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Aspects on optimisation of drug therapy in the elderly

Introduction: Elderly patients often use many drugs, increasing the risk for drug-related problems. Aim: To optimise drug therapy in the elderly by identifying, resolving and preventing drug-related problems. Methods: (Paper I) Medication reviews were conducted on nursing home patients’ with epilepsy or Parkinson’s disease by a multi-speciality team, whom identified drug-related problems and whe

Optical solitons in semiconductor quantum dot waveguides

A theory of self-induced transparency for a TM-mode propagating in a planar semiconductor waveguide sandwiched between two dielectric media is developed. A transition layer between the waveguide and one of the connected media is described using a model of a two-dimensional sheet of quantum dots. Explicit analytical expressions for the optical soliton in the presence of single-excitonic and biexcit

Costimulation blockade in transplantation of nerve allografts: long-term effects.

Costimulation blockade can prevent rejection of nerve allografts in short-term studies. We tested if costimulation blockade also prevented rejection of nerve allografts in long-term experiments, thereby improving functional recovery. A 7-mm sciatic nerve defect in C57/BL6 mice was bridged either by nerve allografts from Balb/C mice or by isogenic nerve grafts (isografts) from C57/BL6 mice. Costimu

Microbiology of the infected knee arthroplasty: Report from the Swedish Knee Arthroplasty Register on 426 surgically revised cases.

Surgically revised deep infected primary knee arthroplasties reported to the Swedish knee arthroplasty register during the years 1986-2000 were studied with respect to microbiology, antimicrobial susceptibility pattern and changes over time. In early, delayed and late infections, coagulase-negative staphylococci (CoNS) were most prevalent (105/299, 35.1%), and twice as common as Staphylococcus aur

Contrasting two models of academic self-efficacy – domain-specific versus cross-domain– in children receiving and not receiving special instruction in Mathematics

In social cognitive theory, self‐efficacy is domain‐specific. An alternative model, the cross‐domain influence model, would predict that self‐efficacy beliefs in one domain might influence performance in other domains. Research has also found that children who receive special instruction are not good at estimating their performance. The aim was to test two models of how self‐efficacy beliefs influ

Fibrinogen measurement in cardiac surgery with cardiopulmonary bypass: Analysis of repeatability and agreement of Clauss method within and between six different laboratories

Plasma fibrinogen concentration is important for coagulopathy assessment, and is most commonly measured using the Clauss method. Several factors, including device type and reagent, have been shown to affect results, The study objective was to evaluate performance and repeatability of the Clauss method and to assess differences between measurements performed during and after cardiopulmonary bypass

Joint Fundamental Frequency and Order Estimation using Optimal Filtering

Abstract in UndeterminedIn this paper, the problem of jointly estimating the number of harmonics and the fundamental frequency of periodic signals is considered. We show how this problem can be solved using a number of methods that either are or can be interpreted as filtering methods in combination with a statistical model selection criterion. The methods in question are the classical comb filter

Acute Effects of a Spinach Extract Rich in Thylakoids on Satiety: A Randomized Controlled Crossover Trial

Objective: By retarding fat digestion, thylakoids, the internal photosynthetic membrane system of green plants, promote the release of satiety hormones. This study examined the effect of consuming a single dose of concentrated extract of thylakoids from spinach on satiety, food intake, lipids, and glucose compared to a placebo. Design: Sixty overweight and obese individuals enrolled in a double-bl

Electrostatic interactions play an essential role in the binding of oleic acid with a-lactalbumin in the HAMLET-like complex: A study using charge-specific chemical modifications

Human a-lactalbumin made lethal to tumor cells (HAMLET) and its analogs are partially unfolded protein-oleic acid (OA) complexes that exhibit selective tumoricidal activity normally absent in the native protein itself. To understand the nature of the interaction between protein and OA moieties, charge-specific chemical modifications of lysine side chains involving citraconylation, acetylation, and

Measurement of the inelastic proton-proton cross-section at root s=7 TeV with the ATLAS detector

The dependence of the rate of proton-proton interactions on the centre-of-mass collision energy, root s, is of fundamental importance for both hadron collider physics and particle astrophysics. The dependence cannot yet be calculated from first principles; therefore, experimental measurements are needed. Here we present the first measurement of the inelastic proton-proton interaction cross-section

Effects of Added Surfactant on Swelling and Molecular Transport in Drug-Loaded Tablets Based on Hydrophobically Modified Poly(acrylic acid)

A combination of NMR chemical shift imaging and self-diffusion experiments is shown to give a detailed molecular picture of the events that occur when tablets of hydrophobically modified poly(acrylic acid) loaded with a drug (griseofulvin) swell in water in the presence or absence of surfactant (sodium octylbenzenesulfonate). The hydrophobic substituents on the polymer bind and trap the surfactant

Extraction of water-soluble hemicelluloses from barley husks.

Heat treatment of barley husks was performed to extract arabinoxylan with high yield and high weight-averaged molecular mass (M(W)). Microwave irradiation was employed for initial screening of suitable residence times (2-15min), temperatures (120-210 degrees C) and initial pH (3-13) of the reaction slurry. Microwave irradiation was shown to be a good method for predicting the effects of heat treat

Epidemiological aspects of ankylosing spondylitis in Sweden. Characterization, prevalence and prognosis

Ankylosing Spondylitis (AS) is a chronic, potentially disabling, inflammatory disease that poses a longstanding burden on the patient and the society. The epidemiology of AS in Sweden has not been extensively studied previously. Radiographic and self-perceived health information from 1,005 men aged 69-81 years, showed a prevalence of moderate to severe radiographic sacroiliitis of 1.4% (95% Confid

Analytical model of beach erosion and overwash during storms

During severe storms high waves and water levels may greatly impact the sub-aerial portion of the beach inducing significant morphological change at elevations that the waves can not reach under normal conditions. Morphological formations such as dunes and barrier islands may suffer from direct wave impact and erode. Overwash occurs if the wave run-up and/or the mean water level are sufficiently h