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Metabolomics is a rapidly growing research field. It aims for quantification of all the metabolites in a biological sample such as plasma, saliva, cerebrospinal fluid or cells. Because the metabolite levels in a biological sample are the end result of the regulatory processes in cells, metabolomics is a very powerful approach for characterisation of phenotypes. Metabolomics has been used to find d
During the prolonged course of chronic viral infection there is a continuous reciprocal interaction between the host immune defence system and the viral immunogens, and viral genetic mutations capable of circumventing host immune defence could be selected for. Our observation of increasing prevalence of heterogeneity in the DNA sequence coding for the ‘a1 determinant of HBsAg in patients with pres
It is the aim of this thesis to contribute to a research-based understanding of researchers’ use of blogs as a part of scholarly communication. The following research questions guide the investigation: (1) How are scholarly blogs constructed and used as sociotechnical systems in scholarly communication? (2) Which roles do scholarly blogs play in relation to other forms of scholarly communicati
Dyslipidemia is a chronic deviation from normal blood lipid levels that can lead to atherosclerosis and other cardiovascular diseases; dyslipidemia and its sequelae are caused by the complex interplay of genetic and environmental factors. Although circulating concentrations of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein chole
På senare år har sjukdomspanoramat för hjärtsjukdomar förändrats, med sjunkande insjuknande och dödlighet i hjärtinfarkt men stigande insjuknande i förmaksflimmer och hjärtsvikt. Förmaksflimmer är den vanligaste hjärtrytmrubbningen och medför ökad risk för uppkomst av blodproppar i hjärtat som kan resultera i stroke, demens och förtida död. Symptom på förmaksflimmer är hjärtklappning, trötthet, anBackground: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and increases in prevalence. As AF confers increased risk of morbidity, stroke, dementia and mortality, a major objective of cardiovascular epidemiology today is the development of tools for prediction and prevention of AF and its consequences. Although AF has traditionally been considered a non-heritable disease,
The Struggle for High and Low Culture. Studies in the Late Twentieth Century Novel’s Relationship to Mass Culture and Modernity. It is a widespread opinion that the boundaries between high culture and mass culture have become less defined in our postmodern culture. How is the aesthetic exchange to be interpreted between cultural spheres – high and low respectively – long considered incompatible?
The working life of today is characterized by a changing environment with heavier workload, lack of control, temporary work contracts and decreased workplace support. In recent years there has been a growing interest in studying the impact of insecure employment and several studies show that organizational changes and downsizing have negative consequences for the employees. Some authors argue that
As the knowledge about anthropogenic impacts of climate change has grown, the awareness of the contributions from treatment of wastewater has widened the scope for wastewater treatment plants (WWTPs). Not only shall ever stricter effluent constraints be met, but also energy efficiency be increased, greenhouse gases mitigated and resources recovered. All under a constant pressure on costs. The main
IMPORTANCE Low-density lipoprotein cholesterol (LDL-C)-lowering alleles in or near NPC1L1 or HMGCR, encoding the respective molecular targets of ezetimibe and statins, have previously been used as proxies to study the efficacy of these lipid-lowering drugs. Alleles near HMGCR are associated with a higher risk of type 2 diabetes, similar to the increased incidence of new-onset diabetes associated w
Background: Many individuals with a spinal cord injury (SCI) have lived several decades with their injury, leading to a need for a deeper understanding of factors associated with healthy aging in people with long-term SCI. Objectives: To (1) describe secondary health conditions, activity limitations, and life satisfaction in older adults with long-term SCI, and to (2) investigate how sociodemograp
Background: Current guidelines recommend androgen deprivation therapy only for men with very high-risk prostate cancer (PCa), but there is little evidence to support this stance. Objective: To investigate the association between radical local treatment and mortality in men with very high-risk PCa. Design, setting, and participants: Semiecologic study of men aged <80 yr within the Prostate Cancer d
OBJECTIVE(S):: We explored incidence, predictors, and long-term prognosis of hospital admissions attributed to reflex syncope and orthostatic hypotension. METHODS:: We analyzed a cohort of 32?628 individuals (68.2% men; age, 45.6?±?7.4 years) without prevalent cardiovascular disease over a follow-up period of 26.6?±?7.5 years. RESULTS:: One thousand and fourteen persons (3.1%, 1.2 per 1000 person-
Due to the scarcity of reliable and highly resolved moisture proxies covering much of the Holocene, there has been increased interest in the study of living and subfossil peatland trees sensitive to gradual and extreme chang- es in hydrology, precipitation, and related environmental processes. Peatland development and the associated carbon accumulation, which are strongly influenced by hydrologicaDue to the scarcity of reliable and highly resolved moisture proxies covering much of the Holocene, there has been increased interest in the study of living and subfossil peatland trees sensitive to gradual and extreme changes in hydrology, precipitation, and related environmental processes. Peatland development and the associated carbon accumulation, which are strongly influenced by hydrological
The overall aim of this thesis was to investigate formal care and services at home, regarding structure, process, and outcomes, for persons with dementia (aged 65+ years) at risk of nursing home admission. Availability and utilization of formal care and services at home for persons with dementia, from diagnosis to end-of-life stage, in eight European countries was described in study I. A mapping f
