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Exome sequencing of contralateral breast cancer identifies metastatic disease
Women with contralateral breast cancer (CBC) have significantly worse prognosis compared to women with unilateral cancer. A possible explanation of the poor prognosis of patients with CBC is that in a subset of patients, the second cancer is not a new primary tumor but a metastasis of the first cancer that has potentially obtained aggressive characteristics through selection of treatment. Exome an
Microbial change in warming soils
Higher education is associated with a better rheumatoid arthritis outcome concerning for pain and function but not disease activity : results from the EIRA cohort and Swedish rheumatology register
INTRODUCTION: Whether low socioeconomic status (SES) is associated with worse rheumatoid arthritis (RA) outcomes in countries with general tax-financed healthcare systems (such as Sweden) remains to be elucidated. Our aim was to investigate the influence of educational background (achieving university/college degree (high) or not (low)) on the outcomes of early RA, in terms of disease activity (DA
Nutrient fluxes from insect herbivory increase during ecosystem retrogression in boreal forest
Design of a new TDR probe to measure water content and electrical conductivity in highly saline soils
Purpose: The inappropriate irrigation is accelerating the soil salinization in western irrigation districts of China. The amelioration of salinized land must be based on large amount of water content and salinity data. Plastic coated TDR has been designed to measure water content accurately in highly saline soil, but the soil bulk electrical conductivity cannot be measured due to the coated materi
Siliceous Raw Material Exploitation at Hort de la Boquera Site (Margalef de Monsant, Tarragona, España) : First Results from La-Icp-Ms Analysis
Research on the sourcing of siliceous raw materials in Prehistory has taken a step forward with the addition of geochemical techniques and elemental analysis to the archaeopetrological method. Counter to the macroscopic techniques, which retain an elevated subjective percentage in their results, geochemical techniques and especially LA-ICP-MS analysis generate objective, quantifiable and usable da
High failure rate after internal fixation and beneficial outcome after arthroplasty in treatment of displaced femoral neck fractures in patients between 55 and 70 years : An observational study of 2,713 patients reported to the Norwegian Hip Fracture Register
Background and purpose — The treatment of patients between 55 and 70 years with displaced intracapsular femoral neck fracture remains controversial. We compared internal fixation (IF), bipolar hemiarthroplasty (HA) and total hip arthroplasty (THA) in terms of mortality, reoperations and patient-reported outcome by using data from the Norwegian Hip Fracture Register. Patients and methods — We inclu
Organic phosphorus in the terrestrial environment : a perspective on the state of the art and future priorities
Background: The dynamics of phosphorus (P) in the environment is important for regulating nutrient cycles in natural and managed ecosystems and an integral part in assessing biological resilience against environmental change. Organic P (Po) compounds play key roles in biological and ecosystems function in the terrestrial environment being critical to cell function, growth and reproduction. Scope:
Using Bayes Factors to Test Hypotheses in Developmental Research
This article discusses the concept of Bayes factors as inferential tools that can serve as an alternative to null hypothesis significance testing in the day-to-day work of developmental researchers. A Bayes factor indicates the degree to which data observed should increase (or decrease) the credibility of one hypothesis in comparison to another. Bayes factor analyses can be used to compare many ty
Vulnerability as a Key Concept in Museum Pedagogy on Difficult Matters
In recent years there has been an increasing interest in museum studies in exhibitions on what is termed Difficult Matters (Silvén and Björklund 2006)—such as rape and mass murder—and how such exhibitions may evoke ethical change. This raises the question about the conditions on which such exhibitions can lead to an ethical change. By developing a conceptual framework this article contributes to m
Influence of salinomycin treatment on division and movement of individual cancer cells cultured in normoxia or hypoxia evaluated with time-lapse digital holographic microscopy
Most studies on new cancer drugs are based on population-derived data, where the absence of response of a small population may pass unnoticed. Thus, individual longitudinal tracking of cells is important for the future development of efficient cancer treatments. We have used digital holographic microscopy to track individual JIMT-1 human breast cancer cells and L929 mouse fibroblast cultivated in
Impaired Cerebellar Maturation, Growth Restriction, and Circulating Insulin-Like Growth Factor 1 in Preterm Rabbit Pups
Cerebellar growth is impeded following very preterm birth in human infants and the observed reduction in cerebellar volume is associated with neurodevelopmental impairment. Decreased levels of circulating insulin-like growth factor 1 (IGF-1) are associated with decreased cerebellar volume. The relationship between preterm birth, circulating IGF-1, and key cell populations supporting cerebellar pro
Bra storlek på läkarutbildningen kräver djupare analys inom många områden.
Similar alpha and beta diversity changes in tropical ant communities, comparing savannas and rainforests in Brazil and Indonesia
Local biodiversity can be expected to be similar worldwide if environmental conditions are similar. Here, we hypothesize that tropical ant communities with different types of regional species pools but at similar habitat types in Brazil and Indonesia show similar diversity patterns at multiple spatial scales, when comparing (1) the relative contribution of alpha and beta diversity to gamma diversi
Utbildning utan lottning
Det är trångt i kön till läkarutbildningen. Därför har Lunds universitet beslutat att utgå från skolbetyg vid antagning till utbildningen och att använda högskoleprovresultat som skiljekriterium vid lika meriter. Det skriver Stefan Lindgren, programdirektör, Lena Sandberg, nämndsekreterare, och Nils Danielsen, ordförande för läkarprogrammet vid Lunds universitet.
Metabolites of Avena sativa with Blood Cholesterol Lowering Properties
Popular Science SummaryOat is one of the cereals that has been increasing in popularity during the last years. Oats are usually consumed for breakfast as a porridge, muesli, bread, or oat drinks which are included in, for example, smoothies. But why is it important to consume oats?There are two types of cholesterol, bad cholesterol and good cholesterol. The bad cholesterol can build up plaque insiCardiovascular diseases are among the most important causes of death in thedeveloped countries. These diseases are partly caused by too high cholesterolconcentrations in the blood. Avena sativa, oat, is the most common spieces of the genus Avena, and produced in huge amounts worldwide. Oats have been shown to have cholesterol-lowering properties since the 1960s. This property was originally attrib
Modelling and simulation of a coal-fired power plant for start-up optimisation
The increased impact from fluctuating energy sources like wind and photovoltaics significantly affects the operational regime of conventional power plants. In the near future, even former base load power plants such as the large-scale lignite plants in Germany will need to start and shut down to balance the electricity system. As frequent starts were not in the focus of optimisation in the past, a
Selfiekulturen i sociala medier
Fotograferandet är en av alla de otaliga praktiker som i grunden har förändrats med digitaliseringen och de sociala medierna. Tidigare fotograferade folk företrädesvis i samband med högtider och semesterresor och bilderna hamnade i det privata familjealbumet. Idag bär vi ständigt med oss kameran i mobiltelefonen och knäpper bilder som aldrig förr, vilket har lett till en ”avsakralisering” och ett
Situating Faculty Development in the Clinical Workplace
Medical students’ access to clinical supervision when rotating through hospital workplaces and the quality of that supervision are and have been an area of growing professional and societal concern. Increased training measures targeted at supervising physicians have been suggested to address this issue. Traditionally, such training has focused on offering physicians opportunities to develop as sup
