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Preen oil chemical composition encodes individuality, seasonal variation and kinship in black kites Milvus migrans

Evidence that bird odour can encode social information that can be used in chemical communication is growing, but is restricted to a few taxonomic groups. Among birds, diurnal raptors (i.e. birds from the Accipitriformes and Falconiformes order) have always been considered as mainly relying on their visual abilities. Although they seem to have a functional sense of smell, whether their odour can c

Mechanosensation : A Catch Bond That Only Hooks One Way

Single-molecule force spectroscopy and modeling have revealed that the adhesion molecule vinculin and F-actin form a catch bond that is dependent on the direction of forces along the actin filament. This may underlie the mechanisms by which cells sense directional physical cues.

The FAK-Arp2/3 interaction promotes leading edge advance and haptosensing by coupling nascent adhesions to lamellipodia actin

Cell migration is initiated in response to biochemical or physical cues in the environment that promote actin-mediated lamellipodial protrusion followed by the formation of nascent integrin adhesions (NAs) within the protrusion to drive leading edge advance. Although FAK is known to be required for cell migration through effects on focal adhesions, its role in NA formation and lamellipodial dynami

Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines

Cancer cells are defined by their ability to invade through the basement membrane, a critical step during metastasis. While increased secretion of proteases, which facilitates degradation of the basement membrane, and alterations in the cytoskeletal architecture of cancer cells have been previously studied, the contribution of the mechanical properties of cells in invasion is unclear. Here, we app

The XMM-SERVS survey : New XMM-Newton point-source catalogue for the XMM-LSS field

We present an X-ray point-source catalogue from the XMM-Large Scale Structure (XMMLSS) survey region, one of the XMM-Spitzer Extragalactic Representative Volume Survey (XMM-SERVS) fields. We target the XMM-LSS region with 1.3 Ms of new XMM-Newton AO-15 observations, transforming the archival X-ray coverage in this region into a 5.3 deg2 contiguous field with uniform X-ray coverage totaling 2.7 Ms

Severe diphtheria with neurologic and myocardial involvement in a Swedish patient : A case report

Background: Diphtheria is caused by Corynebacterium diphtheriae. Although waning in incidence diphtheria can cause severe disease as in this rare Swedish case with several complications. Case presentation: A 55-year old male presented to the emergency room with severe respiratory symptoms and greyish membranes in the airways, which turned positive for C. diphtheriae. He was put on ventilator suppo

A Quality Scorecard for the era of Industry 4.0

A Quality Scorecard (QSC) performance measurement model is proposed to evaluate the quality aspects of an organization in Industry 4.0. To design a QSC for the ‘Fourth Industrial Revolution’, we examined existing measures regarding costs of quality items. The measurement system was refined by simplifying duplicate measures and incorporating quality elements considered in recent international stand

Cost assessment of a production system–A method targeting a product´ s aggregated value stream costs

A production system is often complex, involving several production steps with a material flow entering and exiting at different stages throughout the value stream. This article aims to present a method giving the aggregated cost of a product in a production system, were material and components entering the value stream carrying their own capital and handling costs. The article describes an empiric

Assessing imprecision in Cochrane systematic reviews : A comparison of GRADE and Trial Sequential Analysis

Background: The evaluation of imprecision is a key dimension of the grading of the confidence in the estimate. Grading of Recommendations Assessment, Development and Evaluation (GRADE) gives recommendations on how to downgrade evidence for imprecision, but authors vary in their use. Trial Sequential Analysis (TSA) has been advocated for a more reliable assessment of imprecision. We aimed to evalua

Socioeconomic differences in smoking cessation : The role of social participation

Objectives: The aim of this study was to investigate whether psychosocial resources explain socioeconomic differences in smoking cessation and its maintenance. Methods: A subpopulation of 11,837 individuals from the Malmö Diet and Cancer Study interviewed in 1992-94, age range 45-64 years, was investigated in this cross-sectional study. A multivariate logistic regression model was used to assess r

Induction and knowledge-what

Within analytic philosophy, induction has been seen as a problem concerning inferences that have been analysed as relations between sentences. In this article, we argue that induction does not primarily concern relations between sentences, but between properties and categories. We outline a new approach to induction that is based on two theses. The first thesis is epistemological. We submit that t