Filtyp
The seminal vesicle secretions of guinea pig and rabbit were analyzed for semen coagulum proteins. Using SDS-PAGE we discovered a previously not fully recognized semen coagulum protein, Svp5, in the guinea pig and a single predominant component, SVP200, in the rabbit. Potential genes of these proteins were identified in genome databases by their homology with human and murine genes. The structure
Background: Glenohumeral osteoarthritis can, in the most severe cases, require surgery with insertion of a shoulder arthroplasty. A design with a stem in the humeral bone canal is currently regarded as the standard treatment option in patients who have an intact rotator cuff function, but complications related to the stem including humeral fractures can have devastating consequences. By using a st
Background: To date, targeted temperature management (TTM) is the only neuroprotective intervention after resuscitation from cardiac arrest that is recommended by guidelines. The evidence on the effects of TTM is unclear. Methods/design: The Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest (TTM2) trial is an international, multicentre, parallel group, investig
This book presents studies of ways in which people and organizations deal with the overflow of information, goods, or choices. The contributors explore two main themes. The first is the emergence of overflows: What is defined as overflow? Here the notion of framing as coined by Michel Callon has guided our approach. There is no overflow until some flow has been framed; framing means defining, and
För 300 år sedan avrättades en man och hans avlidna hustrus syster ifall det avslöjades att de hade haft sexuellt umgänge. Deras relation definierades som incestuös och benådningar var sällsynta. Incestförbuden omfattade då många fler relationskategorier än idag och fram till sent 1800-tal var de flesta incestuösa relationer frivilliga föreningar mellan två vuxna individer som saknade biologiska sThis study brings out the norms and culturally dependent values that formed the basis of the theoretical regulation and the practical handling of incest cases in Sweden 1680–1940, situating this development in a wider European context. It discusses a broad variety of general human subjects that are as important today as they were hundreds of years ago, such as love, death, family relations, religi
The liver possesses a remarkable regenerative capacity based partly on the ability of hepatocytes to re-enter the cell cycle and divide to replace damaged cells. This capability is substantially reduced upon chronic damage, but it is not clear if this is a cause or consequence of liver disease. Here, we investigate whether blocking hepatocyte division using two different mouse models affects physi
Satellite cell proliferation is an essential step in proper skeletal muscle development and muscle regeneration. However, the mechanisms regulating satellite cell proliferation are relatively unknown compared to the knowledge associated with the differentiation of satellite cells. Moreover, it is still unclear whether overload muscle fiber hypertrophy is dependent on satellite cell proliferation.
Left ventricular (LV) stroke work (SW) is calculated from the pressure-volume (PV) loop. PV loops do not contain information on longitudinal and radial pumping, leaving their contributions to SW unknown. A conceptual framework is proposed to derive the longitudinal and radial contributions to SW, using ventricular force-length loops reflecting longitudinal and radial pumping. The aim of this study
Ecological diversity among diurnal birds of prey, or raptors, is highlighted regarding their sensory abilities. While raptors are believed to forage primarily using sight, the sensory demands of scavengers and predators differ, as reflected in their visual systems. Here, I have reviewed the visual specialisations of predatory and scavenging diurnal raptors, focusing on (1) the anatomy of the eye a
Primary ship waves generated by conventional marine vessels were investigated in the Furusund fairway located in the Stockholm archipelago, Sweden. Continuous water level measurements at two locations in the fairway were analyzed. In total, 466 such events were extracted during two months of measurements. The collected data were used to evaluate 13 existing predictive equations for drawdown height
The datafication of journalism creates new demands on journalists. The set of skills and the daily work in the newsroom have changed the profession where traditional values might still be present but are challenged by how data is received, constructed and analyzed. This impacts how journalism is being produced; data contributes to the reporting and provides opportunities on how to conduct research
The structure and function of proteins are strongly affected by the surrounding solvent water, for example through hydrogen bonds and the hydrophobic effect. These interactions depend not only on the position, but also on the orientation, of the water molecules around the protein. Therefore, it is often vital to know the detailed orientations of the surrounding ordered water molecules. Such inform
BACKGROUND: Serial assessment of phosphorus is currently recommended by the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines, but its additional value versus a single measurement is uncertain. METHODS: We studied data from 17 414 HD patients in the Dialysis Outcomes and Practice Patterns Study, a prospective cohort study, and calculated the area under the curve (AUC) by multiplying the
The stacked multilevel (SML) klystron modulator topology has been suggested as an alternative to conventional pulse transformer-based topologies in an attempt to improve output pulse performance and reduce system size for long-pulse applications. In this topology, a power converter chain including a high-frequency transformer generates the output pulse in a pulse modulation/demodulation scheme, el
Lymphotoxin β-receptor (LTβR) signalling promotes lymphoid neogenesis and the development of tertiary lymphoid structures1,2, which are associated with severe chronic inflammatory diseases that span several organ systems3-6. How LTβR signalling drives chronic tissue damage particularly in the lung, the mechanism(s) that regulate this process, and whether LTβR blockade might be of therapeutic value
In order to make our production and consumption systems more sustainable, there is a need to further explore and support novel business models with higher sustainability potential. Use-oriented product-service systems (u-PSS) are considered a promising alternative to traditional ownership-based business models, as they may result in lower environmental impacts. The presence of u-PSS in consumer go
Evaluations hold the potential to support decision-making so that current global challenges related to climate and energy can be addressed; however, as the challenges are becoming increasingly large and complex, new and transformative evaluation approaches are called for. Such transformative evaluation in turn builds on an extended and more deliberate use of evaluations. This study focuses on the
