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Aims Surgeon and patient reluctance to participate are potential significant barriers to conducting placebo-controlled trials of orthopaedic surgery. Understanding the preferences of orthopaedic surgeons and patients regarding the design of randomized placebo-controlled trials (RCT-Ps) of knee procedures can help to identify what RCT-P features will lead to the greatest participation. This informa
Objectives To determine development of new and worsening meniscal damage over 5 years after acute anterior cruciate ligament (ACL) injury comparing rehabilitation plus early ACL reconstruction (’early-ACLR’) versus rehabilitation with optional delayed ACL reconstruction (’optional-delayed-ACLR’). Methods We used knee MRIs from the only randomised controlled trial in the field including 121 young a
Knee osteoarthritis affects 40% of people during their lifetime, significantly impacting societies worldwide. Its molecular pathogenesis remains poorly understood and variable clinical phenotypes suggest it may be more than one disease. We established Synovial fluid To detect Endotypes by Unbiased Proteomics in OA (STEpUP OA) to search for molecular endotypes in knee OA synovial fluid, and to reve
This paper examines how Takituduh Bunun (Austronesian: Taiwan) encodes translocative motion, using the framework of Holistic Spatial Semantics. Based on elicited field data, we identify key lexical and grammatical resources, including motion verbs, a productive motion prefix (u-), and the locative voice. These interact flexibly to express basic semantic categories such as Path, Direction, Manner,
This paper discusses the grammatical and semantic properties ofverbalizing lexical affixes in Takituduh Bunun (Austronesian, Taiwan), arguing thatthese lexical affixes are the overt realization of the category-assigning head v, while thenominal stems of these lexical prefixes are reduced nPs, rather than full DPs. The paperdescribes the argument structure and transitivity pattern of these verbaliz
PurposeEconomic claims after surgery may be regarded as an alternative surrogate outcome for long-term deprived quality of life. This study reports economic claims of chronic pain following inguinal hernia repair.MethodsConsecutive data on economic claims following inguinal hernia repair was collected from the nationwide Danish Patient Compensation Association. Patients’ claims were stratified int
Multiple myeloma (MM) and related malignancies develop from an asymptomatic precursor condition, monoclonal gammopathy of undetermined significance (MGUS), detectable via blood testing. The benefits and harms of population-based MGUS screening remain uncertain. We conducted a nationwide screening study for monoclonal gammopathies and a randomized trial of follow-up strategies in Iceland (Iceland S
Abstract published in relation to the Nordic COnference on Forensic Medicine.
Immune tolerance induction (ITI) to eradicate an immune response against factor VIII (FVIII) has been used in hemophilia A (HA) with various success rates, costs, and treatment burden. The present study aimed to identify markers predictive of ITI success. Data were accrued from 237 patients with severe HA (FVIII level < 1%), history of persistent FVIII inhibitors ≥ 1 BU/mL and having performed ITI
Based on self-determination theory and coping research, we argue that people employ different emotion-focused coping strategies to handle threatening information about climate change, which are differently associated with the satisfaction of psychological needs and have different consequences for climate action. To test the causal effects of two emotion-focused coping strategies, we conducted a pr
