PURPOSE: Hereditary prostate cancer accounts for 5% to 10% of all prostate cancer cases. We assessed clinical characteristics and survival in patients with hereditary prostate cancer MATERIALS AND METHODS: The study comprised 201 patients from 62 Swedish hereditary prostate cancer families and 402 controls with prostate cancer who were matched for age and calendar year at diagnosis, and the hospit

In a long-term and global perspective irrigated and terraced landscapes, landesque capital, have often been assumed to be closely associated with hierarchical political systems. However, research is accumulating that shows how kinship-based societies (including small chiefdoms) have also been responsible for constructing landesque capital without population pressure. We examine the political econo

Orbital-specific femtosecond charge transfer dynamics between Fe(II)-tetraphenylporphyrin molecules and semimetallic molybdenum disulfide substrates is investigated using core-level resonant photoemission spectroscopy. The electronic coupling to the substrate and the efficiency of charge transport across the interface is found to be different for the individual molecular electronic subsystems. In

Platform development provides software organisations with means to quickly respond to changing consumer needs. Product reuse and improved development efficiency can be achieved if platform development is introduced. A major challenge when using software platforms to produce a variety of products is to keep a high quality of the platform throughout the development of the products. It is therefore

Resonance scattering techniques are very useful for high-resolution atomic spectroscopy. The applicability of these techniques has been much extended, particularly through the rapid development of tunable-laser technology. The use of a narrowband tunable laser, acting on a collimated atomic beam, gives a direct method enabling, for example, hyperfine structure and isotope shift studies. The intens

1. The influence of light, temperature, sediment mixing and sediment origin (water depth) on the recruitment of the cyanobacterium Gloeotrichia echinulata was examined in the laboratory. 2. Light and temperature were the most important factors initiating germination in G. echinulata. 3. The extent of germination (recruited biovolume) was mainly regulated by temperature and sediment mixing. Further

Supersingular H-n rank one perturbations of an arbitrary positive self-adjoint operator A acting in the Hilbert space H are investigated. The operator corresponding to the formal expression A(alpha) = A + alpha(phi,.)phi, alpha is an element of R, phi is an element of H-n (A), is determined as a regular operator with pure real spectrum acting in a certain extended Hilbert space H superset of X The

Popular Abstract in Swedish Syftet med denna studie var att: (I) undersöka förekomsten av höftartros på Island i jämförelse med södra Skandinavien, (II) utreda frekvensen av operation med total höftledsplastik (THP) för artros på Island, (III) jämföra två olika metoder för bedömning av höftartros med röntgenbilder, (IV) i en populationsbaserad studie påvisa förekomsten av ärftlighet för höftartrosHereditary factors are suggested to contribute to osteoarthritis (OA), but their relative importance is uncertain. Moreover, the underlying specific variations at the genome level remain unknown. The prevalence of hip OA in Iceland was assessed by examining colon radiographs and was found to be at least 5-fold higher compared to Sweden and Denmark. The age-standardized incidence of total hip repl

Four conserved disulfide bonds and N-linked and O-linked glycans of extracellular fungal peroxidases have been identified from studies of a lignin and a manganese peroxidase from Trametes versicolor, and from Coprinus cinereus peroxidase (CIP) and recombinant C. cinereus peroxidase (rCIP) expressed in Aspergillus oryzae. The eight cysteine residues are linked 1-3, 2-7, 4-5 and 6-8, and are located

BACKGROUND: Inflammation and immune responses are considered to be very important in the pathogenesis of atherosclerosis. Lipid accumulation in macrophages of the arterial intima is a characteristic feature of atherosclerosis which can influence the inflammatory potential of macrophages. We studied the effects of lipid loading on the regulation of TNF expression in human monocyte-derived macrophag

Over the last two decades there has been a striking and continuous increase in the prevalence of obesity both in industrialized and developing countries. Despite this global consistency there is a variation within countries with a higher prevalence of obesity within rural areas. The overall aim was to explore the prevalence of obesity and factors that influence the development of obesity in a rura

When water is coadsorbed with oxygen at coverages above 0.25ML an intact water species is observed in high resolution X-ray photoelectron spectroscopy up to 220 K, which is significantly more stable than intact water on the clean surface. The presence of this species causes a shift in the O 1s binding energy of the pre-adsorbed oxygen, which indicates the formation of hydrogen bonds between the tw

Polyamine analogues have demonstrated anti-tumour activity in a number of solid tumour models. In the present study we compared the cytotoxicities of three polyamine analogues against four breast cancer cell lines. All cell lines are derived from tumours of women with breast cancer and, although we are sampling just a small number of tumours, they represent a spectrum of the genetic plethora of br