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OBJECTIVE To evaluate the pharmacokinetics, tolerability and effect on endocrinology of bicalutamide given as once-daily monotherapy at doses of > 150 mg to patients with locally advanced (MO) or metastatic (M1) prostate cancer, with efficacy as a secondary endpoint. PATIENTS AND METHODS Patients were initially enrolled to receive bicalutamide 300 mg in a non-randomized phase, after which further

Tropical forests, which play critical roles in global biogeochemical cycles, radiation budgets and biodiversity, have undergone rapid changes in land cover in the last few decades. This study examines the complex process of land cover change in the biodiversity hotspot of Western Ghats, India, specifically investigating the effects of conservation measures within the Indira Gandhi Wildlife Sanctua

The relationship between needs for care and support and subjective quality of life was investigated in a cross-sectional multi-center study including 418 individuals with schizophrenia from 10 centers in Nordic countries. Needs in 22 domains were investigated by interviews with key workers and their patients using the Camberwell Assessment of Need scale, and quality of life by the Lancashire Quali

We use both the civ3 and mchf codes to calculate oscillator strengths of allowed and intercombination lines in the 3s(2) 3p-3s3p(2) multiplets. Valence, core-valence and some core-core correlation effects are included. The two approaches give results in excellent agreement. Core effects are particularly important for the intercombination lines, though relatively minor for allowed transitions. We o

We report on the first theoretical investigation of M-F-dependent lifetimes due to interference between a magnetic octupole transition and a hyperfine induced electric quadrupole transition. Extensive multiconfiguration Dirac-Fock calculations are used to model the hyperfine quenching of the magnetic octupole decay of 3d(9)4s D-3(3) and the state mixing between the D-3(3) and D-3(2) due to hyperfi

Traditionally, traffic and activation of eosinophils in asthmatic airways are thought to take place during the late-phase allergic reaction. The present study tests the hypothesis that when eosinophils are present in the tissue before allergen exposure, as in chronically inflamed asthmatic airways, acute anaphylactic reactions initiate an eosinophil response. Using a guinea-pig allergic model, whe

[1] In mires, which occupy large areas of the boreal region, net ecosystem CO2 exchange ( NEE) rates vary significantly over various timescales. In order to examine the effect of one of the most influencing variables, the water table depth, on NEE the general ecosystem model GUESS-ROMUL was modified to predict mire daily CO2 exchange rates. A simulation was conducted for a lawn, the most common mi

A generally accepted way of building passive houses has been to have small windows facing north and large windows to the south. This is to minimize losses on the north side while gaining as much solar heat as possible on the south. ln spring 2001, 20 terraced houses were built outside Gothenburg partly in this way. The indoor temperature is kept at a comfortable level by passive methods, using sol

The authors report on magnetotransport investigations of nanoscaled ferromagnetic Co/Ni/Co single electron transistors. As a result of reduced size, the devices exhibit single electron transistor characteristics at 4.2 K. Magnetotransport measurements carried out at 1.8 K reveal tunneling magnetoresistance (TMR) traces with negative coercive fields, which the authors interpret in terms of a switch

We have characterized three CoA-independent types of enzyme, phospholipases, phospholipid:diacylglycerol acyltransferases (PDATs) and cholinephosphotransferases, responsible for the removal of unusual fatty acids from phosphatidylcholine (PC) in microsomal preparations from developing oil seeds. The metabolism of sn-2-[(14)C]acyl-PC was monitored in microsomal preparations from various oilseeds ha

OBJECTIVE: We sought to establish references ranges and to test the hypothesis that biochemical tissue-specific markers for the heart in umbilical cord blood of newborns with cardiac defects and intrauterine growth restriction (IUGR) are abnormal. STUDY DESIGN: A prospective study was conducted. Serum samples of the umbilical vein (n = 280) and artery (n = 156) from 599 healthy newborns at 37(+0)-

This study was designed to investigate the effects of substances released from non-injured and injured bovine arterial endothelial cells on 125I-low density lipoprotein uptake and degradation by smooth muscle cells in culture. It was demonstrated that endothelial cell-released non-dialysable (molecular weight cut off 12-14000) substances significantly stimulated 125I-low density lipoprotein uptake

School-aged children often experience acute respiratory symptoms. In a multicentre European study, the association between chronic respiratory symptoms (reported in a questionnaire), skin-prick test results, and lung function, and the occurrence of acute respiratory morbidity, was examined among children aged 6-12 yrs with chronic respiratory symptoms. Children with chronic respiratory symptoms, l

Using shaped laser pulses, we increase the yield of ultrafast electron injection from the sensitizer to TiO2 nanocrystals in the core part of a dye-sensitized solar cell. The temporal structure of the optimized excitation pulse is in clear correlation with nuclear oscillations in the impulsively excited dye molecule. From DFT structure optimization and normal mode analyses we identified the modes