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Characterization of the glomerular filtration barrier is of fundamental importance for understanding the pathophysiology of proteinuric kidney diseases. Furthermore, it can be of key value in the understanding of microalbuminuria, which is often associated with endothelial dysfunction in conjunction with cardiovascular disease. In the four studies of this doctoral thesis, macromolecular probes hav

Background: Treatment of pediatric T-cell acute lymphoblastic leukemia (T-ALL) has improved, but there is a considerable fraction of patients experiencing a poor outcome. There is a need for better prognostic markers and aberrant DNA methylation is a candidate in other malignancies, but its potential prognostic significance in T-ALL is hitherto undecided. Design and Methods: Genome wide promoter D

The main theme of this review is the many-body physics of vortices in quantum droplets of bosons or fermions in the limit of small particle numbers. Systems of interest include cold atoms in traps as well as electrons confined in quantum dots. When set to rotate, these in principle different quantum systems show remarkable analogies. The topics reviewed include the structure of the finite rotating

The yrast sequence of the neutron-rich dysprosium isotope Dy-168 has been studied using multinucleon transfer reactions following collisions between a 460-MeV Se-82 beam and an Er-170 target. The reaction products were identified using the PRISMA magnetic spectrometer and the gamma rays detected using the CLARA HPGe-detector array. The 2(+) and 4(+) members of the previously measured ground-state

Our understanding of metal-atom cluster adsorption on graphene on Ir(111) is based on elementary chemical ideas, rehybridization, and buckling, supported by density functional theory (DFT) calculations. We tested the DFT picture by comparing calculated core level spectra to x-ray photoemission spectroscopy (XPS) measurements. For pristine graphene, which forms a gently undulating moire on Ir(111),

Experiments performed in a lab are often considered generali- zable over both people and social settings. The problems with generalizing over different groups of people are well known, but it is only recently that changes in behavior depending on thesocial setting have been examined. Large changes in behavior can be seen in trivial cognitive tasks, depending on whether the participant is alone or

Popular Abstract in Swedish SAMMANFATTNING (SUMMARY IN SWEDISH) Jod är nödvändigt för utvecklingen och hälsan hos alla högre djur inklusive männi-ska, men det är ett relativt sällsynt grundämne. Man får i sig jod via kosten och det högsta jodinnehållet har fisk och skaldjur eftersom havssalt innehåller jod. Jod finns även i mejeriprodukter och i mindre mängder i grönsaker, men jodinnehållet i dessABSTRACT Background: Iodine is essential for development and growth as a constituent in thyroid hormones. Biological mechanisms for iodide uptake and concentration are very important, espe-cially as iodine is a relatively scarce element. Active iodide transport into thyroid fol-licular cells is mediated by the sodium/iodide symporter (NIS), powered by Na+/K+-ATPase. NIS is expressed also in extra

BACKGROUND/OBJECTIVES: Evidence from prospective studies is consistent in showing an inverse association between dietary fibre intake and risk of ischaemic heart disease (IHD), but whether dietary fibre from various food sources differ in their effect on IHD risk is less clear. The objective of this study was to assess the associations of total and food sources of dietary fibre with IHD mortality

The process of an ultrahigh vacuum annealing of a diamond-like carbon film deposited on a silicon substrate has been studied in situ using a photoemission microscope mounted at the MAX-lab synchrotron's radiation source. After the annealing the film was examined ex situ using an atomic force microscope. It is revealed that the graphitization of the film occurs and round formations of several micro

Popular Abstract in Swedish Studier har visat att inte bara individer med diabetes utan ocksa de som har forstadier till diabetes, namligen forhojt fasteblodsocker och nedsatt glukostolerans, loper en okad risk for att drabbas av saval hjartkarlsjukdom som hjartsvikt. Daremot har man sett att den okade risken forenad med diabetes verkar minska med aldern. Studier pa aldre individer ar dock sparsamThe risk of cardiovascular disease (CVD) and heart failure (HF) among individuals with diabetes is at least two times greater than in non-diabetic subjects. However, the excess risk of CVD in diabetic subjects seems to decrease with age. As the majority of patients with diabetes, CVD and HF are elderly it is important to establish the extent to which the associations between these conditions diffe

Background: The goal of clinical computed tomography (CT) is to produce images of diagnostic quality using the lowest possible radiation exposure. Degradation of image quality, with increased image noise and reduced spatial resolution, is a major limitation for radiation dose reduction in CT. This can be counteracted with new post-processing image filters and iterative reconstruction (IR) algorith

The life cycle cost (LCC) of the heating, cooling and ventilation system was simulated for a typical cell office building, multi-family dwelling and detached house. Different ventilations systems were simulated resulting in different heating and cooling system designs. A health-related cost dependent on the airflow rate which was based on recent studies was added to the LCC for the dwellings as we

Diabetes mellitus is one of the most common endocrine disorders in dogs and is commonly proposed to be of autoimmune origin. Although the clinical presentation of human type 1 diabetes (T1D) and canine diabetes are similar, the aetiologies may differ. The aim of this study was to investigate if autoimmune aetiology resembling human T1D is as prevalent in dogs as previously reported.

Little is known about risk/protective factors for sexually coercive behavior in general population youth. We used a Swedish school-based population survey of sexual attitudes and experiences (response rate 77%) and investigated literature-based variables across sexually coercive (SEX), non-sexual conduct problem (CP), and normal control (NC) participants to identify general and specific risk/prote

BACKGROUND: Orthostatic hypotension (OH) can be seen in as many as 30% to 50% of the elderly population as well as in dementia. OH is part of the autonomic dysfunction in dementia with Lewy bodies (DLB) and prevalent in the majority of these patients. It is also suggested to be a negative prognostic factor for survival in DLB. A detailed interpretation of the 10-minute orthostatic blood pressure m