Sökresultat

BACKGROUND: Dysfunctions of the ubiquitin proteasome system (UPS), including the highly abundant neuronal enzyme ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), and autophagy-related changes (lysosomal degradation) are implicated in several neurodegenerative disorders including Alzheimer's disease (AD).METHOD: This study evaluated cerebrospinal fluid (CSF) levels of UCH-L1, protein deglycase (D

BACKGROUND: The discovery that heterozygous missense mutations in the gene encoding triggering receptor expressed on myeloid cells 2 (TREM2) are risk factors for Alzheimer's disease (AD), with only the apolipoprotein E (APOE) ε4 gene allele conferring a higher risk, has led to increased interest in immune biology in the brain. TREM2 is expressed on microglia, the resident immune cells of the brain

Background: Activation of the renin-angiotensin-aldosterone-system (RAAS) has been proposed to contribute to development of vascular complications in type 2 diabetes (T2D). The aim of the present study was to determine if plasma renin levels are associated with the severity of vascular changes in subjects with and without T2D. Methods: Renin was analyzed by the Proximity Extension Assay in subject

Background: Associations between BMI and DNA methylation of hypoxia-inducible factor 3-alpha (HIF3A) in both blood cells and subcutaneous adipose tissue (SAT) have been reported. In this study, we investigated associations between BMI and HIF3A DNA methylation in the blood and SAT from the same individuals, and whether HIF3A gene expression in SAT and skeletal muscle biopsies showed associations w

Popular science summaryWater is very important for life. In order to survive every organism needs to control the amount of water in its cells. One of the main ways the cell regulates its water content is through aquaporins. Aquaporins are membrane proteins that allow water and/or small neutral molecules to enter or exit the cell. Aquaporins form a large family and are present in all life forms, hoAbstractAquaporins are membrane integral proteins that facilitate the transport of waterand/or other small neutral molecules across biological membranes in cells in allforms of life. Among the subfamilies of aquaporins in higher plants, the X IntrinsicProteins (XIPs) are the most recently discovered subfamily and the leastcharacterized. However, the aromatic/arginine (ar/R) selectivity filter and

We study the structure-function relationship of alumina supported platinum during the formation of ammonia from nitrogen oxide and dihydrogen by employing in situ X-ray absorption and Fourier transform infrared spectroscopy. Particular focus has been directed towards the effect of oxygen on the reaction as a model system for emerging technologies for passive selective catalytic reduction of nitrog

With our sights set on a simple and inexpensive diagnostics device based on extraction and enrichment of parasites from human blood, we present a device design that relies on a combination of multiple different deterministic lateral displacement arrays. Our end goal is a microfluidic device that will be easy to use in the rural, resource-deprived areas where simple-to-use medical tools are crucial

We develop a theoretical model to describe structural effects on a specific system of charged colloidal polystyrene particles, upon the addition of non-adsorbing PEG polymers. This system has previously been investigated experimentally, by scattering methods, so we are able to quantitatively compare predicted structure factors with corresponding experimental data. Our aim is to construct a model t

This paper describes an extensive propagation channel measurement campaign in a warehouse environment for line-of-sight (LOS) and nonline-of-sight (NLOS) scenarios. The measurement setup employs a vector network analyzer operating in the 2-8-GHz frequency band combined with an 8×8 virtual multiple-input multiple-output (MIMO) antenna array. We develop a comprehensive statistical propagation channe

Conditional random fields were trained to detect marker words for negation and speculation in two corpora belonging to two very different domains: clinical text and consumer review text. For the corpus of clinical text, marker words for speculation and negation were detected with results in line with previously reported interannotator agreement scores. This was also the case for speculation marker

During the last thirty years, the Evangelical relationship with the State of Israel has drawn much academic and popular attention, particularly from historical, theological, and political perspectives. This dissertation engages with this literature but also complements it with an ethnographic account of the discursive practices of Evangelical Zionists through which, it is suggested, much of the re

Förbränning är både vår största källa till energi och ett stort hot mot miljön i form av föroreningar och växthusgaser. Ett par av de stora bovarna i sammanhanget är koldioxid och kväveoxider och de stora mängderna av dessa i atmosfären. Där bidrar koldioxid till den globala uppvärmningen i egenskap av växthusgas. Kväveoxider påverkar både miljö och människors hälsa negativt genom att bilda marknäCombustion of fuels is a major source of energy and at the same time a threat to the environment. Carbon dioxide (CO2) emissions are one of the obstacles on the route to cleaner energy. Combining Carbon Capture and Storage-technology (CCS) with use of biofuels lead to a negative net release of CO2 can be achieved. With some CCS-techniques the CO2 is repurposed in the combustion process together wi

This paper is based on ethnographic field work in an evangelical/Messianic community in contemporary Jerusalem. In the paper I interpret the pro-Israeli strand of Evangelicalism’s fascination with Judaica and Jewish ritual in relation to the movement’s location in a temporal-spatial interspace. I argue that the Christian Zionist impulse to experiment with Jewish tradition needs to be understood as

We have investigated the properties in water of two tetraalkylammonium bromides (tetramethylammonium, TMA+, and tetrapropylammonium, TPA+), at 0.4 M, using neutron scattering coupled with empirical potential structure refinement to arrive at an atomistic description. Having both a polar and an apolar moiety, it is of interest to determine the strength of each moiety as a function of the alkyl chai