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CONTEXT: Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population.OBJECTIVE: To generate large-scale evidence on whether 2 common variants of LRP5 (Val667Met, Ala1330Val) and 1 variant of LRP6 (Ile1062Val) are associated w
Technical infrastructures of the society are becoming more and more interconnected and interdependent, i.e. the function of an infrastructure influences the function of other infrastructures. Disturbances in one infrastructure therefore often traverse to other dependent infrastructures and possibly even back to the infrastructure where the failure originated. It is becoming increasingly important
The Schrodinger operator on the half-line with periodic background potential perturbed by a certain potential of Wigner-von Neumann type is considered. The asymptotics of generalized eigenvectors for lambda is an element of C+ and on the absolutely continuous spectrum is established. The Weyl-Titchmarsh-type formula for this operator is proven.
OBJECTIVE: Screening of hypertension has been advocated for early detection and treatment. Severe hypertension (grade 3 hypertension) is a strong predictor for cardiovascular disease. This study aimed to evaluate not only the risk factors for developing severe hypertension, but also the prospective morbidity and mortality risk associated with severe hypertension in a population-based screening and
The influence of age and sex steroids on bone density and geometry of the radius was examined in two European Caucasian populations. Age-related change in bone density and geometry was observed. In older men, bioavailable oestradiol may play a role in the maintenance of cortical and trabecular bone mineral density (BMD). To examine the effect of age and sex steroids on bone density and geometry of
In Part I of this study [1], good agreement between experimental measurements and results from Monte Carlo simulations were obtained for the spatial intensity distribution of a laser beam propagating within a turbid environment. In this second part, the validated Monte Carlo model is used to investigate spatial and temporal effects from distinct scattering orders on image formation. The contributi
The plasma proteome is highly dynamic and variable, composed of proteins derived from surrounding tissues and cells. To investigate the complex processes that control the composition of the plasma proteome, we developed a mass spectrometry-based proteomics strategy to infer the origin of proteins detected in murine plasma. The strategy relies on the construction of a comprehensive protein tissue a
Popular Abstract in Swedish Vårt immunsystem består av ett nätverk av olika sorters celler och molekyler, vars uppgift är att försvara oss mot patogener (sjukdomsalstrande organismer) som till exempel virus och bakterier, medan det samtidigt måste tolerera proteiner och ämnen som finns naturligt i vår kropp. Immunsystemet kan delas upp i två delar; det medfödda (eller ospecifika) och det adaptiva Mucosal tissues such as the intestine present an enormous surface area to the outside environment and are continually exposed to foreign antigens in food and microflora. Thus, the intestinal mucosa must must remain tolerant to these innocuous antigens while at same time be able to mount effective immune responses to pathogens. Intestinal dendritic cells (DCs) and macrophages, found throughout the
Mixtures of powders of platinum with nickel or cobalt to obtain Ni0.75Pt0.25 or Co0.75Pt0.25 were mechanical alloyed by high energy ball milling. The results of crystal structure, morphology and electrocatalytic performance are presented for mechanically activated powders after 3 and 9 h of ball milling. Total solid solutions of Ni and Co with platinum were analyzed by X-ray diffraction after 3 h
The etiology of abdominal aortic aneurysm (AAA) includes inflammation and endothelial dysfunction. To evaluate relations between these mechanisms and AAA growth, endothelin (ET)-1, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and CD40 ligand were related to yearly AAA growth for 2.9 +/- 1.6 years (mean +/- SD) in 178 patients with conservatively followed AAA. Total number of follow-up ye
Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet- undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million SNPs, and followed up the strongest findings in 410,000 subjects. Ten newly identified and two previously reported loci were strongly associated with variation i
Purpose: To clarify patient opinions about alcohol intervention in relation to surgery before investigating the effect in a Scandinavian multi-centre randomized trial. Material and Methods: A qualitative study. Thirteen consecutive alcohol patients with fractures participated after informed consent. They were interviewed during their hospital stay. The number of participants was based on the crit
There is currently a strongly growing interest in obtaining optimal control solutions for vehicle manoeuvres, both in order to understand optimal vehicle behaviour and, perhaps more importantly, to devise improved safety systems, either by direct deployment of the solutions or by including mimicked driving techniques of professional drivers. However, it is non-trivial to find the right combination
A review is given of how the production by plants of compounds useful as medicines or raw materials for manufacture of medicines is influenced by ultraviolet radiation, particularly by UV-B radiation (280-315 nm wavelength). The compounds considered in this review are flavonoids and other phenolics, alkaloids (especially indole terpenoid and purine alkaloids), essential oils and other terpenoids,
In this study, we respond to calls for further investigation on why and how scientists choose to commercialize their research. Mowery (University entrepreneurship and technology transfer: process design, and intellectual property, Elsevier, Oxford 2005), in his criticism of the US-system, emphasizes the need for multiple channels between university and industry. His argument makes the case of Swed
This paper deals with the implementation of model selection criteria to data generated by ARMA processes. The recently introduced modified divergence information criterion is used and compared with traditional selection criteria like the Akaike information criterion (AIC) and the Schwarz information criterion (SIC). The appropriateness of the selected model is tested for one- and five-step ahead p
Objective . Hypoglycaemia is regularly accompanied by hypovolaemia. To suggest a mechanism for this phenomenon, we reviewed data from eight studies conducted by our group and examined the circumstances under which rebound hypoglycaemia develops after intravenous infusion of glucose solutions. Material and methods. Forty healthy volunteers and 40 patients received a total of 122 infusions of glucos
