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Human epidermal growth factor receptor 2 (HER2) is a clinically validated target for breast cancer therapy. Previously, a drug-fused HER2-targeting affinity protein construct successfully extended the survival of mice bearing HER2-expressing xenografts. The aim of this study was to evaluate the influence of the number and positioning of the protein domains in the drug conjugate. Seven HER2-targeti
Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of induced T changes by measuring fasting amino acid (AA) levels in a human model, in which short-term
Background: The aim of this study was to explore the risk of invasive colorectal cancer (CRC) in relatives of patients with colorectal carcinoma in situ (CCIS), which is lacking in the literature. Patients and Methods: We collected data from Swedish family-cancer datasets and calculated standardized incidence ratio (SIR) and cumulative risk of CRC in family histories of CCIS in first- and second-d
Hydropower is one of the significant renewable energy resources. It is regularly requested at peak time steps to meet the load requirements of power systems resources allocation. Therefore, modeling the optimal operation of hydropower systems to maximize the entire energy production of reservoir systems can be a vital task for energy investment. Deriving optimal unknown decision parameters of thes
Laminar burning velocity of lean methane/air flames exposed to pulsed microwave irradiation is determined experimentally as part of an effort to accurately quantify the enhancement resulting from exposure of the flame to pulsed microwaves. The experimental setup consists of a heat flux burner mounted in a microwave cavity, where the microwave has an average power of up to 250 W at an E-field in th
Quantitative text analysis is a growing research field in political science, whereas very few combine survey experiments with in-depth analysis of citizens’ word expressions. This chapter illustrates how a survey experiment and a latent semantic analysis are successfully combined in analyzing the 2016 EU referendum in Great Britain (Brexit). This example combines an analysis of semantic cluster ap
People are commonly expected not to waste their vote on parties with small probabilities of being elected. Yet, many end up voting for underdogs. We argue that voters gauge the popular support for their preferred party from their social networks. When social networks function as echo chambers, a feature observed in real-life networks, voters overestimate underdogs' chances of winning. We conduct v
During a vote-decision process, citizens elect between some of the parties – not all of them. In this paper, we explore a potential strategic reason to include an additional alternative in the consideration set. Drawing on research from the field of strategic voting, we study incentives to defect to a party at risk of falling below an electoral threshold in order to elect a winning coalition (”ins
Breast cancer metastasis accounts for most of the deaths from breast cancer. Identification of germline variants associated with survival in aggressive types of breast cancer may inform understanding of breast cancer progression and assist treatment. In this analysis, we studied the associations between germline variants and breast cancer survival for patients with distant metastases at primary br
Tight-junction (TJ) proteins are essential for establishing the barrier function between neighbor epithelial cells, but also for recognition of pathogens or cell migration. Establishing the expression pattern and localization of different TJ proteins will help to understand the development and physiology of the airway. Here we identify that the junctional adhesion molecule 3 (Jam3) expression is r
Planar cell polarity (PCP) is evolutionary conserved and play a critical role in proper tissue development and function. During central nervous system development, PCP proteins exhibit specific patterns of distribution and are indispensable for axonal growth, dendritogenesis, neuronal migration, and neuronal differentiation. The retina constitutes an excellent model in which to study molecular mec
This study shows the distribution patterns of apoptotic cells and biomarkers of cellular senescence during the ontogeny of the retina in the zebra finch (T. guttata). Neurogenesis in this altricial bird species is intense in the retina at perinatal and post-hatching stages, as opposed to precocial bird species in which retinogenesis occurs entirely during the embryonic period. Various phases of pr
During vertebrate embryonic development, cellular senescence occurs at multiple locations. To date, it has been accepted that when there has been induction of senescence in an embryonic tissue, β-galactosidase activity is detectable at a pH as high as 6.0, and this has been extensively used as a marker of cellular senescence in vivo in both whole-mount and cryosections. Such senescence-associated
The visual system is affected by neurodegenerative diseases caused by the degeneration of specific retinal neurons, the leading cause of irreversible blindness in humans. Throughout vertebrate phylogeny, the retina has two kinds of specialized niches of constitutive neurogenesis: the retinal progenitors located in the circumferential marginal zone and Müller glia. The proliferative activity in the
The bird retina offers an excellent model to investigate the mechanisms that coordinate the morphogenesis, histogenesis, and differentiation of neuron and glial cells. Although these developmental features have been intensively studied in the chicken (Gallus gallus, Linnaeus 1758), a precocial bird species, little is known about retinogenesis in altricial birds. The purpose of this study was to ex
BACKGROUND: Senescence-associated β-galactosidase (SA-β-GAL) histochemistry is the most commonly used biomarker of cellular senescence. These SA-β-GAL-positive cells are senescent embryonic cells that are usually removed by apoptosis from the embryo, followed by macrophage-mediated clearance.RESULTS: Some authors have proposed that SA-β-GAL activity in differentiated neurons from young and adult m
Comparative developmental studies have shown that the retina of altricial fish and mammals is incompletely developed at birth, and that, during the first days of life, maturation proceeds rapidly. In contrast, precocial fish and mammals are born with fully differentiated retinas. Concerning birds, knowledge about retinal development is generally restricted to a single order of precocial birds, Gal
The LIM-homeodomain transcription factor Islet-1 (Isl1) has been widely used as a marker of different subtypes of neurons in the developing and mature retina of vertebrates. During retinal neurogenesis, early Isl1 expression is detected in the nuclei of neuroblasts that give rise to ganglion, amacrine, bipolar, and horizontal cells. In the mature retina, Isl1 expression is restricted to the nuclei
The aim of this special issue is to invite scholars in public administration to address issues of power in relation to evaluation practices in the public sector. Power is one of those big, difficult, and inherently nebulous concepts that both scholars and practitioners appear to consciously or unconsciously avoid. Our ambition in this introduction is not to present a comprehensive conceptual revieThe aim of this special issue is to invite scholars in public administration to address issues of power in relation to evaluation practices in the public sector. Power is one of those big, difficult, and inherently nebulous concepts that both scholars and practitioners appear to consciously or unconsciously avoid. Our ambition in this introduction is not to present a comprehensive conceptual revie
The LIM-homeodomain transcription factor Islet1 (Isl1) has been widely used as a marker of neuronal differentiation in the developing visual system of different classes of vertebrates, including mammals, birds, reptiles, and fish. In the present study, we analyzed the spatial and temporal distribution of Isl1-immunoreactive cells during Xenopus laevis retinal development and its relation to the fo
