Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain

Despite the initial promise of immunotherapy for CNS disease, multiple recent clinical trials have failed. This may be due in part to characteristically low penetration of antibodies to cerebrospinal fluid (CSF) and brain parenchyma, resulting in poor target engagement. We here utilized transcranial macroscopic imaging to noninvasively evaluate in vivo delivery pathways of CSF fluorescent tracers.

Senior people’s reasoning and prioritizing of research on home and health in old age

Introduction to multi-jet final states and energy flows

Usability testing of an android app that identifies accessible housing environments

Fall-related activity avoidance in people ageing with Parkinson’s disease

The SM and NLO Multileg and SM MC Working Groups: Summary Report

THEPEG: Toolkit for High Energy Physics event generation

Diffractive and elastic scattering in the dipole model

CEDAR: Progress and status report

What HERA may provide?

Extreme Ultraviolet Beam Enhancement by Relativistic Surface Plasmons

The emission of high-order harmonics in the extreme ultraviolet range from the interaction of a short, intense laser pulse with a grating target is investigated experimentally. When resonantly exciting a surface plasmon, both the intensity and the highest order observed for the harmonic emission along the grating surface increase with respect to a flat target. Harmonics are obtained when a suitabl

Monte Carlo generators

I discuss some recent development of Monte Carlo event generators and point out some problems. Starting with the issue of combining matrix element generators and parton shower algorithms, I will continue with discussing the problems associated with describing small-x final states and discuss some recent model developments for describing multiple partonic scatterings and underlying events in hadron

Extensive study of electron acceleration by relativistic surface plasmons

The excitation of surface plasmons with ultra-intense (I ∼ 5 × 1019 W/cm2), high contrast (∼1012) laser pulses on periodically modulated solid targets has been recently demonstrated to produce collimated bunches of energetic electrons along the target surface [Fedeli et al., Phys. Rev. Lett. 116, 015001 (2016)]. Here, we report an extensive experimental and numerical study aimed to a complete char

The QCD / SM working group: Summary report

User-driven housing for older people

Matching the dipole cascade model with fixed order matrix elements

Biodiversity loss through speciation collapse : Mechanisms, warning signals, and possible rescue

Speciation is the process that generates biodiversity, but recent empirical findings show that it can also fail, leading to the collapse of two incipient species into one. Here, we elucidate the mechanisms behind speciation collapse using a stochastic individual-based model with explicit genetics. We investigate the impact of two types of environmental disturbance: deteriorated visual conditions,

TESLA: The superconducting electron positron linear collider with an integrated X-ray laser laboratory. Technical design report. Pt. 6: Appendices. Chapter 2: THERA: Electron proton scattering at s**(1/2) approximately 1-TeV

Hard color singlet exchange at the Tevatron

What is the experimental evidence for the BFKL pomeron?