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The childhood tumour neuroblastoma is derived from immature cells of the sympathetic nervous system, which have become arrested at different maturation stages. Neuroblastoma is a malignancy with a high degree of heterogeneity, and there is a correlation between a poor differentiation status and a more aggressive phenotype. The MYCN gene is amplified in approximately 25% of neuroblastoma tumours an
Abstract is not available
Fragility fractures are correlated to reduced bone size and/or reduced volumetric bone density (vBMD). These region-specific deficits may originate from reduced mineral accrual and/or reduced skeletal growth during the first 2 decades of life. Before pathological development can be defined, normal skeletal growth must be described. To evaluate growth of bone size, accrual of bone mineral content (
Popular Abstract in Swedish Sedan Sverige för ungefär tio år sedan blev medlem av Europeiska unionen, änd-rades svensk arbetsrätt så att arbetstagare i vissa fall har en rätt att välja att följa med en verksamhet som övergår till en ny arbetsgivare. Något nytt anställningsavtal skall inte anses ha träffats. De arbetstagare som berörs av verksamhetsövergången har dessutom ett skydd mot att bli uppsWhen Sweden in 1995 became a member of the European Union, Swedish labour legislation was enacted on the safeguarding of employees’ rights in the event of transfer of undertaking. These Swedish rules and regulations are examined. EU law and national law form two parallel systems, which between themselves arrange the legal sources hierarchically, and, as a result of that, the Member States have tra
The article treats the problem why a descriptive grammar cannot avoid from being normative in some ways. some uses of language are always excluded. on the other hand a descriptive grammar should account for competing variants where there might be disagreement among the language users which expression is correct, i.e. should be accepted as norm. The descriptive grammar does not tell which variant i
The effect of long-term ethanol exposure on muscarinic receptors was investigated in human neuroblastoma SH-SY5Y cells. Exposure to 100 mM ethanol for 4 days enhanced both peak and steady-state levels of carbachol-stimulated inositol 1,4,5-bisphosphate increase. An ethanol concentration of 50 mM was sufficient for an enhancement of this event. The carbachol-stimulated decrease in [3H]inositol-labe
Background: Factors related to the metabolic syndrome and low levels of vitamin D have been implicated as risk factors for prostate cancer. Insofar, no studies have assessed their joint effects on prostate cancer risk. Methods: We studied (a) the associations of vitamin D with the metabolic syndrome factors body mass index, systolic and diastolic blood pressure, and high-density lipoprotein choles
The present work reports on spectral transmission and scattering dependencies, the status of scattered light polarization for PLZT ceramics elements working in the electrically induced longitudinal light scattering mode. Experiments are done with the double optical integrated sphere technique. Several devices using the electrically controlled scattering effect are developed - eye occluders for stu
The majority of tumors from patients affected by hereditary nonpolyposis colorectal cancer (HNPCC) exhibit a mutator phenotype characterized by widespread microsatellite instability (MSI) and somatic mutations in repeated sequences in several cancer-associated genes. An inverse relationship between MSI and chromosomal instability (CIN) has been demonstrated and HNPCC-associated tumors are generall
Aims: To determine whether albuminuria, hypertension, or HbA(1c) are independently associated with antipericyte autoantibodies (APAAs) in type 2 diabetes mellitus. Methods: Two hundred ninety-nine subjects with different degrees of retinopathy according to the Early Treatment Diabetic Retinopathy Study Scale participated in this study. Albuminuria was defined as an albumin/creatinine ratio above t
