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Background: The tumor microenvironment in pancreatic cancer has a multifaceted role in disease development and progression. Prolyl 4-hydroxylase subunit alpha 2 (P4HA2) and proteinase 3 (PRTN3) are involved in the synthesis and degradation of collagen in the tumor microenvironment and have been identified as prognostic biomarker candidates for pancreatic cancer in our previous mass spectro-metric
The PHENIX collaboration has measured high-pT dihadron correlations in p+p, p+Al, and p+Au collisions at sNN=200 GeV. The correlations arise from inter- and intrajet correlations and thus have sensitivity to nonperturbative effects in both the initial and final states. The distributions of pout, the transverse-momentum component of the associated hadron perpendicular to the trigger hadron, are sen
A large literature documents how intergenerational mobility—the degree to which (dis)advantage is passed on from parents to children—varies across and within countries. Less is known about the origin or persistence of such differences. We show that US areas populated by descendants to European immigrants have similar levels of income equality and mobility as the countries their forebears came from
AIMS: Pretreatment of patients with ST-elevation myocardial infarction (STEMI) with P2Y12 receptor antagonists is supported by guidelines and is a common practice despite the lack of definite evidence for its benefit. METHODS AND RESULTS: Using data from the Swedish Coronary Angiography and Angioplasty Registry on procedures between 2005 and 2016, we stratified all patients who underwent primary p
Using the pentadentate ligand (N-bis(1-methyl-2-benzimidazolyl)methyl-N-(bis-2-pyridylmethyl)amine, 2pyN2B), presenting two pyridyl and two (N-methyl)benzimidazolyl donor moieties in addition to a central tertiary amine, new Mn II and Mn IV -oxo complexes were generated and characterized. The [Mn IV (O)(2pyN2B)] 2+ complex showed spectroscopic signatures (i.e., electronic absorption band maxi
A numerical model for simulating beach-dune evolution at decadal to centennial time scales is developed. The work builds on an existing semi-empirical cross-shore model, the CS-model, to which the effect of sea level rise is added and the routines for aeolian transport and morphological dune evolution are improved. The model development is based on established conceptual models from the literature
Migraine is a common, severe disease, affecting the brain and blood vessels, causing much pain, time missed from work and family, and severe disability. It affects approximately 12% of most Western populations studied and affects women three times more than men. Cluster headache is a much less common dysfunction of the hypothalamus, involving the sphenopalatine ganglion and other areas; it causes
Objective: To evaluate the Patient Participation in Rehabilitation Questionnaire (PPRQ) according to Rasch measurement theory. Method: Five hundred twenty-two post-discharge patients from a neurological rehabilitation unit were included. The PPRQ questionnaire comprises 20 items rated by a cohort of 522 patients about their experiences of participating in rehabilitation. The measurement properties
Non-typeable Haemophilus influenzae (NTHi) and encapsulated Haemophilus influenzae type b (Hib) were inoculated into the middle ears of Sprague- Dawley rats. Tympanic membrane (TM) status was assessed otomicroscopically and specimens from various middle ear areas were prepared for light microscopy at various times during the acute phase and up to 6 months after inoculation. Irrespective of bacteri
Studies of infection by Phytophthora infestans—the causal agent of potato late blight—in wild species can provide novel insights into plant defense responses, and indicate how wild plants might be influenced by recurrent epidemics in agricultural fields. In the present study, our aim was to investigate if different clones of Solanum dulcamara (a relative of potato) collected in the wild differ in
The solar neighbourhood contains disc stars that have recently crossed spiral arms in the Galaxy. We propose that boundaries in local velocity distributions separate stars that have recently crossed and been more strongly perturbed by a particular arm from those that haven't. Ridges in the stellar velocity distributions constructed from the second Gaia data release trace orbits that could have tou
The gravitational interaction between two objects on similar orbits can effect noticeable changes in the orbital evolution even if the ratio of their masses to that of the central body is vanishingly small. Christou (Icarus 174:215–229, 2005) observed an occasional resonant lock in the differential node ΔΩ between two members in the Himalia irregular satellite group of Jupiter in the N-body simula
In extending the analysis of the four secular resonances between close orbits in Li and Christou (Celest Mech Dyn Astron 125:133–160, 2016) (Paper I), we generalise the semianalytical model so that it applies to both prograde and retrograde orbits with a one-to-one map between the resonances in the two regimes. We propose the general form of the critical angle to be a linear combination of apsidal
We explore the connections between stellar age, chemistry, and kinematics across a Galactocentric distance of 7.5 < R(kpc) < 9.0, using a sample of ~12 000 intermediate-mass (FGK) turn-offstars observed with the RAdial Velocity Experiment (RAVE) survey. The kinematics of this sample are determined using radial velocity measurements from RAVE, and parallax and proper motion measurements from the T
