Filtyp
Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other cancer types, germline and/or somatic mutations in BRCA1 and/or BRCA2 (BRCA1/BRCA2) also confer selective sensitivity to PARP inhibitors. Thus, assays to detect BRCA1/BRCA2-deficient tumors have been sought. Recently,
In general, melanoma can be considered as a UV-driven disease with an aggressive metastatic course and high mutational load, with only few tumors (acral, mucosal, and uveal melanomas) not induced by sunlight and possessing a lower mutational load. The most commonly activated pathway in melanoma is the mitogen-activated protein kinase (MAPK) pathway. However, the prognostic significance of mutation
With regard to Scandinavian cinema and television, the last decades have been marked by the unexpected international appeal and unforeseen longevity of Scandinavian crime or Nordic noir as it is sometimes labeled. This development has paved the way for ever increasing financial and artistic collaboration within the audiovisual industries, especially among the Scandinavian countries. But it has als
Handledsbrott är den vanligaste frakturen på en akutmottagning. De yngre vuxna patienterna är jämnt fördelade mellan könen men de äldre har en övervikt av kvinnor. Hos de äldre men även i medelåldern uppstår frakturen företrädesvis i ett skelett med olika grad av benskörhet. Frakturen behandlas oftast med gips utan operation men drygt en femtedel opereras. Om felställningen är stor eller om fraktu
