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The carcinogenicity of cigar and pipe smoking is established but the effect of detailed smoking characteristics is less well defined. We examined the effects on cancer incidence of exclusive cigar and pipe smoking, and in combination with cigarettes, among 102,395 men from Denmark, Germany, Spain, Sweden and the United Kingdom in the EPIC cohort. Hazard ratios (HR) and their 95% confidence interva

Background. Second-generation immigrants have an increased risk of schizophrenia, a finding that still lacks a satisfactory explanation. Various operational definitions of second-generation immigrants have been used, including foreign parental country of birth. However, with increasing global migration, it is not clear that parental country of birth necessarily is informative with regard to ethnic

Dinoflagellates belonging to the genus Gambierdiscus are the causative agent of ciguatera fish poisoning (CFP). This syndrome, which is widespread in tropical and subtropical regions, has recently been reported also in temperate latitudes. Taxonomic studies of Gambierdiscus have yet to completely couple the morphological features of member species with their genetics. In this study, the cellular a

The Muhammad cartoon crisis in 2005 provides an illustrative example of how crises travel across geographical boundaries, in this case, from a national newspaper into a full-fledged public diplomacy crisis at the international level. From a crisis management perspective, a multilevel setting poses a real challenge to actors trying to contain the situation at hand. Likewise, the multilevel nature o

We studied the solubilization of oil in the C16E8/hexadecane/H2O system. Close to the phase inversion temperature (PIT), the system, at equilibrium, can form either homogeneous states (i.e., microemulsions) at high surfactant concentrations or three-phase states at lower concentrations. We show that, under gentle shear, at a line we named the clearing boundary (CB), located a few degrees below the

Elevated levels of tropospheric ozone can significantly impair the growth of crops. The reduced removal of CO2 by plants leads to higher atmospheric concentrations of CO2, enhancing radiative forcing. Ozone effects on economic yield, e. g. the grain yield of wheat (Triticum aestivum L.), are currently used to model effects on radiative forcing. However, changes in grain yield do not necessarily re

Antibody-mediated blockade of CTLA4 has been shown to be effective in treating a select group of patients with late-stage melanoma. The precise mechanism underlying the clinical activity of CTLA4 immunotherapy is poorly understood, although recent experimental findings indicate that antibody-mediated depletion of regulatory T cells (Tregs) in the tumor microenvironment plays a key role in efficaci

The turbidity variation in time and space is investigated in the downstream stretch of the river Gota Alv in Sweden. The river is heavily regulated and carries the discharge from the largest fresh water lake in Sweden, Lake Vanern, to the outflow point in Goteborg Harbour on the Swedish west coast. The river is an important waterway and serves as a fresh-water supply for 700 000 users. Turbidity i

There are inconsistent and limited data available to assess the relationship between fat intake and risk of epithelial ovarian cancer (EOC). We examined the consumption of total fat, fat sources and fat subtypes in relation to risk of EOC and its major histologic subtypes in the European Prospective Investigation into Cancer and Nutrition which includes incident invasive (n=1095) and borderline (n

Despite recent progress, prognosis for the elderly (defined as aged 70 or more) afflicted by Traumatic Brain Injury (TBI) is unfavorable and surgical intervention remains controversial. Research during the last decade on the mortality rates or prognostic factors for survival in the elderly is limited.

Modern large-scale software development is a complex undertaking and coordinating various processes is crucial to achieve efficiency. The alignment between requirements and test activities is one important aspect. Production and maintenance of software result in an ever-increasing amount of information. To be able to work efficiently under such circumstances, navigation in all available data needs

Socially anxious individuals tend to underestimate their performance largely due to attentional bias. Video and audio feedback (AF) with cognitive preparation (CP) have shown to improve socially anxious individuals' evaluation of their performance in previous studies. In the present study, it was hypothesized that one of the three steps in CP, reduced self-focus (RS), is sufficient to cause an imp

This article presents the possibilities and advantages of integrating social psychology and political science in the study of intergroup relations in diverse societies in Western Europe. Social psychology provides interesting insights in understanding the emotional and cognitive consequences of increased diversity. However, this literature tends to overlook the role of institutional discourses and

Arctic sea ice represents an important component of the climate system, and the present reduction of sea ice in the Arctic is of major concern. Despite its importance, little is known about past changes in sea-ice cover and the underlying forcing mechanisms. Here, we use diatom assemblages from a marine sediment core collected from the West Greenland shelf to reconstruct changes in sea-ice cover o

The transcription factor interferon regulatory factor-8 (IRF8) is highly expressed in myeloid progenitors, while most myeloid leukemias show low or absent expression. Loss of IRF8 in mice leads to a myeloproliferative disorder, indicating a tumor-suppressive role of IRF8. The Wilms tumor gene 1 (WT1) protein represses the IRF8-promoter. The zinc finger protein ZNF224 can act as a transcriptional c

We present a high resolution, multiproxy study of the relationship between pelagic and benthic environments of a coastal upwelling system in the subtropical NE Atlantic Ocean. Marine sediments corresponding to late MIS3 to the Holocene in the radiocarbon dated core GeoB7926, retrieved off Mauritania (21 degrees N) were analysed to reconstruct productivity in surface waters and its linkage to deep

Palaeomagnetic and geochronological studies on mafic rocks in the Lake Ladoga region in South Russian Karelia provide a new, reliably dated Mesoproterozoic key paleopole for the East European Craton (Baltica). U-Pb dating on baddeleyite gives a crystallisation age of 1452 +/- 12 Ma for one of the studied dolerite dykes. A mean palaeomagnetic pole for the Mesoproterozoic dolerite dykes. Valaam sill

Out of the 14 agnostoid species/subspecies so far recorded from the Furongian of Scandinavia, seven are excellent biostratigraphical indices and important for correlation between Baltica and other palaeocontinents. Glyptagnostus reticulatus, Aspidagnostus lunulosus and Agnostus (Homagnostus) obesus first appear at the base of the G. reticulatus Zone, allowing a precise correlation of the base of t

We address the dispersion properties of overdamped Brownian particles migrating in a two-dimensional acoustophoretic microchannel, where a pressure-driven axial Stokes flow coexists with a transverse acoustophoretic potential. Depending on the number and symmetries of the stable nodal points of the acoustophoretic force with respect to the axial velocity profile, different convection-enhanced disp