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I detta examensarbete studeras inverkan av pH på konformationsprocesserna i enzym FKBP12 med hjälp av kärnmagnetisk resonansspektroskopi (NMR). Tidigare studier har identifierat två konformationsprocesser i FKBP12, där den mindre befolkade konformationen i den snabbare processen misstänks vara en intermediär konformation mellan konformationerna som deltar i den långsammare processen. I projektet gThis master thesis project reports the dependence on pH of the conformational exchange in the enzyme FKBP12. Previous NMR studies have identified two conformational exchange processes in FKBP12, where the faster process is believed to be an exchange to an intermediate state between the more slowly exchanging conformations. In this project I carried out different NMR experiments across the pH-inte

Today’s rapidly changing environment amplifies the need for companies no matter the industry, to stay on top of their game and not lose market share to competing firms. This is particularly true of companies in mature industries, and therefore, is a worthy area of study and the focus of this thesis. Rethinking Competitive Strategy in Mature Industries is an in-depth, exploratory study, with an em

Software development for embedded systems has a lot of dependencies on the hardware of the system. To possibly reduce the lead time and ease the development process, an emulated model is investigated. This model is examined in terms of how it fits in the platform transition, daily development and testing processes at Axis. The results indicate that an emulated model is a powerful tool for a softwa

Geografiska data (platsbaserade data) är en självklar del av den information som når oss dagligen. Idag (2016) använder företag och organisationer geografiska data i många av sina informationsforum. Till exempel tillhandahåller webbsidor vanligen kartor för att visa på vilken plast ett företag är lokaliserat. En stor del av att jobba med geografiska data är att hitta och veta relationer mellan olSpatial relationships are a comprehensive and essential part of geographical information management and GIS. Topological relationships are a subgroup of the spatial relationships. They are defined by the fact that they do not break under topological transformations, meaning they remain when stretching, twisting or crumbling the underlying space. Topological relationships are for instance relations

Abstract Responsive web design is the technique lot of companies apply to their website today. The reason is, that with this technique the website’s content adapts nicely on all devices from mobile phones to desktops. IKEA recently followed this trend on some of their platforms and among these is their internal communication platform called IKEA Inside Outside. IKEA is not entirely satisfied in

Användningen av smarta telefoner och områden i vilka smarta telefonlösningar erbjuds, har ökat drastiskt det senaste decenniet. Det område som däremot inte har varit lika benäget att anta detta tillvägagångssätt är restaurangbranschen. Målet med denna studie syftar till att undersöka hur villiga användare är att anpassa sig till detta tillvägagångssätt och beskriver de krav och önskemål av en sådaThe use of smart phones and the areas in which smart phone solutions are provided have increased immensely over the past decade. However, one area which has not been as keen of adopting the smart phone approach is the restaurant area. This study aims to investigate the amenability of users to adapt to this approach and outlines the requirements and desires of such a product. It also presents a sol

In this thesis, two methods were developed for a web-based GIS to make the spatial perspective of flood disaster risk reduction and response accessible. Flood disaster can cause major disruption to the street network, which further affects the emergency services and evacuation work in finding the safest and fastest routes. Thus, a method for dynamic street network analysis was developed and implem

The present thesis explores the elements that affect the relationship between importers and exporters of agricultural products, using as case study the market for tropical fruits in Sweden. For this, the thesis looks into secondary data, backed with some interviews, to i) identify some of the perceptions and expectations that importers of tropical fruit have, ii) the way these affect the possibili

The purpose of this thesis was to reduce the start-up and restart time of a hemodialysis machine by targeting time consuming control loops. This was done by investigating different techniques of modelling to find the best combination of versatility and conformity to the process. Finding the best controller was done by evaluating different controllers in simulations with the model in MATLAB/Simulin

The aim of this study was to examine attitudes surrounding the needle exchange program in Malmö and Lund in Sweden. More specifically the aim was to examine how the staff of the needle exchange program experience the attitudes surrounding the needle exchange program and if/how these attitudes affect them in their work. The analysis of nine interviews with staff members revealed similarities in how

In June the 23, 2016 United Kingdom will hold a referendum on their EU-membership. One of the triggers was the letter that David Cameron sent to Donald Tusk November 10, 2015: “A settlement for the United Kingdom in a reformed Union“. The purpose of the present thesis is to make a profound analysis of David Cameron’s letter, analyzing the proposals and demands he places on EU. Cameron has four ma

This report is made in order to evaluate the fire safety for the personnel and patients at Ystad hospital. A risk analysis was conducted, focusing on hazards related to fire, and on the client's wishes it was determined that the analysis should be done on the section of the hospital called building 17 and that the writers especially should consider the risk of arson. Through the analysis two d

This report is evaluating the evacuation safety of a sports hall in Borås, Boråshallen. It is a 6 floor building containing a basket hall and auxiliary training facilities. Fire scenarios of varying severity were evaluated. Computer modelling was done in a CFD software, FDS, to find the time to critical conditions. That in turn was compared to egress time calculated by evacuation simulation progra

Confronting Chinese E-commerce has increased rapidly in the past decade as well as its potential growing rate in the future, International E-commerce companies have realized the necessities of localization to attract more Chinese online consumers. However, many of them seem to have a hard time to compete with the local sites. This study aims to investigate design elements that are attracting the C

This Master’s thesis describes a method for real-time estimation of a vehicle’s mass for automobiles using recursive least squares. The method has its foundation in the longitudinal dynamics of the vehicle and is designed to be easy to adapt to different vehicle models. The mass estimation rely on a underlying road grade estimation and driveline efficiency estimation for every gear. The road grade

Sveriges plansystem är omfattande och processerna tar ofta lång tid. För att kunna möta akuta behov av bostäder och främja en effektiv samhällsutveckling behövs vissa ventiler i systemet. Tidsbegränsade bygglov tillåter avsteg från vissa förutsättningar som normalt behöver uppfyllas för permanenta bygglov. Syftet med arbetet är att utreda hur regeln om tidsbegränsade bygglov i 9 kap 33 § PBL tolThere is a big need for new residential areas in Sweden but the process of exploitation and building is time-consuming. Temporary Building Permits allow construction, even though some of the normally required criteria are not fulfilled. An ease in the legislation is useful in order to meet urgent needs and to achieve an efficient land use. The purpose of this thesis is to study how the regulatio

In recent year, many countries have achieved the economic growth to different extent all over the world, but more problems were emerged along with the process of development. The problem of income distribution has been raised and became a chronic concern for researchers and governments ever since. Not only the developing countries, but also the developed countries are suffering the inequality issu

Geographic Information Systems (GIS) have acquired greater relevance as tools to support decision-making processes, and during the last decades they have been used in conjunction with Multi-Criteria Decision Analysis techniques (GIS-MCDA) to solve real-world spatial problems. GIS-MCDA can be generally divided in Multi-Attribute and Multi-Objective techniques. Until now most of the applications of

This study investigated whether anchored prices induced biased choices and time estimations for the pursuit of an equal discount and if different degrees of social distance influenced these biases. A new measurement for quantifying the relative degree of bias was also proposed. A sample group of 142 students were tested from a university in southern Sweden. In a repeated measure design, each parti