Objectives: This study aims to determine the independent impact of definitions of remission/low disease activity (LDA) on direct/indirect costs (DCs, ICs) in a multicentre inception cohort. Methods: Patients from 31 centres in 10 countries were enrolled within 15 months of diagnosis and assessed annually. Five mutually exclusive disease activity states (DAS) were defined as (1) remission off-treat

The Scania and Blekinge Court of Appeal in southern Sweden was established by King Charles XIV John in 1821. The iconography used during its period in Kristianstad, until it moved to Malmö in 1917, provides an excellent example of ‘power in images’, highlighting the transition from neoclassicism to national romanticism and finally modernity.In the text, I discuss the choices of symbols that were m

Lund University (Sweden) teacher education students' reflections constitute the foundation for this chapter. The students wrote about their situation, what they could learn from it and how they could bring these lessons into their future roles. The students' voices on digitalisation and isolation in their learning experiences illustrate the importance of belonging and motivation in education. The

We present here the genomic structures for two genes implicated in craniofacial development. Retinoic acid receptor alpha (RARA), or a gene in its vicinity, has been implicated in non-syndromic cleft lip and palate, based on both association and linkage studies. Using primers directed to the 3' -UTR of the published cDNA sequence, we screened a human genomic BAC library to obtain a clone containin

BACKGROUND: Respiratory syncytial virus (RSV) and influenza cause significant health challenges, particularly for individuals with comorbid conditions and older adults. However, information on the clinical manifestations and outcomes of adults hospitalized with RSV in Europe remains limited.METHODS: This multicenter observational cohort study of adults hospitalized with RSV or influenza A or B fro

Complex metabolic diseases due to overnutrition such as obesity, type 2 diabetes, and fatty liver disease are a major burden on the healthcare system worldwide. Current research primarily focuses on disease endpoints and trying to understand underlying mechanisms at relatively late stages of the diseases, when irreversible damage is already done. However, complex interactions between physiological

BACKGROUND: Self-reported mental stress is not consistently recognized as a risk factor for stroke. This prompted development of a novel algorithm for stress-phenotype indices to quantify chronic stress prevalence in relation to a modified stroke risk score in a South African cohort. The algorithm is based on biomarkers adrenocorticotrophic hormone, high-density lipoprotein cholesterol, high-sensi

While hybridisation in vascular plants has received considerable attention, hybridisation in bryophytes is still relatively understudied. Here we investigate hybridisation between two species from the moss genus Dicranum Hedw. Dicranum scoparium Hedw. and D. bonjeanii De Not. are two moss species of the D. scoparium species complex with partially overlapping morphology and habitat ranges. This stu

Objectives Patients with type 2 diabetes mellitus (DM) run lower risk for abdominal aortic aneurysm (AAA, aortic diameter ≥ 30 mm) and its complications. We aimed to evaluate associations between disturbances in glucose metabolism and arterial stiffness, AAA, and abdominal aortic diameter in 65-year-old men. Methods Forty-eight 65-year-old men with screening-detected AAA and 115 men with normal ab

Satu Lähteenoja’s PhD thesis consists of five published articles and an extensive introduction. The articles make strong, or even major, contributions to research and Satu Lähteenoja’s contribution to the articles is clearly demonstrated. The introduction combines the articles into a whole and through the introduction the contribution is clearly bigger than the sum of the five articles.

Background: Transcatheter aortic valve implantation (TAVI) has shown similar or improved clinical outcomes compared with surgical aortic valve replacement (SAVR) in patients with symptomatic severe aortic stenosis at low risk for surgical mortality. This cost-utility analysis compared TAVI with SAPIEN 3 versus SAVR in symptomatic severe aortic stenosis patients at low risk of surgical mortality fr

Airborne particle emissions from road vehicles represent a significant concern for urban air quality. Among the key contributors to non-exhaust emissions (NEE) are vehicle disc brakes, which have recently been recognized as equally important as exhaust emissions. In disc brake systems, the brake pads are pressed against the rotating disc to decelerate the vehicle. This contact causes wear on the d

Det svenska statsskicket omfattar en företeelse som brukar beskrivas som mer eller mindre unikt i världen: idén om att statliga förvaltningsmyndigheter ska vara självständiga i förhållande till regeringen. Mer precist brukar jurister tala om en självständighetsprincip som hänger ihop med vad som kallas ett förbud mot ministerstyre. Denna självständighetsprincip är uttryckligen reglerad i grundlag.

Workplace incivility is a pervasive issue with implications for employee well-being. Drawing upon Self-Determination Theory, this study explores the association between experienced workplace incivility, need satisfaction, and work motivation and investigates whether workplace incivility is negatively associated with autonomous work motivation. We hypothesize that experiencing workplace incivility Workplace incivility is a pervasive issue with implications for employee well-being. Drawing upon Self-Determination Theory, this study explores the association between experienced workplace incivility, need satisfaction, and work motivation and investigates whether workplace incivility is negatively associated with autonomous work motivation. We hypothesize that experiencing workplace incivility

Given the negative consequences of bullying, it is important to identify teacherapproaches and to what degree students trust that their teachers can manage the class. Thus, this experimental study examined whether students’ trust in their teacher’s ability to manage the class would be positively associated with defending victims and negatively associated with pro-bullying and passive bystanding. 2

Flow diverter devices are small stents used to divert blood flow away from aneurysms in the brain, stagnating flow and inducing intra-aneurysmal thrombosis which in time will prevent aneurysm rupture. Current devices are formed from thin (∼25 μm) wires which will remain in place long after the aneurysm has been mitigated. As their continued presence could lead to secondary complications, an absorb