Sökresultat

Global loss of DNA methylation and CpG island (CGI) hypermethylation are key epigenomic aberrations in cancer. Global loss manifests itself in partially methylated domains (PMDs) which extend up to megabases. However, the distribution of PMDs within and between tumor types, and their effects on key functional genomic elements including CGIs are poorly defined. We comprehensively show that loss of

Lung cancer is a common cancer type associated with poor prognosis. Even in the group of patients with earlystage tumors, for which curative treatment is possible, lung cancer recurrence is frequent. The aim of this thesis was to investigate the potential prognostic role of mutations in tumor specimens, blood-based proteins and circulating tumor DNA.In study I, we performed EGFR mutation detection

Electronic states of a free-standing hydrogenated monolayer boron (HB) sheet were studied via soft X-ray spectroscopies at the B K-shell absorption edge and first-principles calculations. The HB sheet is semimetallic with electron and hole pockets at the Y and Γ points, respectively. The electron band results from the B-H-B bonds formed during synthesis from a MgB2 crystal, while the hole band is

Under sommaren 2018 gjordes försök med X-bandsteknik på Dalby vattentorn i Lunds kommun – ett pilotprojekt som är det svenska startskottet för användning av väderradar inom VA-området. Rapporten redovisar en litteraturstudie av tekniken. Den jämför uppmätta regndata mellan radaranläggningen och stationära regnmätare, gör en analys av flödes- och bräddmätning i avloppssystem vid några regntillfälleThe report consists of a literature study of X-band weather radar technology, a comparison of rain data between an X-band radar facility near Lund and rain gauges, an analysis of flow- and sewage overflow data during rain events and implementation ideas of the X-band radar.

this paper considers flow around arbitrarily shaped objects. The boundary conditions on the solidboundaries have been applied by replacing the boundary with a surface force distribution on the surface,such that the required boundary conditions are satisfied. The velocity on the boundary is determined byinterpolation or by local (Gaussian space) average. The source terms are determined iteratively

Large eddy simulations (LES) of a stirred reactor with a liquid volume of 0.64 m3 were performed. The tank was stirred by either two standard Rushton impellers or two Scaba 6SRGT impellers. The LES can provide details of the flow field that cannot be obtained with so‐called Reynolds‐averaged equations and the corresponding models. The unsteady spatially filtered incompressible Navier‐Stokes equati

Large eddy simulations of a baffled reactor stirred with a single Rushton turbine were performed. The turbine was positioned at mid-height in the reactor. The unsteady spatially filtered incompressible Navier–Stokes equations have been solved numerically. These large eddy simulations (LES) provide details of the flow field that cannot be obtained with the so-called Reynolds averaged equations and

One of the greatest challenges for the world today is the reduction of greenhouse gas emissions. As buildings contribute to almost a quarter of the greenhouse gas emissions worldwide, reducing the energy use of the existing building stock is an important measure for climate change mitigation. In order to increase the renovation pace, there is a need for a comprehensive technicaldocumentation that

Net Zero Energy Buildings constitute one measure to reduce energy use and increase use of energy from renewable sources. Hence, it is important share knowledge and experiences from completed projects. This case study show that it is possible to build Net Zero Energy Buildings with existing techniques. However, a common strategy to prevent or limit the build-up of ice and frost in ventilation heat

The thesis addresses a practical problem that has recently emerged on the Swedish public procurement law agenda; the fact that a considerable number of initiated tender procedures are cancelled by the contracting authority. During the last decade, the number of cancelled tenders has increased yearly and in 2017 over 13 percent of the initiated procedures governed by the EU public procurement regul

This study explores the impact an exogenous improvement in childhood health has on later-life outcomes. Using extensive and detailed register data from the Swedish Interdisciplinary Panel covering up to 2011, we follow individuals exposed to the introduction of the first vaccine against polio in Sweden (birth cohorts 1937–1966) until adulthood in order to quantify the causal effect of polio vaccin