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Determination of allotypes G1m(f) and G1m(z) at the genomic level by subclass specific amplification of DNA and use of allele specific probes

Two oligonucleotide primers were used for selective enzymatic amplification of a DNA segment encoding a major portion of the first constant region domain (CH1) of the human IgG1 heavy chain. The selective amplification was confirmed by use of subclass-specific oligonucleotide probes. Two 15-mer oligonucleotides, hybridizing with the alleles for the allotypes G1m(f) and (z), respectively, could the

Interactions between streptococcal M proteins and human plasma proteins

Popular Abstract in Swedish Streptokocker orsakar flera olika infektioner hos människa såsom halsfluss, svinkoppor och sällsynta livshotande sjukdomstillstånd som blodförgiftning, toxiskt chock syndrom, nekrotiserande fasciit, glomerulonefrit, och reumatisk feber. För att orsaka dessa infektioner måste bakterierna undvika immun-försvaret. Komplementsystemet utgör en viktig del av det medfödda immuStreptococcus pyogenes is a common human pathogen, which causes a variety of diseases. A major virulence factor of S. pyogenes is the surface-associated M protein, which mediates resistance to phagocytosis. Several studies indicate that M proteins inhibit complement deposition and thereby phagocytosis. It is often assumed that S. pyogenes lacking M protein activates complement via the alternative

The influence of plasma insulin concentrations on tissue insulin levels in rodents: a study of the diabetic Chinese hamster and the ob/ob mouse

Immunoreactive insulin was measured in acid-ethanol extracts of kidney, brain, liver, and heart from genetically diabetic Chinese hamsters and their nondiabetic controls and from obese (ob/ob) mice and their thin littermates. Selected samples were filtered on Sephadex G-50 columns and the insulin concentration determined. There was a good correlation between the insulin level measured in the acid-

The Birth of Religion among the Balanta of Guinea-Bissau

This thesis deals with a recent event within the history of religions, the rise and development of a non-Christian prophetic movement named Kiyang-yang within the oral, kinship and ancestor based society of the Balanta in Guinea-Bissau. Kiyang-yang is headed by young women and men under the leadership of a woman prophet. The movement aims at a global and radical change of the existing Balanta way

Trilobites from the Middle and Upper Ordovician Andersön Shale Formation in Jämtland and the equivalent Killeröd Formation in Skåne, Sweden

Trilobites from the Middle and Upper Ordovician Andersön Shale Formation in Jämtland, central Sweden, and the Middle Ordovician Killeröd Formation in Skåne (Scania), southern Sweden, are revised and discussed. These formations have several genera and a few species in common, e.g. Botrioides efflorescens (Hadding, 1913a) and Pseudomegalaspis patagiata (Törnquist, 1884). The regional and vertical di

No hypoperfusion is produced in the epicardium during application of myocardial topical negative pressure in a porcine model.

ABSTRACT: BACKGROUND: Topical negative pressure (TNP), commonly used in wound therapy, has been shown to increase blood flow and stimulate angiogenesis in skeletal muscle. We have previously shown that a myocardial TNP of -50 mmHg significantly increases microvascular blood flow in the myocardium. When TPN is used in wound therapy (on skeletal and subcutaneous tissue) a zone of relative hypoperfus

Outcome and quality of life after surgically treated ankle fractures in patients over 65 years of age

Background Despite high incidence of ankle fractures in the elderly, studies evaluating outcome and impact of quality of life in this age group specifically are sparse. The aim of this study was to evaluate outcome and quality of life 6 and 12 months after injury in patients 65 years or older who had been operated on due to an ankle fracture. Methods Sixty patients 65 years or older were invited

Influence of excited state Pr3+ on the relaxation of the Pr3+-YAlO3 3H4-1D2 transition

Two-pulse photon-echo measurements on the 0.1 at. % Pr3+:YAlO3 H-3(4)-D-1(2) transition suggest that the relaxation time depends on the density of excited states created by the excitation pulses. The dependence of the relaxation time on the intensity of each excitation pulse shows that our results are inconsistent with instantaneous spectral diffusion, a model often invoked in this type of experim

Gene expression profiling of differentiating embryonic stem cells expressing dominant negative fibroblast growth factor receptor 2.

Embryonic stein (ES) cells are derived from the inner cell mass of the blastocyst and can be cultured as three-dimensional embryoid bodies (EBs) in which embryonic pregastrulation stages are faithfully mimicked. Fibroblast growth factor receptors (mainly FGFR2) are involved in the first differentiation events during early mammalian embryogenesis. It has been demonstrated that the presence of FGFR2

Effects of methyl bromide fumigation on anhydrobiotic micrometazoans

Anhydrobiotic organisms are well known for their resistance to extreme environmental conditions while in the inactive, ametabolic, state. This study confirms that this resistance also transfers to treatments with the fumigant methyl bromide. Live specimens of nematodes, rotifers, and tardigrades were found after 70 h of treatment with methyl bromide. Quantitative estimates of survival in the eutar