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Combined quantum mechanics and molecular mechanics (QM/MM) calculations are a popular approach to study reaction mechanisms of enzymes. However, recently, the reproducibility of such calculations has been questioned, comparing the results of two software: NWChem and Q-Chem. Here, we continue and extend this study by including three additional software─ComQum, ORCA, and AMBER─using the same test ca
Introduction: Obesity is a chronic, progressive, and recurring disease that contributes significantly to multimorbidity across Europe. Despite the publication of numerous clinical practice guidelines (CPGs) for obesity, many chronic disease guidelines for obesity related diseases such as diabetes, MASLD, heart disease, obstructive sleep apnea do not integrate contemporary understandings of obesity
The Nordic countries have been described as generous front-runners in their development assistance, making observers suggest the existence of a ‘Nordic Model’. They have been claimed to play a leadership role in a European and global context. Recently, however, this characterisation has been challenged due to changes in Nordic policies and in the external environment. We investigate the developmenThe Nordic countries have been described as generous front-runners in their development assistance, making observers suggest the existence of a ‘Nordic Model’. They have been claimed to play a leadership role in a European and global context. Recently, however, this characterisation has been challenged due to changes in Nordic policies and in the external environment. We investigate the developmen
Perturbed secretion of insulin and other pancreatic islet hormones is the main cause of type 2 diabetes (T2D). The islets harbor five cell types that are potentially altered differently by T2D. Whole-islet transcriptomics and single-cell RNA-sequencing (scRNAseq) studies have revealed differentially expressed genes without reaching consensus. Here, we demonstrate that further insights into T2D dis
Intelligence scholars have described the contemporary availability ofOpen-Source Intelligence (OSINT) and the entrance of civil society actorsinto the field of intelligence as a “democratization of intelligence”, therebyportraying a fundamentally positive and inclusive enterprise. Assessingthe implications of the recent explosion of OSINT groups and activists fortraditional state intelligence acto
This paper examines the impact of artificial intelligence (AI)-enabled technologies on employee pay in the United Kingdom. We use matched nationally representative data from the Employers’ Digital Practices at Work Survey and an original survey of 6000 UK workers and apply machine learning techniques to uncover relationships between AI technology and employee pay across qualification and occupatio
This study explore how visitors experience "time travel" at an open-air museum, focusing on reconstructed buildings at Fredriksdal Museums and gardens in Helsingborg. Through interviews, observations and thematic coding the research identifies elements that enhance the sense of historical immersion. Using David Kolb's experiential learning theory the analysis reveal that learning occ
Syftet med min uppsats är att undersöka hur typograferna upplevde övergången i tryckteknik mellan högtryck och offsettryck. Inledningsvis beskrivs skiftet till offsettryck och de konsekvenser som följde. Undersökningen utgår från respondenternas utsagor om teknikskiftet. I min kvalitativa analys har jag använt Bosse Angelöws teori om övergångsprocesser med individen i centrum, för att försöka förs
Avhandlingen undersöker föreningar i Sverige som organiserar öppna verkstäder. Öppna verkstäder, vilka också kallas för makerspaces, är platser som möjliggör skapande. Verktyg, maskiner och kunskap är delade mellan användarna. Syftet med avhandlingen är att undersöka hur föreningar organiserar sina delade verkstäder, vilka svårigheter föreningarna möter samt vilka implikationer detta har för den bAlternative building as an interstitial mode of transformation plays a central role in the discussion of strategies for degrowth. In this debate the questions of how alternative projects can be scaled up and how degrowth politics can gain broad societal support have been identified as crucial. In this context open workshops – grassroots infrastructures for creative activities, such as repair, upcy
In cold regions, snow cover and seasonally frozen ground (SFG) exert a substantial influence on hydrological processes, yet their effects – especially at the scale of large basins – remain insufficiently understood due to limited observations and process-based analyses. To address this, we extended the widely used Grid Xinanjiang (GXAJ) hydrological model by developing two physically meaningful ye
From Seedlings to Solutions: Which Test Will Sprout Success? Type 1 diabetes (T1D) is a condition in which the body attacks its own cells that produce insulin, a necessary hormone that allows us to use energy from food. People who do not have insulin are unable to process sugar effectively, which causes major health problems. Since there is currently no cure for this condition, affected individua
Denna studie analyserar tillämpningen av artikel 22 i Europaparlamentets och rådets förordning (EU) 2016/679 (GDPR) på kreditupplysningsverksamhetens kreditbedömning i form av kreditbetyg. Fokus är att identifiera juridiska möjligheter och utmaningar i dessa processer. Särskild vikt läggs vid transparensbestämmelserna i artiklarna 13–15 i GDPR. Automatiserade verktyg för kreditupplysningar är baseThis study analyzes the application of Article 22 of Regulation (EU) 2016/679 of the European Parliament and of the Council (GDPR) to the credit assessment practices of the credit reporting businesses in the form of credit score. The main focus is on identifying the legal opportunities and challenges in these processes. Particular attention is paid to the transparency provisions in Articles 13–15
The European Green Deal (EGD) aims for agriculture to contribute positively to climate change mitigation and nature preservation while meeting growing societal needs for food, energy, and biomaterials. Delivering comprehensive policy action efficiently requires decision-support tools to assess the outcomes of interventions across multiple, and potentially conflicting, goals. By means of agent-base
This study explores the online communication strategies of anti-tourism movements to evaluate their potential contributions to place branding—a topic that has received limited scholarly attention. While prior research often views such movements as antagonistic to place branding efforts, we challenge this assumption. Through an analysis of nine movements across five countries, we apply the typology
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains one of the deadliest infectious diseases worldwide. In 2023, it accounted for approximately 1.25 million deaths, including 161,000 among individuals living with HIV, making it the leading cause of death from a single infectious agent. The growing prevalence of multidrug-resistant TB (MDR-TB) further complicates treatment and contribu
A substantial external force transmitted to the brain may cause a severe traumatic brain injury (sTBI) , resulting in structural brain damage and/or functional impairment. Despite progress in management, traumatic brain injury remains a major cause of severe disability and death. This thesis evaluates treatment strategies and novel interventions in children and adults with sTBI and comprises the f
We build on the predictive processing framework to show that intelligent behaviour is adaptive control, driven by accurate prediction and uncertainty reduction in dynamic environments with limited information. We argue that adaptive control arises through a process of re-concretisation, where learned abstractions are grounded in new situations via embodiment. We use this as an explanation of why A
Mitochondria are most known as producers of ATP and for their metabolic functions in eukaryotic cells. However, these are not the only roles of these organelles, as they also have the means to communicate with the nucleus. These signals going from mitochondria to the cell nucleus are termed mitochondrial retrograde signaling or regulation (MRR). In Arabidopsis thaliana, the master regulator of MRR
