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A combination of genetic and functional approaches has identified three independent breast cancer risk loci at 2q35. A recent fine-scale mapping analysis to refine these associations resulted in 1 (signal 1), 5 (signal 2), and 42 (signal 3) credible causal variants at these loci. We used publicly available in silico DNase I and ChIP-seq data with in vitro reporter gene and CRISPR assays to annotat

Ribonucleotide reductase (RNR) is an essential enzyme with a complex mechanism of allosteric regulation found in nearly all living organisms. Class I RNRs are composed of two proteins, a large α-subunit (R1) and a smaller β-subunit (R2) that exist as homodimers, that combine to form an active heterotetramer. Aquifex aeolicus is a hyperthermophilic bacterium with an unusual RNR encoding a 346-resid

Background: Patients with bladder pain syndrome experience debilitating pain and extreme frequency of urination. Numerous therapeutic approaches have been tested, but as the molecular basis of disease has remained unclear, specific therapies are not available. Objective: Recently, a systematic gene deletion strategy identified interleukin-1 (IL-1) hyperactivation as a cause of severe cystitis in a

Longer follow-up and new trial data from phase 3 randomised controlled trials investigating immune checkpoint blockade (PD-1 or its ligand PD-L1) in advanced clear-cell renal cell carcinoma (RCC) have recently become available. The CheckMate 9ER trial demonstrated an improved progression-free survival (PFS) and overall survival (OS) benefit for the combination of cabozantinib plus nivolumab. A Key

The recent randomized controlled phase III CLEAR trial results are the last to complement immune checkpoint inhibitor (ICI)-based doublet combination therapies for treatment-naïve metastatic clear-cell renal cell carcinoma. The CLEAR trial demonstrated an improved progression-free survival (PFS), overall survival (OS), and an objective response rate (ORR) benefit for the combination of lenvatinib

Miniature hyperspectral and thermal cameras onboard lightweight unmanned aerial vehicles (UAV) bring new opportunities for monitoring land surface variables at unprecedented fine spatial resolution with acceptable accuracy. This research applies hyperspectral and thermal imagery from a drone to quantify upland rice productivity and water use efficiency (WUE) after biochar application in Costa Rica

Properties of the Grain-128AEAD key re-introduction, as part of the cipher initialization, are analyzed and discussed. We consider and analyze several possible alternatives for key re-introduction and identify weaknesses, or potential weaknesses, in them. Our results show that it seems favorable to separate the state initialization, the key re-introduction, and the A/R register initialization into

Introduction: Tension band wiring of olecranon fractures has high reported rates of complications and reoperations. We aimed to compare classic tension band wiring to cerclage fixation without K-wires in the treatment of displaced olecranon fractures in elderly patients. The primary outcome was reoperation. Secondary outcomes included complications and patient reported outcomes. Outcomes following

Weaknesses in the Grain-128AEAD key re-introduction, as part of thecipher initialization, are analyzed and discussed. We consider and analyzeseveral possible alternatives for key re-introduction and identify weaknesses, or potential weaknesses, in them. Our results show that it seemsfavorable to separate the state initialization, the key re-introduction, andthe A/R register initialization into thr

We study a non-autonomous differential equation describing the one-dimensional motion of a particle interacting with a charged source at the origin. The charge of the source is piece-wise constant; it alternates between two different values, one being positive and the other being negative. We show that the alternation of the charge enriches the behaviour of the system, exhibiting qualitatively new

Background: There is a lack of studies of amyotrophic lateral sclerosis (ALS) in immigrants. Objective: The objective is to study the association between country of birth and incident ALS in first-generation immigrants versus Swedish-born individuals, and in second-generation immigrants versus native Swedes. Methods: Study populations included all adults aged 18 years and older in Sweden, in the f

Purpose: Irritant contact dermatitis (ICD) is a major cause of occupational disease. The aim was to review the relation between exposure to occupational irritants and ICD and the prognosis of ICD. Methods: Through a systematic search, 1516 titles were identified, and 48 studies were included in the systematic review. Results: We found that the evidence for an association between ICD and occupation

Background: Compression of the greater occipital nerve (GON) may contribute to chronic headache, neck pain, and migraine in a subset of patients. We aimed to evaluate whether GON decompression could reduce pain and improve quality of life in patients with occipital neuralgia and chronic headache and neck pain. Methods: In this retrospective cohort study, selected patients with neck pain and headac

Motivated by the influence of deformation-induced microcracks on the effective electrical properties at the macroscale, an electro-mechanically coupled computational multiscale formulation for electrical conductors is proposed. The formulation accounts for finite deformation processes and is a direct extension of the fundamental theoretical developments presented by Kaiser and Menzel (Arch Appl Me

The concept of optic flow, a global pattern of visual motion that is both caused by and signals self-motion, is canonically ascribed to James Gibson's 1950 book "The Perception of the Visual World." There have, however, been several other developments of this concept, chiefly by Gwilym Grindley and Edward Calvert. Based on rarely referenced scientific literature and archival research, this article