regarding air content required in well hydrated carbonated and non-carbonated concrete which contains admixtures. To evaluate this, freeze-thaw scaling tests, image analysis of the air void structure in hardened concrete, measurements with an air void analyser and low-temperature calorime

Dancing on the borders of article 4. Human trafficking and the European Court of Human Rights in the Rantsev case

Abstract in UndeterminedThis article points to four worrisome aspects of the Court’s reasoning in Rantsev v. Cyprus and Russia. First, the Court takes on board the concept of ‘human trafficking’ without offering any meaningful legal analysis as to the elements of the human trafficking definition. Second, the adoption of the human trafficking framework implicates the ECtHR in anti-immigration and a

Autoantibodies against modified apolipoprotein B-100 in relation to low-density lipoprotein size and the metabolic syndrome in otherwise healthy men

The role of inflammation in atherosclerotic disease is well established, but the role of autoantibodies against modified apolipoprotein (apo) B-100 remains unclear. The metabolic syndrome is associated with a proinflammatory state, a predominance of small dense low-density lipoprotein (LDL) particles, and an increased risk for atherosclerotic diseases. Previous studies have shown specific autoanti

Mechanistic-Empirical Modeling of Permanent Deformation in Asphalt Concrete Layers

Popular Abstract in Swedish De allra flesta av oss bilister har någon gång kört på en väg med tydliga spår i vägytan. Man märker tydligt hur både komforten och säkerheten minskar eftersom möjligheten att styra fordonet försämras. Dessutom försämras trafiksäkerheten ytterligare när regn eller snö ansamlas och orsakar vattenplaning eller halka. Därför får de gradvis framväxande spåren inte bli för dThree mechanistic-empirical permanent deformation models were evaluated under Swedish conditions with respect to traffic, climate and materials using accelerated pavement testing and long-term pavement performance studies. The mechanistic-empirical pavement design guide (M E PDG), the incremental-recursive mechanistic-empirical CalME model (CalME), and the PErmanent Deformation of asphalt concrete

An upgrade of the internal dosimetry computer program IDAC

A full update of the internal dosimetry computer program IDAC has been conducted. The new update is based on new and more accurate computational phantoms to calculate effective dose and absorbed dose to organs and tissues. The new ICRP Adult Reference Computational Phantoms has been adopted as well as the latest of the ICRP standardized biokinetic models. The updated computer program includes a us

Metaforerna och Rätten

Denna artikel visar hur kognitiv teori gällande metaforer och tankestrukturer kan justeras och sammanjämkas med valda delar av samhällsvetenskaplig teori, i syfte att bidra till rättslig analys och en rättssociologisk förståelse av rätten. Artikeln betonar därmed vikten av en metaforanalys i syfte att kartlägga de underliggande tankestrukturer som konstruerar en specifik rättslig norm. Detta betyd

Early Cardiovascular Changes of Familial Hypertrophic Cardiomyopathy in the Young

Popular Abstract in Swedish Populärvetenskaplig sammanfattning Familjär hypertrof kardiomyopati (HCM) är den vanligaste ärftliga hjärtsjukdomen som ärvs autosomalt dominant, dvs. ca 50% risk för varje barn i den drabbade familjen. Tidigare studier har visat hög risk för HCM relaterade tillbud inklusive plötslig hjärtdöd (SCD) under barndomen, med en incidens upp till 10 % under de två första decenFamilial hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease, transmitted in an autosomal dominant fashion, i.e. 50% risk for transmission of the disease-causing mutation to each child of the affected family. Previous studies reveal a high risk for HCM related cardiac events including sudden cardiac death (SCD) during childhood, with a peak incidence of up to 10% during th

The impact of statins on psychological wellbeing: a systematic review and meta-analysis

Background: Cholesterol-lowering medications such as statins have anti-inflammatory and antioxidant properties, which may be beneficial for treating depression and improving mood. However, evidence regarding their effects remains inconsistent, with some studies reporting links to mood disturbances. We aimed to conduct a meta-analysis to determine the impact of statins on psychological wellbeing of

FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes.

Human adipocytes express high levels of two distinct lipid droplet proteins, fat specific protein 27 (FSP27; also called CIDEC), a member of the CIDE family, and perilipin1 (PLIN1), a member of the PAT family. Both proteins play a role in fat metabolism in adipocytes, but how they interact is not known. Our present study demonstrates that FSP27 and PLIN1 co-localize and interact in cultured human

HIV disease progression - Impact of HIV-1 intersubtype recombination and association with HIV-2 evolution

Human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) are both causative agents of AIDS, with similar pathogenic characteristics. However, the rate of disease progression is highly variable both within and between HIV-1 and HIV 2, but the mechanisms involved in modulating the rate of disease progression remain poorly understood. Host genetics account for some of the variation within each

Structural and biochemical characterization of two heme binding sites on α1-microglobulin using site directed mutagenesis and molecular simulation.

α1-Microglobulin (A1M) is a reductase and radical scavenger involved in physiological protection against oxidative damage. These functions were previously shown to be dependent upon cysteinyl-, C34, and lysyl side-chains, K(92, 118,130). A1M binds heme and the crystal structure suggests that C34 and H123 participate in a heme binding site. We have investigated the involvement of these five residue

Feasibility Study of Ubiquitous Interaction Concepts

There are all sorts of consumer electronics in a home environment. Using ”apps” to interact with each device is neither feasible nor practical in an ubicomp future. Prototyping and evaluating interaction concepts for this future is a challenge. This paper proposes four concepts for device discovery and device interaction implemented in a virtual environment. The interaction concepts were compared

Detection of elemental mercury by multimode diode laser correlation spectroscopy

We demonstrate a method for elemental mercury detection based on correlation spectroscopy employing UV laser radiation generated by sum-frequency mixing of two visible multimode diode lasers. Resonance matching of the multimode UV laser is achieved in a wide wavelength range and with good tolerance for various operating conditions. Large mode-hops provide an off-resonance baseline, eliminating int

Risk of Asthma in Young Adults Who Were Born Preterm: A Swedish National Cohort Study

OBJECTIVE: Preterm birth is associated with asthma-like symptoms in childhood and possibly in adolescence, but the longer-term risk of asthma is unknown and increasingly relevant as larger numbers of these individuals enter adulthood. Our objective was to evaluate whether those who were born preterm are more likely to be prescribed asthma medications in young adulthood than those who were born ter

ABCA1 upregulating apolipoproein M expression mediates via the RXR/LXR pathway in HepG2 cells

We have previously reported that liver X receptor (LXR) agonist, TO901317, could significantly inhibit hepatic apolipoprotein M (apoM) expression. It has been reported that TO901317 could activate the ATP-binding cassette transporter A1 (ABCA1) that mediates cholesterol efflux to the lipid-poor apoA1, which is an essential step for the high-density lipoprotein (HDL) formation. It is unknown if ABC