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The aim of this study was to assess the frequency and prognostic value of TP53 gene somatic mutations in non-small cell lung cancer. The study group included 240 NSCLC patients who underwent pulmonary resection at the Department of Thoracic Surgery, Medical University of Gdansk. Tumour samples were evaluated for the presence of TP53 gene mutations in exons 5-8. In 157 cases SSCP method was used as
Popular Abstract in Swedish Denna avhandling handlar om en grupp narkotikamissbrukare som gjort självmordsförsök. Såväl självmord som självmordsförsök är betydligt vanligare bland narkotikamissbrukare jämfört med totalbefolkningen. Bland vårdade narkotikamissbrukare är det mellan 19 till 47 procent som gjort självmordsförsök. Det höga självmordsförsökstalet bland narkotikamissbrukare förklaras oftThe aim of this thesis is to describe suicide attempts in a group of drug abusers who previously had received treatment of their addiction. Another aim is to interpret and analyse the life situations that the individual associates with the suicide attempt. The dissertation is based on interviews conducted on two occasions with 92 drug abusers, 62 men and 30 women. The majority of the drug abusers
Housing of animals in an enriched environment (EE) has many positive effects on brain structure and function and can facilitate recovery from various brain injuries. The purpose of this study was to evaluate whether enriched rearing could alter the stress response induced by repeated immune challenge and to investigate the influence of EE and immune challenge on glutamate receptor gene expression
Objective: To investigate the associations between psychosocial conditions at work, social capital/social participation, and daily smoking. Design/setting/participants/measurements: The 2000 public health survey in Scania is a cross sectional postal questionnaire study with a 59% participation rate. A total of 5180 persons aged 18–64 years that belonged to the work force and the unemployed were i
A method for the determination of 5-hydroxy-N-methyl-2-pyrrolidone (5-HNMP) and 2-hydroxy-N-methylsuccinimide (2-HMSI) in plasma was developed. 5-HNMP and 2-HMSI are metabolites to the widely used organic solvent N-methyl-2pyrrolidone (NMP). The 5-HNMP and 2-HMSI were purified from plasma by C8 solid phase extraction, derivatised by bistrimethylsilyl trifluoroacetamid, and analysed by gas chromato
BACKGROUND: Hippocampal decrease in size in response to posttraumatic stress disorder (PTSD) is still a subject of controversy. The aims of this study were to: (1) confirm previous hippocampus findings in PTSD patients compared to controls, using ethnically similar study groups where alcohol and drug abuse were non-existent; (2) test influence of disease duration as well as depression scores on po
The dissertation is confined to the formal work of the boards of the parent companies as recorded in the approved minutes of meetings at Alfa Laval AB, Atlas Copco AB and Kockums Mekaniska Verkstads AB and is based on the Companies Law applying in Sweden since 1848. The study covers the time from the establishment of the joint stock company up to the ordinary general meeting of 1980 (1979 in the c
It was recently shown that prostacyclin at a low dose reduces cortical cell death following brain trauma in the rat. Conceivably, prostacyclin with its vasodilatory, anti-aggregatory, anti-adhesive and permeability-reducing properties improved a compromised perfusion caused by post-traumatic vasoconstriction, microthrombosis and increased microvascular permeability. The objective of the present st
Despite the benefits of currently available preventative and therapeutic interventions, atherosclerotic vascular disease continues to be a major cause of morbidity and mortality in much of the Western World. This emphasize,,, the need for additional preventive and therapeutic interventions exploiting new targets to compliment and augment the results of LDL lowering and other current strategies. On
The contraction of smooth muscle is influenced by the substrate MgATP and the product MgADP. The effects on force, shortening velocity and ATP-turnover, are consistent with an influence on the kinetics of cross-bridge cycling. Part of these effects are mediated via an influence on the regulation of contraction by myosin light chain phosphorylation. Results from preparations activated by thiophosph
We evaluated the durability of autologous chondrocyte transplantation grafts in 61 patients treated for isolated cartilage defects on the femoral condyle or the patella and followed up for a mean of 7.4 years (range, 5 to 11). Durability was determined by comparing the clinical status at the long-term follow-up with that found 2 years after the transplantation. After 2 years, 50 of the 61 patients
