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Individuals are less likely to make morally desirable decisions when they are in groups. I study when this phenomenon makes groups less likely to produce a morally desirable outcome than one individual alone. I formulate and test a model in which a moral outcome occurs if at least one individual makes a costly decision. Using a lab experiment and data from field experiments on the bystander effect
Prolonged hydrothermal treatment for sulfonated poly(ether ether ketone) membranes induces mechanical degradation and developing hydrophilic-hydrophobic phase separation, simultaneously. The enhanced phase separation provides incremental proton conductivity to the membranes, whereas mechanical degradation drastically reduces device stability. On this basis, we describe here the effects of two diff
Aquaporins (AQPs) are water channels embedded in the cell membrane that are critical in maintaining water homeostasis. We describe a protocol for determining the water permeation capacity of AQPs reconstituted into proteoliposomes. Using a stopped-flow setup, AQP embedded in proteoliposomes are exposed to an osmogenic gradient that triggers water flux. The consequent effects on proteoliposome size
This protocol describes the design and use of CRISPRi-mediated transcriptional silencing in human iPSCs, for loss-of-function studies in brain development research. The protocol avoids single cell selection, thereby eliminating side effects of clonal expansion and sites of viral integration. We also describe a neural progenitor differentiation protocol and discuss the challenges of target-specific
Aquaporin water channels (AQPs) are membrane proteins that maintain cellular water homeostasis. The interactions between human AQPs and other proteins play crucial roles in AQP regulation by both gating and trafficking. Here, we describe a protocol for characterizing the interaction between a human AQP and a soluble interaction partner using microscale thermophoresis (MST). MST has the advantage o
Aims: To accommodate surplus energy, adipose tissue expands by increasing both adipose cell size (hypertrophy) and cell number (hyperplasia). Enlarged, hypertrophic adipocytes are known to have reduced insulin response and impaired glucose transport, which negatively influence whole-body glucose homeostasis. Rosiglitazone is a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, known
The exact spatial and temporal behaviour of rapid climate shifts during the Last Glacial– Interglacial Transition are still not entirely understood. In order to investigate these events, it is necessary to have detailed palaeoenvironmental reconstructions at geographically spread study sites combined with reliable correlations between them. Tephrochronology, i.e., using volcanic ash deposits in ge
Background: In Norway, 5-10% of neonates and infants have biomarkers suggesting vitamin B12 deficiency from newborn screening tests and unselected clinical screening, respectively. Aims: The aims were to identify risk factors and describe presenting symptoms and biochemical profiles in infants diagnosed with vitamin B12 deficiency. Methods: In this case-control study, we searched hospital medical
This paper presents some of the results of the project, EXTOOL, Experience Curves: A Tool for Energy Policy Programmes Assessment, funded by the European Commission. The objective of the project was to analyse the experience curve as a tool for the assessment of energy policy measures. This is of special interest, since the use of experience curves for the assessment of energy policy measures requ
The objective of this study was to improve the understanding of the use of different experience curves in energy analysis. The study was based on the application of experience curves to wind power systems, but the approach is generic and can be used in other energy technologies. In the study, experience curves for wind power were developed, and it has been demonstrated that different types of expe
This chapter explores the connections between the concepts of sustainable urban transformation and the green urban economy, proposes a framework for understanding how these concepts ‘fit’ together, and makes some practical suggestions for local governments and for national and international policy.
Spent sulfite liquor (SSL) from softwood processing is rich in hemicellulose (acetyl galactoglucomannan, AcGGM), lignin, and lignin-derived compounds. We investigated the effect of sequential AcGGM purification on the enzymatic bioconversion of AcGGM. SSL was processed through three consecutive purification steps (membrane filtration, precipitation, and adsorption) to obtain AcGGM with increasing
Abstract We address the uncertain outcomes of diversity work in organizations by showing that diversity management does not let itself be reduced to a matter of success and failure. Drawing upon theories of ambiguities in organizations and 2.5 years of longitudinal fieldwork in a Swedish municipality, we show that ambiguities characterize diversity work, including what diversity encompasses, the g
