Background: Near-infrared spectroscopy (NIRS) and intravascular ultrasound are promising imaging modalities to identify non-obstructive plaques likely to cause coronary-related events. We aimed to assess whether combined NIRS and intravascular ultrasound can identify high-risk plaques and patients that are at risk for future major adverse cardiac events (MACEs). Methods: PROSPECT II is an investig

I Sverige är bevisvärderingen fri, vilket innebär att den inte är bunden av legala regler. Vid bevisvärderingen använder sig domaren av vad lagstiftaren benämner allmänna erfarenhetssatser, som möjliggör att bevisningen kan sättas i en kontext. Erfarenhetssatser utgör en generalisering beträffande hur omständigheter vanligtvis förhåller sig till varandra och baseras på allmän bildning och livserfa

In their quest for a more efficient and effective utilization of the resources allocated to engineering design projects, and thus to the overall product development project from which the current design task(s) originate, an increasing number of companies allow engineering designers to perform Computer-Based Design Analysis (CBDA) on their own – CBDA is here confined to quantitative analyses using

AbstractCystic fibrosis (CF) is caused by mutations in the anion channel and protein regulator CFTR. The most common co-morbidity in CF is CF-related diabetes (CFRD) affecting ~50% of adult patients. The etiopathology of CFRD is largely unknown but the destruction of the exocrine pancreas is thought to contribute. However, the hypothesis that CFTR has a direct role in the endocrine pancreas has no

Bergskedjor är uppbyggda av olika slags berggrund som skjutits samman i de zoner på Jorden där tektoniska plattor möts (konvergerar). Sådana processer sker i dag exempelvis i Himalaya, Alperna eller Anderna, men det finns också gamla, nu inaktiva, bergskedjor som de Skandinaviska Kaledoniderna (ca 400 miljoner år gammal) eller den Svekonorvegiska bergskedjan (ca 1000 miljoner år gammal, i sydvästr

Information and communication are increasingly being conveyed over the Internet. The forms of service and commerce that we are familiar with today will most likely be reduced in scale in the future to be replaced by new electronic solutions. For this reason, it is important that new technology be designed so that as many people as possible can utilize it. Accessibility to a range of services and i

The study makes an inventory of learning opportunities young people were offered in connection with CEI 2016, one of the annual international conferences organized by the NGO named Caretakers of the Environment International (CEI), which year 2016 took place in Aalborg in Denmark. The learning opportunities offered by this transnational learning community are discussed in relation to some essentia

IMPORTANCE The positron emission tomography (PET) tracer [18F]flortaucipir allows in vivo quantification of paired helical filament tau, a core neuropathological feature of Alzheimer disease (AD), but its diagnostic utility is unclear. OBJECTIVE To examine the discriminative accuracy of [18F]flortaucipir for AD vs non-AD neurodegenerative disorders. DESIGN, SETTING, AND PARTICIPANTS In this cross-

Artificial outdoor lighting for pedestrians should provide for a safe and secure outdoor environment after dark. Pedestrian lighting thereby has implications for active transportation and sustainable mobility. Installations of new energy efficient lighting applications should be evaluated in terms of pedestrian’s perception, evaluation and behaviour in the lit environment. Today there is a lack of

Endocrine disorders that lead to a state of chronic high blood glucose levels are collectively referred to as diabetes. This metabolic disease is mainly categorized into type 1 (T1D) and type 2 diabetes (T2D). These diabetic forms originate from distinct triggering environmental, genetic, and altered mechanisms. T2D is a consequence of metabolic load, peripheral insulin resistance, and failure of

Incretin-based therapy is associated with low risk of hypoglycemia in type 2 diabetes mellitus (T2DM) possibly due to its glucose-dependency in stimulating insulin secretion and a sustained glucagon response during hypoglycemia. This is of special relevance when it is combined with insulin or given to elderly patients since both insulin therapy and high age are associated with impaired glucagon co

For several decades, a whole range of critical approaches emphasizing networks, flows and mobility have gained ground in social theory and slowly made its way into governmental practice. In few fields of study has the epistemological shift been as marked in both theory and practice as urban studies in general, and those interested in public space in particular. From Jane Jacobs ‘ballet’ of the str

Background: The relationship between dyslipidemia, inflammation and CV organ damage in type 2 diabetes mellitus (T2DM) is complex. Insulin resistance and inflammatory cytokines interleukins (ILs) increase plasma triglycerides (TG). ILs also up-regulate expression of matrix-metalloproteinases (MMPs) that, together with TG, decrease high density lipoprotein cholesterol (HDL) levels. High TG, low HDL

It has been long known that hyperglycaemia-induced β-cell dysfunction precipitates type 2 diabetes (T2D) in insulin-resistant obesity, although the underlying mechanisms are still poorly defined. The few frequently used antidiabetic drugs on the market have still not satisfactorily demonstrated any long-lasting improvements of β-cell function and prevention of the disease. Islets synthesise and se

Lung cancer is a common cancer type associated with poor prognosis. Even in the group of patients with earlystage tumors, for which curative treatment is possible, lung cancer recurrence is frequent. The aim of this thesis was to investigate the potential prognostic role of mutations in tumor specimens, blood-based proteins and circulating tumor DNA.In study I, we performed EGFR mutation detection

Plants like all other eukaryotic organisms carry most of their DNA in the nucleus. In addition, plants also have both chloroplasts and mitochondria that contain their own genetic material. The genomes in chloroplasts and mitochondria control certain vital processes, but most often the organelles act under strict nuclear control. Usually the nuclear and organellar genomes live in "harmony", promoti