With the shift of focus of the regulatory bodies, from fixed process conditions towards flexible ones based on process understanding, model-based optimization is becoming an important tool for process development within the biopharmaceutical industry. In this paper, a multi-objective optimization study of separation of three insulin variants by reversed-phase chromatography (RPC) is presented. The

The operating range in HCCI mode is limited by the excessive pressure rise rate and therefore high combustion induced noise. The HCCI range can be extended with turbocharging which enables increased dilution of the charge and thus a reduction of combustion noise. When the engine is turbocharged the intake charge will have a high temperature at increased boost pressure and can then be regulated in The operating range in HCCI mode is limited by the excessive pressure rise rate and therefore high combustion induced noise. The HCCI range can be extended with turbocharging which enables increased dilution of the charge and thus a reduction of combustion noise. When the engine is turbocharged the intake charge will have a high temperature at increased boost pressure and can then be regulated in

An experimental analysis of the fire behavior of stone wool composites with stainless steel and gypsum plasterboard linings was performed. The focus was to characterize the micro-scale behavior of stone wool, and identify the main processes occurring in stone wool composites when exposed to heat. Thermogravimetric analysis was applied to two different wools with varying densities and binder conten

Combination of right EGR rates with turbocharging has been identified as a promising way to increase the maximum load and efficiency of heavy duty spark-ignited natural gas engines. With stoichiometric conditions a three way catalyst can be used which means that regulated emissions can be kept at very low levels. However dilution limit is limited in these types of engines because of the lower burnCombination of right EGR rates with turbocharging has been identified as a promising way to increase the maximum load and efficiency of heavy duty spark-ignited natural gas engines. With stoichiometric conditions a three way catalyst can be used which means that regulated emissions can be kept at very low levels. However dilution limit is limited in these types of engines because of the lower burn

Endothelial progenitor cells (EPCs) contribute to neovasculogenesis and reendothelialization of damaged blood vessels to maintain the endothelium. Dysfunction of EPCs is implicated in the pathogenesis of vascular injury induced by homocysteine (Hcy). We aimed to investigate the role of Cyclin A in Hcy-induced EPCs dysfunction and explore its molecular mechanism. In this study, by treatment of EPCs

Assessment of neurologic prognosis after cardiac arrest. Updated recommendations from the Swedish CPR Council Expert Group European Resuscitation Council (ERC) issued updated guidelines for postresuscitation care in 2015. This paper provides updated Swedish recommendations for neurological prognostication of patients remaining unconscious after cardiac arrest (CA). The prognostication should be ba

Coupled one-dimensional (1D) sewer and two-dimensional (2D) overland flow hydrodynamic models were constructed to evaluate the flood mitigation efficiency of a renowned blue-green stormwater retrofit, i.e. Augustenborg, in Malmö, Sweden. Simulation results showed that the blue-green stormwater systems were effective in controlling local surface flooding in inner-city catchments, having reduced the

In the study presented in this paper a single-cylinder Scania D12 diesel engine has been converted to work as a pneumatic hybrid. During pneumatic hybrid operation the engine can be used as a 2-stroke compressor for generation of compressed air during vehicle deceleration and during vehicle acceleration the engine can be operated as an air-motor driven by the previously stored pressurized air.The

An adamantinous craniopharyngioma (CP) is rare benign pituitary tumour often growing invasively and thereby affecting the hypothalamus. The recurrence rate in CP is high and therapy of choice is surgery, followed by cranial radiotherapy (CRT) in about half of the patients. Patients with CP have a 3-19 fold higher cardiovascular mortality in comparison to the general population. The majority of pat

Partially Premixed Combustion (PPC) has shown its potential by combining high combustion controllability with emission characteristics that are close to those of an HCCI engine. In order to get PPC the ignition delay needs to be long enough for the fuel and air to mix prior to combustion. This can be achieved by injecting the fuel sufficiently early while running with high EGR.In order to find outPartially Premixed Combustion (PPC) has shown its potential by combining high combustion controllability with emission characteristics that are close to those of an HCCI engine. In order to get PPC the ignition delay needs to be long enough for the fuel and air to mix prior to combustion. This can be achieved by injecting the fuel sufficiently early while running with high EGR.In order to find out