Metachromatic leukodystrophy (MLD) is a fatal, progressive neurodegenerative disorder caused by biallelic pathogenic mutations in the ARSA (Arylsulfatase A) gene. With the advent of presymptomatic diagnosis and the availability of therapies with a narrow window for intervention, it is critical to define a standardized approach to diagnosis, presymptomatic monitoring, and clinical care. To meet the

Hypomethylating agents (HMAs) are frontline therapies for Myelodysplastic Neoplasms (MDS) and Acute Myeloid Leukemia (AML). However, acquired resistance and treatment failure are commonplace. To address this, we perform a genome-wide CRISPR-Cas9 screen in a human MDS-derived cell line, MDS-L, and identify TOPORS as a loss-of-function target that synergizes with HMAs, reducing leukemic burden and i

OBJECTIVE: To examine long-term diabetes risk after preterm delivery or hypertensive disorders of pregnancy in a large population-based cohort. METHODS: This retrospective cohort study included all women with a singleton delivery in Sweden during 1973–2015 and no preexisting diabetes mellitus. Participants were followed up for development of type 2 diabetes identified from nationwide outpatient an

Background: Chronic obstructive pulmonary disease (COPD) is a severe condition affecting millions worldwide, leading to numerous annual deaths. The absence of significant symptoms in its early stages promotes high underdiagnosis rates for the affected people. Besides pulmonary function failure, another harmful problem of COPD is the systemic effects, e.g., heart failure or voice distortion. Howeve

Apicomplexan parasites move and actively enter host cells by substrate-dependent gliding motility, an unusual form of eukaryotic locomotion that differs fundamentally from the motility of prokaryotic and viral pathogens. Recent research has uncovered some of the cellular and molecular mechanisms underlying parasite motility, transmigration, and cell invasion during life cycle progression. The glid

This essay uses a microhistory of Chinese comfort women during the Asia-Pacific War to illuminate the gendered dynamics of violence and the contrasting emotions experienced by both sexually abused women and their Japanese perpetrators, forming a perpetrator-victim dyad. The essay employs the concept of intersectional emotions within a micro-historical framework to demonstrate that this violence ag

This article applies the history of emotions lens to study the emotions experienced by the ‘comfort women’ in the Japanese Empire. Emotions have been a long-neglected aspect in the study of military sexual violence. The article examines how a mélange of positive and negative emotions enabled those women to exercise some limited agency in a confined and tightly regulated space and, in some rare cas

This article explores the sociocultural history of opium consumption and its popularisation through the beauty of female attendants in Manchukuo, which was a crucial part of the Japanese Empire and an important ‘contact zone’ of diverse cultures. It offers a glimpse into the opium–prostitution nexus by exploring the legal, commercial, social, and cultural dimensions of the gendered and sexualised

This paper highlights the lives of Japanese and Korean subjects of Imperial Japan who were involved in opium production and circulation in Manchukuo. It discusses the dynamics, practices, and experiences of opium production and circulation. This paper provides a new reading of the diverse beneficiaries on the ground and of the opium industry in Manchukuo from the angles of production and circulati

Through workshops, lectures, and multidisciplinary approaches, the project 1, 2, 3 Playtime 2023–24 explored the intersections of play, games, and art. This collaboration between Inter Arts Center (IAC) and Region Skåne brought together twelve participants from various artistic disciplines and the cultural heritage sector to explore and develop game-based art as form, pedagogy, and critical reflec

Recension av Merit Hemmingsons konsert på Malmö Live

Against the backdrop of fin-de-siècle France, Hannah Halliwell presents a meticulous study of feminised visual morphine addict(ion) at the intersection of art, medicine and femininity from 1870 to 1914. The book ambitiously covers many fronts through the prism of art history, ranging across topics as diverse as art, femininity, medicine and gender. It foregrounds the forces of contemporaneous anxi

This thesis investigates the ignition and flame spread behaviour of engineered wood-based materials, focusing on Medium-Density Fibreboard (MDF), Particleboard, Oriented Strand Board (OSB), and Plywood. Thermal properties, such as thermal conductivity and specific heat capacity, were analysed using Transient Plane Source (TPS) measurements. A new technique has been introduced for measuring thermal