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Radiation dosimetry of [68Ga]PSMA-11 in low-risk prostate cancer patients

Background: 68Ga-labeled Glu-NH-CO-NH-Lys(Ahx)-HBED-CC ([68Ga]PSMA-11) has been increasingly used to image prostate cancer using positron emission tomography (PET)/computed tomography (CT) both during diagnosis and treatment planning. It has been shown to be of clinical value for patients both in the primary and secondary stages of prostate cancer. The aim of this study was to determine the effect

Mucin staining is of limited value in addition to basic immunohistochemical analyses in the diagnostics of non-small cell lung cancer

Accurate diagnosis of histological type is important for therapy selection in lung cancer. Immunohistochemical (IHC) and histochemical stains are often used to complement morphology for definite diagnosis and are incorporated in the WHO classification. Our main aim was to compare different mucin stains and assess their value in relation to common IHC analyses in lung cancer diagnostics. Using tiss

Tracing the climate signal : mitigation of anthropogenic methane emissions can outweigh a large Arctic natural emission increase

Natural methane emissions are noticeably influenced by warming of cold arctic ecosystems and permafrost. An evaluation specifically of Arctic natural methane emissions in relation to our ability to mitigate anthropogenic methane emissions is needed. Here we use empirical scenarios of increases in natural emissions together with maximum technically feasible reductions in anthropogenic emissions to

Brain responses to morphologically complex verbs : An electrophysiological study of Swedish regular and irregular past tense forms

The present electrophysiological study investigated irregular versus regular verb form processing in Swedish during reading. In line with previous results from other languages, overregularized verbs, i.e. incorrect irregular stem + regular past tense suffix combinations (e.g. *stjäl + de ‘steal + past tense’), elicited a left-lateralized negativity (LAN) relative to correct irregulars (stal ‘stole

Nutritional status of children with intestinal parasites from a tropical area of Bolivia, emphasis on zinc and iron status

Malnutrition and parasitic diseases are within the major issues in rural areas in developing countries. In this study, the nutritional status, dietary intake including mineral absorption inhibitor (phytate), hematological indicators and trace element status (zinc, iron) were evaluated and associated to the presence of intestinal parasites in a group of children from a rural area of Bolivia. The re

Yet another kinetic mechanism for hydrogen combustion

Recent suggestion by Burke and Klippenstein (2017) that chemically termolecular reactions H + O2 + R may significantly affect kinetic pathways under common combustion situations requires careful analysis, since, if included in contemporary kinetic mechanisms, these reactions affect global reactivity and calculated burning velocities of laminar premixed flames. In the view of their impact, a detail

Respiratory tract deposition of inhaled roadside ultrafine refractory particles in a polluted megacity of South-East Asia

Recent studies demonstrate that Black Carbon (BC) pollution in economically developing megacities remain higher than the values, which the World Health Organization considers to be safe. Despite the scientific evidence of the degrees of BC exposure, there is still a lack of understanding on how the severe levels of BC pollution affect human health in these regions. We consider information on the r

Industrial Symbiosis : towards a design process for eco-industrial clusters by integrating Circular Economy and Industrial Ecology perspectives

Industrial Symbiosis (IS) is a collective approach to competitive advantage in which separate industries create a cooperative network to exchange materials, energy, water and/or by-products. By addressing issues related to resource depletion, waste management and pollution, IS plays an important role in the transition towards sustainable development. In the literature, two conceptual perspectives

The association of self-reported discrimination to all-cause mortality : A population-based prospective cohort study

Discrimination has is an important social determinant of health and though some research has been carried out on this it is mostly from the United States, which may not be generalisable to Europe and Sweden. This study investigated the association between self-reported experiences of repeated discrimination and all-cause mortality in Scania, Sweden. The Scania Public Health survey was sent out in

Microbial growth and carbon use efficiency in soil : Links to fungal-bacterial dominance, SOC-quality and stoichiometry

Microbial decomposers are responsible for the breakdown of organic matter (OM) and thus regulate soil carbon (C) stocks. During the decomposition of OM, microorganisms can use the assimilated C for biomass production or respire it as CO2, and the fraction of growth to total assimilation defines the microbial carbon-use efficiency (CUE). As such, CUE has direct consequences for how microbial decomp

Hybrid manufacturing accounting in mixed process environments : A methodology and a case study

When manufacturing firms are deciding which products to produce, it is of utmost importance that they correctly allocate costs to products. It is common practice for manufacturers to use a single model for cost allocation and management accounting and to apply it to all products and production resources. Since most organisations have different types of production processes within their operations,

Sustainability criteria for assessing nanotechnology applicability in industrial wastewater treatment : Current status and future outlook

Application of engineered nanomaterials for the treatment of industrial effluents and to deal with recalcitrant pollutants has been noticeably promoted in recent years. Laboratory, pilot and full-scale studies emphasize the potential of this technology to offer promising treatment options to meet the future needs for clean water resources and to comply with stringent environmental regulations. The

Univariate and classification analysis reveals potential diagnostic biomarkers for early stage ovarian cancer Type 1 and Type 2

Biomarkers for early detection of ovarian tumors are urgently needed. Tumors of the ovary grow within cysts and most are benign. Surgical sampling is the only way to ensure accurate diagnosis, but often leads to morbidity and loss of female hormones. The present study explored the deep proteome in well-defined sets of ovarian tumors, FIGO stage I, Type 1 (low-grade serous, mucinous, endometrioid;

The Fe (III)/Fe(II) redox couple as a probe of immobilized tobacco peroxidase : Effect of the immobilization protocol

Non-turnover voltammetry is a sensitive tool to characterize the electrochemical properties of redox proteins. However, the catalytically competent oxidation states of most peroxidases do not display the required electrochemical reversibility. In this report, we circumvent this limitation and exploit the voltammetric response associated with the Fe(III)/Fe(II) redox couple of tobacco peroxidase to

Midregional proadrenomedullin predicts reduced blood pressure and glucose elevation over time despite enhanced progression of obesity markers

OBJECTIVES: Elevated plasma levels of the vasodilating hormone adrenomedullin (ADM) predict cardiovascular disease and have been associated with hypertension and obesity. We aimed to examine the independent relationship between ADM and the progression of major cardiometabolic risk factors during long-term follow-up. METHODS: We studied midregional pro-ADM (MR-proADM) in fasting plasma in 3298 part

Silver nano-needles : Focused optical field induced solution synthesis and application in remote-excitation nanofocusing SERS

Tapered metallic nanostructures that harbor surface plasmons are highly interesting for nanophotonic applications because of their waveguiding and field-focusing properties. Here, we developed a focused optical field induced solution synthesis for unique crystallized silver nano-needles. Under the focused laser spot, inhomogeneous Ag monomer concentration is created, which triggers the uniaxial gr

Instantaneous one-dimensional equivalence ratio measurements in methane/air mixtures using femtosecond laser-induced plasma spectroscopy

Equivalence ratio is one of the most significant parameters in combustion flow fields. In this paper, femtosecond laser-induced plasma spectroscopy (FLIPS) technique for instantaneous one-dimensional local equivalence ratio measurements were performed. By measuring the spatially resolved spectra of FLIPS, we found that the spectral peak area ratios of CH (431 nm)/N2 (337 nm), CH (431 nm)/N2 (357 n

Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development

Midbrain dopamine (mDA) neurons constitute a heterogenous group of cells that have been intensely studied, not least because their degeneration causes major symptoms in Parkinson's disease. Understanding the diversity of mDA neurons - previously well characterized anatomically - requires a systematic molecular classification at the genome-wide gene expression level. Here, we use single cell RNA se