Sökresultat

Background: Epidemiological evidence on weight change and atrial fibrillation (AF) remains limited and inconsistent. Previous studies on body mass index (BMI) in youth and AF rarely considered subsequent BMI. This study aimed to assess the associations of AF with weight change and BMI in youth, as well as modified effect by genetic susceptibility of AF. Methods: The study included 21,761 individua

Importance: Electroconvulsive therapy (ECT), wherein a generalized epileptic seizure is induced, is a treatment for major depressive disorder (MDD). Currently, it is unclear whether there is an association between seizure length and treatment outcome. Objective: To explore the association between seizure duration, potential confounding variables, and ECT treatment outcome. Design, Setting, and Par

Background: The quality of the total mesorectal excision specimen in rectal cancer surgery is assessed with a three-tier grade (mesorectal, intramesorectal and muscularis propria). This study aimed to analyse the prognostic impact of the total mesorectal excision grade on survival, and to identify risk factors for intramesorectal and muscularis propria resection in a population-based setting. Meth

AIMS: Biomarkers associated with asymptomatic ventricular dysfunction might improve risk stratification and identify pathways leading to heart failure (HF). We explored the association between proteomic biomarkers and left ventricular hypertrophy (LVH), diastolic dysfunction (DD) and incident HF in three population-based cohorts.METHODS AND RESULTS: A chip was used to measure 92 protein biomarkers

Background: Home care underwent abrupt adaptations to handle the COVID-19 pandemic including an accelerated digitalization. While some research exists regarding the working conditions for home care personnel during the COVID-19 pandemic, few studies exist on the effect of everyday technology use in home care during the pandemic. The aim of this study was to investigate how digital technologies, in

PURPOSE: Several studies have indicated that broad genomic characterization of childhood cancer provides diagnostically and/or therapeutically relevant information in selected high-risk cases. However, the extent to which such characterization offers clinically actionable data in a prospective broadly inclusive setting remains largely unexplored.METHODS: We implemented prospective whole-genome seq

Sedimentary molybdenum (Mo) and uranium (U) enrichments are often used as redox proxies to reconstruct bottom water redox changes. However, these redox proxies may not be equally reliable across a range of coastal settings due to varying depositional environments. Fjords vary greatly in their depositional conditions, due to their unique bathymetry and hydrography, and are highly vulnerable to anth

In this chapter, we will lay the foundation for the case studies in the subsequent chapters. To this end, we will make explicit our understanding of populism, which links the individual contexts discussed in the remainder of this book. In this book, we define populism as a political strategy and/or practice, realised in discourse, that is based on a dichotomy between "the people", who are unified

Denna avhandling handlar om hur arkitektur producerar normer genom hållbar stadsutveckling, från formulering av visioner och strategier till materialisering och design. Den handlar också om arkitekturens potentiella roll i att omförhandla och utmana den normativt utstakade vägen framåt, till förmån för alternativa förhållningssätt. Hållbar stadsutveckling beskrivs i avhandlingen som en typologi avArchitecture, planning and urban design are some of the professional practices that contribute to the spatial aspects of societal organization and enable everyday life to run smoothly. The urgent and intertwined challenges of climate change and social injustice have introduced new dimensions to these tasks, frequently framed as working towards ‘sustainable development.’ In this doctoral thesis, I

The prospect of being able to efficiently inject large plasmids in insulin-producing beta cells is very attractive for diabetes research. However, conventional transfection methods suffer from high cytotoxicity or low transfection efficiency, which negatively affect their outcome. In contrast, nanostraw electroporation is a gentle method that can provide a high transfection efficiency while mainta

Allt eftersom behandlingar för neurodegenerativa sjukdomar utvecklas, har tidig identifiering av kognitiv försämring blivit allt viktigare för att kunna påbörja en snabb intervention och bedöma behandlingens effektivitet. Denna avhandling undersöker olika aspekter av kognitiv testning relaterad till neurokognitiva störningar.Introduction: It is important to understand how to interpret and utilize cognitiveassessment results for diagnosis, treatment, and inclusion in clinical studies. Astreatments for neurodegenerative diseases advance, the need to identify cognitivedecline in its earliest stages is becoming increasingly important, both for the timelyinitiation of treatment and for assessing the efficacy of interventio

Background: Modern drug-eluting stents have seen significant improvements, yet still create a rigid cage within the coronary artery. There is a 2% to 4% annual incidence of target lesion failure (TLF) beyond 1 year, and half of the patients experience angina after 5 years. The DynamX bioadaptor is a sirolimus-eluting, thin (71 µm) cobalt-chromium platform with helical strands that unlock and separ