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Background: Many patients with aggressive B-cell lymphomas and high clinical risk score still die of lymphoma after conventional R-CHOP chemoimmunotherapy. We hypothesized that intensified chemoimmunotherapy including systemic central nervous system (CNS) prophylaxis improves outcome and reduces the incidence of CNS-related events. Patients and methods: Inclusion criteria were age 18-65 years, pri

Hidden Markov models (HMMs) are probabilistic functions of finite Markov chains, or, put in other words, state space models with finite state space. In this paper, we examine subspace estimation methods for HMMs whose output lies a finite set as well. In particular, we study the geometric structure arising from the nonminimality of the linear state space representation of HMMs, and consistency of

Rheumatoid arthritis (RA) and multiple sclerosis (MS) are complex inflammatory autoimmune diseases. The aetiology is largely unknown but the risk of developing disease is dependent on both genetic and environmental factors. Extensive efforts have been done to identify the underlying genes in order to understand the molecular mechanisms of the diseases. Until recently, only a few genes have been qu

Objective Examine the relationship between antibodies to 25 oral bacteria and pancreatic cancer risk in a prospective cohort study. Design We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study. Analyses were conducted using conditional logi

A set of single pass full penetration friction stir bead-on-plate and butt welds in HSLA-65 steel were produced using a range of traverse speeds (50 to 500 mm/min) and two tool materials (W-Re and PCBN). Part I described the influence of process and tool parameters on the microstructure in the weld region. This article focuses on the influence of these parameters on residual stress, but the presen

AimSpecies are responding to climate change by changing their distributions, creating debate about the effectiveness of existing networks of protected areas. As a contribution to this debate, we assess whether regional winter abundances and distribution of the Smew Mergellus albellus, a migratory waterbird species listed on Annex I (EU Birds Directive) that overwinters exclusively in European wetl

Focusing clinical investigations on outcomes that are meaningful from an end-user perspective is central in clinical research, particularly in chronic disorders such as Parkinson's disease (PD). However, little is known about how end-users such as people with PD (PwPD) and health care professionals (HCPs) view and prioritize therapeutic outcomes. To compare the perspectives of PwPD and HCPs regard

Polymer-particle interactions can cause particle flocculation and phase separation problems in waterborne coatings. The problems can be the result of interactions that are either too weak or too strong. It is known by empirical work that addition of surfactants can minimize these problems. In this study, the authors have investigated how different types of surfactants influence the polymer-particl

During flow testing of a deep, 1927-m, gravel packed screen completed well, it became apparent that well development was needed to increase productivity. A hydrojetting system using coiled tubing in combination with simultaneous pumping was developed and tested and found to be successful. To verify whether the jetting improved the well, the results of a pumping test conducted before and after the

Altered secretion of insulin as well as glucagon has been implicated in the pathogenesis of Type 2 diabetes (T2D), but the mechanisms controlling glucagon secretion from alpha-cells largely remain unresolved. Therefore, we studied the regulation of glucagon secretion from alpha TC1-6 (alpha TC1 clone 6) cells and compared it with insulin release from INS-1 832/13 cells. We found that INS-1 832/13

The crystal structures of the binary cadmium-rich complex metal alloys NiCd6+delta (-0.32 <= delta <= 0.35) and NiCd1+delta (0 <= d <= 0.05) were studied by means of single crystal X-ray diffraction. The partitioning of the NiCd6+delta structure into clusters grouped around all 16 high symmetry points of the face centered cubic cell leads to the identification of two partial structures forming rep

The article offers a new approach for the exploration of media and television studies by extracting the television-philosophy implicit in Samuel Beckett’s television play …but the clouds…. The reading focuses on the immanent logic of the play seen as a televisual and an intermedial whole, instead of constructing it as an intertextual tapestry of references. The article argues against a popular int

The ECL cells constitute the major endocrine cell population in the acid-producing part of the stomach. Gastrin from G cells in the antrum is the main stimulus of gastric acid secretion. Gastrin stimulates the ECL cells in the oxyntic mucosa to mobilize histamine, which in turn stimulates the parietal cells to produce hydrochloric acid. In the present study we assessed the usefulness and limitatio

The question whether temperate marine fishes typically consist of self-sustaining populations or "open" populations still remains unresolved. At the heart of this population connectivity problem lays the nature of the stock separation mechanisms. Fish populations could be segregated either by environmental forcing, accompanied with opportunistic recruitment of juveniles to spawning areas, or by ph

The high-pressure structural behavior of the binary intermetallic compounds CoSn, FeSn, and NiIn with the peculiar void containing CoSn (B35)-type structure has been studied by means of room-temperature diamond anvil cell and high-temperature multianvil experiments, as well as by first-principles calculations. All three compounds remain structurally stable at pressures up to at least 25 GPa, where

Recent studies suggest that service definition is an ongoing process, with service characteristics being temporarily stabilised and destabilised through buyer–service provider interactions. However, little is still known about how and, in particular, why services are (re)defined during the sourcing process, e.g., in terms of their intended outputs, how they are performed (processes), the inputs re