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Background: T1D and AITD are autoimmune disorders commonly occurring in the same family and even in the same individual. The genetic contribution to these disorders is complex making uncovering of susceptibility genes very challenging. The general aim of this study was to identify loci and genes contributing to T1D/AITD susceptibility. Our strategy was to perform linkage and association studies in

Mutation rates for X-linked recessive diseases have so far been estimated indirectly by postulating an equilibrium between the loss of defective genes caused by the low reproductive fitness of affected males and the gain resulting from new mutations. Here, for the first time, we directly estimate both the overall and sex-specific mutation rates for haemophilia B by detecting the gene defect of the

BACKGROUND CONTEXT: Proper patient selection is of outmost importance in surgical treatment of degenerative disc disease (DDD) with chronic low back pain (CLBP). Among other factors gender was previously found to influence lumbar fusion surgery outcome.PURPOSE: This study investigates whether gender affects clinical outcome after lumbar fusion.STUDY DESIGN: National registry cohort study PATIENT S

BACKGROUND: Severe obesity in adolescence is associated with reduced life expectancy and impaired quality of life. Long-term benefits of conservative treatments in adolescents are known to be modest, whereas short-term outcomes of adolescent bariatric surgery are promising. We aimed to compare 5-year outcomes of adolescent surgical patients after Roux-en-Y gastric bypass with those of conservative

Background: Antisocial personality and psychopathic traits have constantly been found to accompany criminal and aggressive behaviors, but little attention has been given to aspects of character maturity and its relation to such behaviors. The present study investigated (1) whether level of character maturity (low, medium, and high) is associated with amount of aggressive antisocial behaviors (AABs

This paper investigates how Additive Manufacturing (AM) technologies, as a process innovation, may contribute to a job creation. Further, the various mechanisms in which AM may contribute to an increase in job creation as well as the types of jobs are analyzed. The analysis also goes beyond AM technologies and incorporates other non-technological factors which foster job creation, i.e. higher wage

ackground: The separate spheres, in which men dominate the public sphere of politics, arts, media, and wage work and women dominate the private sphere of unpaid production and caring, is a powerful configuration in much social theory (including Parsons, Becker, and Goode), which posited that with industrialization, family structures and activities would converge towards the nuclear family with strBackground: The separate spheres, in which men dominate the public sphere of politics, arts, media, and wage work and women dominate the private sphere of unpaid production and caring, is a powerful configuration in much social theory (including Parsons, Becker, and Goode), which posited that with industrialization, family structures and activities would converge towards the nuclear family with st

Background: Resilience has been shown to be protective against alcohol use disorders (AUDs), but the magnitude and nature of the relationship between these 2 phenotypes are not clear. The aim of this study was to examine the strength of this relationship and the degree to which it results from common genetic or common environmental influences. Methods: Resilience was assessed on a 9-point scale du

Heavy combined lung weight at autopsy is a non-specific autopsy finding associated with certain causes of death such as intoxication. There is however no clear definition of what constitutes "heavy" lung weight. Different reference values have been suggested but previous studies have been limited by small select populations and only univariate regression has been attempted. The aim of this study w

This paper focuses on the on-going doctoral research of the writer. Specifically, the topic of this article is on the methodology, the theoretical approach and the first steps of the research. The general aim is the contribution of 3D documentation and the 3D digital approach to the stylistic and typological study of archaeological collections. The study is applied to the collection of the Ayia Ir

It is commonly believed that the academic sector does not generate enough value for society. This value is often measured in terms of new firms, patents and products, leading to policy responses which aim to enhance ‘commercialisation’ by academics. However, others maintain that academic research generates benefits in many ways, some of which are difficult to measure, and that policy must look bey