Individuals with an inherited predisposition to cancer development are at an increased risk of developing multiple tumours. Hereditary non-polyposis colorectal cancer (HNPCC) is one of the most common hereditary cancer syndromes and is estimated to account for approximately 2% of colorectal cancers. However, HNPCC individuals are at an increased risk of developing other tumour types such as cancer

C1q deficiency is a rare condition associated with a systemic lupus erythematosus (SLE)-like syndrome and recurrent infections. Here we present the molecular basis behind C1q deficiency in three sisters of Inuit origin. Initial examination for complement deficiency showed no function of the classical complement activation pathway in the patients; the lectin and alternative pathways were intact. No

The main component of the sex pheromone precursor in females of Macrodiprion nemoralis was identified as a threo-3,7,9-trimethyl-2-tridecanol isomer, approximately 800 pg per female, by gas chromatography-mass spectrometry. Comparison of mass spectrometric ion chromatograms showed that the natural compound in the female extract has the same retention time and mass spectrum as one of the two synthe

To evaluate the cost-effectiveness of an additional 12-week treatment with varenicline for abstainers who had successfully completed an initial 12-week treatment. The Benefits of Smoking Cessation on Outcomes simulation model was used to simulate both direct and indirect effects of smoking cessation. All calculations were performed in 2003 Swedish prices. Sweden in 2003. The modelled cohort consis

A simple and easy-to-use extraction procedure has been optimised, validated, and applied for extraction of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in urine and spiked plasma samples. PhIP is a carcinogenic and mutagenic heterocyclic aromatic amine that is formed during cooking of meat and fish. The novelty of the extraction procedure lies in using a short piece of narrow capillary-l

Objective: Little is known about the etiology of small bowel carcinoid tumor (SBC), but a few studies have pointed to certain medical and lifestyle factors as potential risk factors. This study aims to evaluate these findings and to identify new associations. Methods: A population-based European multicenter case-control study was conducted from 1995 through 1997. Incident histologically verified 3

The spectral emission from thermographic phosphors in free flow and its dependence of laser energy per cross section area (laser fluence [J/cm(2)]) has been investigated. Temperature measurements in gaseous flows using thermographic phosphors require higher laser energy than measurements performed on surfaces, due to lower particle density. A troublesome systematic error associated with high fluen

The solubility in dilute aqueous solutions of amylose complexed with ionic surfactants has been investigated by turbidity measurements. The turbidity depended on both the amylose and the surfactant concentrations. Low and high surfactant concentrations resulted in macroscopic phase separation, while mixtures at intermediate surfactant concentrations remained monophasic for at least one month. The

Background. Infection with Helicobacter pylori is associated with an increased risk of gastric cancer. Several studies have indicated that the association differs with strain type. We aimed to find out if infection with strains lacking the virulence factor CagA is linked to gastric cancer risk. Materials and methods. In a hospital-based case-control study, we collected sera from 100 case patients

The present study examines whether foreign adoptees differ from normative samples in adult attachment status, and explores within-group differences associated with (in)secure attachment status in adult adoptees. Forty adoptees, from a previously representative study of foreign adoptees in Sweden, were interviewed with the Adult Attachment Interview (AAI). In adition, they were questioned about iss

An effect of permeabilisation and lyophilisation of the yeast cells Hansenula polymorpha on their electrochemical behaviour in the presence of mediators, substrates (formaldehyde, glucose, methanol, ethanol), and cofactors (NAD(+), NADP(+), NADH, NADPH, glutathione) has been studied. Two amperometric techniques differing in the cell immobilisation methods were applied. The cells of a wild strain (

Effects of anaerobic pre-treatment were evaluated on the dewatered-sewage sludge from a municipal wastewater treatment plant in order to improve its biodegradability through anaerobic digestion. The pre-treatment was conducted in laboratory scale at 25, 50 and 70 degrees C for an incubation time of two days. As a reference, sludge sample was also autoclaved at 121 degrees C for 20 min to determine

Plate heat exchangers have been playing important role in the power and process industries in the recent past. Hence, it is important to develop simulation strategies for plate heat exchangers accurately. This analysis represents the dynamic behaviour of the single pass plate heat exchangers, considering flow maldistribution from port to channel. In addition to maldistribution the fluid axial disp

Hypertension and its consequences on cognition was analyzed using data from the study "Men born in 1914" in Malmo, Sweden, a prospective cohort study of cardiovascular disease. The baseline examinations took place in 1982/83 where 500 men participated in extensive medical and social examinations. A neuropsychological investigation was completed including five standardized cognitive tests. The spec

Ovarian cancer is the leading cause of death from gynecologic malignancies among women worldwide. Little is known about reproductive factors or lifestyle determinants and ovarian cancer prognosis. The objective of this study was to examine whether ovarian cancer survival is influenced by reproductive history, anthropometric characteristics, prediagnostic life-style factors and family history or br