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Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease

BACKGROUND: Respiratory tract deposition of airborne particles is a key link to understand their health impact. Experimental data are limited for vulnerable groups such as individuals with respiratory diseases. The aim of this study is to investigate the differences in lung deposition of nanoparticles in the distal lung for healthy subjects and subjects with respiratory disease.METHODS: Lung depos

Historical trends in calls to action : Climate change, pro-environmental behaviours and green social work

Social works’ relationship with the environment and the role of social workers in addressing environmental issues under climate change are usually neglected in mainstream practice. I begin this chapter by discussing the importance of social work as a field of research and practice that needs to actively carve out a position of expertise and engagement with emerging environmental issues at the micr

Classical-to-quantum crossover in electron on-demand emission

Emergence of a classical particle trajectory concept from the full quantum description is a key feature of quantum mechanics. Recent progress of solid-state on-demand sources has brought single-electron manipulation into the quantum regime; however, the quantum-to-classical crossover remains unprobed. Here we describe theoretically a mechanism for generating single-electron wave packets by tunneli

Selective targeting of primary and secondary nucleation pathways in Ab42 aggregation using a rational antibody scanning method

Antibodies targeting Ab42 are under intense scrutiny because of their therapeutic potential for Alzheimer’s disease. To enable systematic searches, we present an “antibody scanning” strategy for the generation of a panel of antibodies against Ab42. Each antibody in the panel is rationally designed to target a specific linear epitope, with the selected epitopes scanning the Ab42 sequence. By screen

Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification

Parkinson's disease (PD) is characterized by proteinaceous aggregates named Lewy Bodies and Lewy Neurites containing α-synuclein fibrils. The underlying aggregation mechanism of this protein is dominated by a secondary process at mildly acidic pH, as in endosomes and other organelles. This effect manifests as a strong acceleration of the aggregation in the presence of seeds and a weak dependence o

En ny social bostadspolitik? Nej, men en bra början.

S-rapporten, ”en ny social bostadspolitik” levererar en bra problemanalys och flera goda målbeskrivningar men deras förslag orkar inte helt i mål, menar Ingemar Bengtsson, Universitetslektor vid Avdelningen för Fastighetsvetenskap, Lunds Universitet. Ingemar Bengtsson ifrågasätter gruppens allmänna strävan att samhället ska öka den samlade bostadskonsumtionen och efterlyser i följande kommentar me

Den eleganta cyklisten : Cykling, mode och kvinnlighet i sekelskiftets svenska och danska damtidningar

The elegant cyclist: Cycling, fashion and femininity in Swedish and Danish women’s magazines at the turn of the 20th century.At the turn of the 20th century the new sport of cycling was endowed with femininity in Scandinavian ladies’ magazines. An analysis of the magazines Idun, Svensk Damtidning, Damernes Blad and Hjemmet between 1890 and the 1910s show that both Swedish and Danish magazines appe

The Inverted Relationship : Constitutive Theory of Law and the Enforcement of Orthodoxy in Book XVI of the Theodosian Code

This paper focuses on the question if, and if so how, the Theodosian Code, the first legal codification of the Roman Empire and its devoted to religion Book XVI, facilitated the formation and enforcement of the concept of orthodoxy and its boundaries. It uses the propositions of the Cognitive Science of Religion to advance a new understanding of the shift towards orthodoxy, as the process in which

Montelukast, a CysLT1 receptor antagonist, reduces colon cancer stemness and tumor burden in a mouse xenograft model of human colon cancer

Inflammation is implicated in the etiology of sporadic colon cancer (CC), which is one of the leading causes of cancer-related deaths worldwide. Here, we report that inhibition of the inflammatory receptor CysLT1 through its antagonist, montelukast, is beneficial in minimizing stemness in CC and thereby minimizing tumor growth in a mouse xenograft model of human colon cancer. Upon treatment with m