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The immune system is integral to cardiovascular health and disease. Targeting inflammation ameliorates adverse cardiovascular outcomes. Atherosclerosis, a major underlying cause of cardiovascular disease, is conceptualized as lipid-driven inflammation in which macrophages play a nonredundant role. However, evidence emerging so far from single-cell atlases suggests a dichotomy between lipid-associa

Alzheimer’s disease (AD) is the most common neurodegenerative disease. Most cases of AD are considered idiopathic and likely due to a combination of genetic, environmental, and lifestyle-related risk factors. Despite occurring decades before the typical age of an AD diagnosis, early-life stress (ELS) has been suggested to have long-lasting effects that may contribute to AD risk and pathogenesis. S

BACKGROUND: The EAT-Lancet Commission proposed a global reference diet with both human health benefits and environmental sustainability in 2019. However, evidence regarding the association of such a diet with the risk of atrial fibrillation (AF) is lacking. In addition, whether the genetic risk of AF can modify the effect of diet on AF remains unclear. This study aimed to assess the association of

I mötet med människor som avviker från normen sker något viktigt med oss. Det ärmycket tack vare »den Andre« de som inte är som vi som vi får reda på vilka vi egentligen är.I västerlandet har kristendomen varit norm i tusen år, och det var under kristendomenstidiga historia som många av vår kulturs traditionella fiendebilder föddes. De har spelat en viktig roll för framväxten av vårt moderna samhä

While most greenhouse gases are not toxic and no pollutants, their increasing concentration in the atmosphere is enhancing the greenhouse effect and causing climate change. Climate change however is a massive threat to all global life-sustaining systems, and it will among other highly damaging consequences probably also create significant health problems. This chapter first explains the natural sc

Cognitive screening has been proposed for older adults diagnosed with chronic obstructive pulmonary disease (COPD). Therefore, we examined the change over time in cognitive function and the risk of incident dementia in older adults after COPD diagnosis. A sample of 3,982 participants from the population-based cohort study Good Aging in Skåne was followed for 19 years, and 317 incident COPD cases w

Glyptothorax vatandousti, new species, from the upper Karkheh drainage, a tributary of the Iranian Tigris, is distinguished from its congeners in the Persian Gulf basin by having the flank with a fine, pale-brown mottled pattern overlaid by small and large, blackish or dark-brown blotches, deep caudal-peduncle (its depth 1.1–1.3 times in length), and without, or with a pale-brown triangle-shaped b

ObjectiveTo determine the feasibility of a digitally automated population-based programme for organised prostate cancer testing (OPT) in Southern Sweden.Patients and MethodsA pilot project for a regional OPT was conducted between September 2020 and February 2021, inviting 999 randomly selected men aged 50, 56, or 62 years (y). Risk stratification was based on PSA, PSA density (PSAD), and biparamet

When the coronavirus spread globally in early 2020, many governments issued national lock downs of schools, institutions, and businesses. As the epidemic turned into a pandemic, the health crisis also became a societal crisis, and many universities and research foundations issued COVID-19 grants to study the societal implications of the crisis. In this article, we discuss sociological research dur

The article examines how dwellers in Kenya’s informal settlements engage in continuous tinkering of a particular grassroots infrastructure: local currencies. The article argues that the malleability of these grassroots infrastructures enables grassroots networks to actively and creatively engage in reclaiming and reorganizing money, a critical infrastructure. The argument is built in three steps.

Circular economy (CE) has gained attention in the real estate and construction policy, practice, and research in the past few years. This study explores how two neighboring Nordic countries and EU member states, Sweden and Finland, are transitioning toward circularity in the real estate and construction industry context. The aim is reached through a review of CE policies on the national and indust

ObjectivesTo develop an in-house matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) library for improved identification of species and subspecies of the Streptococcus bovis/Streptococcus equinus-complex (SBSEC).Methods236 SBSEC isolates from blood stream infections and culture collections, determined by whole genome sequencing to subspecies level, were grow

Bacterial extracellular vesicles (EVs) contain numerous active substances that mediate bacterial interactions with their host and with other microbes. Best defined are the EVs from Gram-negative bacteria that have been shown to deliver virulence factors, modulate the immune responses, mediate antibiotic resistance, and also inhibit competitive microbes. Due to the complex cell wall structures of G

Accurate visualization and understanding of liquid breakups and dynamics of liquid jets, sheets, blobs and ligaments is important for a wide range of spray applications. Here, temporally resolved 3D measurements are necessary to obtain the complete characterization these processes. The currently available 3D imaging techniques are usually based on time-averaged data and do not have the capability

Droplets generated by talking and coughing play a major role in the spreading of COVID-19. Thus, there is a need for accurate measurements of the physical properties of exhaled droplets just at the exit of the mouth, including their number and velocity. Several challenges are associated with imaging coughed droplets. First, large variation of droplet size will translate to a large range of signal

Background & Aims: Earlier studies have provided varying risk estimates for lymphoma in patients with inflammatory bowel disease (IBD), but often have been limited by detection biases (especially during the first year of follow-up evaluation), misclassification, and small sample size; and rarely reflect modern-day management of IBD. Methods: We performed a binational register-based cohort stud

Analysis of structures subjected to moving loads is presented. In particular, structural effects due to structure-vehicle interaction are studied. The basic equations of the structure-vehicle system are derived by means of continuum mechanics, the finite element method and multibody dynamics.In order to consider the interaction between structure and vehicle in a straightforward way, a special stru

A constitutive model for concrete is formulated. Tensile fracture is described using a smeared crack approach where the fracrure energy is considered and the shear stiffneess in the cracked region is gradually reduced as crackling develops. Environmentally induced strain due to variation of moisture and temperature is taken into account and may be made dependent on the stress state. Creep is model

We report on the physical-point RBC/UKQCD calculation of the leading isospin-breaking corrections to light-meson leptonic decays. This is highly relevant for future precision tests in the flavour physics sector, in particular the first-row unitarity of the Cabibbo-Kobayashi-Maskawa matrix containing the elements Vus and Vud. The simulations were performed using Domain-Wall fermions for 2 + 1 flavo