För kemister världen över är neurologiska och psykiatriska sjukdomar viktiga forskningsområden. Den ökande efterfrågan på läkemedel som kan hjälpa mot dessa sjukdomar är en växande utmaning. Därför har vi i detta projekt valt att arbeta med en typ av receptor i hjärnan som är involverad i många av dessa sjukdomar, nämligen NMDA-receptorer. Man kan jämföra NMDA-receptorer med de tre skandinaviska sNMDA receptors are ligand-gated ion channels assembled as heterotetramers composed of glycine-binding GluN1 and GluN3 subunits (GluN3A-B), and glutamate-binding GluN2 subunits (GluN2A-D). Their involvement in various psychiatric and neurological disorders makes them potential therapeutic targets. However, compared to the extensively studied GluN1/2 NMDARs, the functional, physiological, and pharma

As Sweden expands and modernizes its railway network, the design of durable and cost- efficient railway bridges becomes increasingly important. A central technical challenge in this context is track-bridge interaction (TBI), the mechanical interplay between the rail and bridge structure. This interaction affects how forces from traffic loads, temperature variations and braking are transferred with

The present study investigated the kinetic stability and activity of water-forming NAD(P)H oxidase (NOX) in a Liebig-type bubble column reactor, simulating industrial-scale conditions at laboratory scale. The study is divided into three parts, examining hydrodynamic parameters, NOX deactivation rate and protein concentration dynamics. The first part investigated and characterized the hydrodynamic

In 1966, National Librarian Uno Willers expressed concerns about the condition of Sweden’s four legal deposit copies intended for long-term preservation. Since then, access has improved, internal library work has changed due to technological and societal developments, and the responsibility for long-term preservation has been reduced to two libraries – the National Library (KB) and Lund University

This master’s thesis concerns the problem of how subject teachers go about the task of basing their teachings on research knowledge, as it is stated for them in the Swedish education act. Some challenges for teachers lie in staying up to date with relevant research-based findings in all the areas that the teaching profession encompasses and orienting themselves in an overwhelming and complex infor

During the last ten years, many reports have highlighted the increasingly stressed working environment in Swedish public libraries. Librarians are experiencing elevated stress levels and encountering various forms of disorder in their daily work. The purpose of this thesis is to investigate and contribute with insights of how librarians perceive and manage different forms of disorder in public l

This thesis examines how political and corporate actors discursively framed the risks associated with deepwater drilling, following the Deepwater Horizon oil spill 2010. Despite the scale and severity of the disaster, the deepwater oil production in the Mexican Gulf has increased since 2010. Through a Critical Discourse Analysis, using Corpus Linguistics tools, the US Government and BP’s public pr

Infrastructures for family support is a subject that has been widely discussed in Sweden, both within healthcare and politics. However, it is not a concept that is often explored within the field of information studies, despite the many practical manifestations of such support that exist in public libraries today. This essay employs qualitative methods in the exploration of family supporting infra

Mer än 150 miljoner ton plast. Detta är den mängd som just nu befinner sig i våra hav, och denna siffra stiger varje dag. Detta har destruktiva konsekvenser för de djur som lever där. Djuren fastnar i plasten och kan skadas både in- och utvändigt. Men plasten är lömskare än så. För att i plasten gömmer sig kemikalier som kallas för bisfenoler. Denna studie utvärderar vilka konsekvenser dessa har pThis study systematically reviews the endocrine-disrupting effects of Bisphenol A (BPA) and Bisphenol S (BPS) on aquatic vertebrates and invertebrates to assess potential health- and ecological risks. Scientific articles were analyzed to compare the impacts of these chemicals on reproductive systems, oxidative stress, neurotoxicity, and metabolism. Results indicate that BPA, even at low concentrat

This masters thesis handles segmentation of blood vessels in Wistor-rat lungs, scanned by a µm-CT scanner. These scans are very detailed 3D-volumes and have been rescaled to a more manageable size of 1024 × 1024 × 1024 voxels per volume. The main goals of the thesis is to find a more efficient way to perform segmentation in medical images and thus semi-supervised segmentation techniques have been

The rise of deepfake pornography in South Korea reflects a serious breakdown in the protection of human rights in digital spaces. In a society where technological development significantly shapes national identity, the rights to bodily autonomy, education, and freedom from inhumane treatment are increasingly compromised by systems that normalize gender-based violence. Deepfake abuse in South Korea

Coloured sticky traps are commonly used to monitor insect pests. Colour affects trap performance, with preferred colours often differing between species, making selection of trap colour for effective management of multiple pests challenging. Greenhouse whitefly (GWF) Trialeurodes vaporariorum and Western flower thrips (WFT) Frankliniella occidentalis, are major horticultural pests that often co-oc

Background and purpose: The CardioSwitch-study demonstrated that patients with solid tumors who develop cardiotoxicity on capecitabine or 5-fluorouracil (5-FU) treatment can be safely switched to S-1, an alternative fluoropyrimidine (FP). In light of the European Medicines Agency approval of S-1 in metastatic colorectal cancer (mCRC), this analysis provides more detailed safety and efficacy inform

Amyloid fibrillering, en process där peptider (små protein) klumpas ihop, är idag associerat med en rad sjukdomar såsom Alzheimers sjukdom och diabetes typ 2. En peptid som är associerad med diabetes typ 2 är IAPP. Peptiden har hittats fibrillerad i bukspottskörteln i många patienter med diabetes typ 2. I tidigare studier har det hittats en koppling mellan små plaster, så kallade nanoplaster, och The impact of nanoparticles on amyloid fibrillation has been studied for some time due to the amount of nanoparticles that can be found in nature due to human release. Previous studies have shown that different nanoparticles may affect the length of the lag phase of the fibrillation process. This has been studied on peptides such as amyloid beta and islet amyloid polypeptide. Research has shown th