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Objective: Mitochondria are involved in cellular metabolism, energy production, calcium homeostasis, and the synthesis of sterols and bile acids (BAs). Emerging evidence suggests that mitochondrial dynamics including biogenesis, fusion, fission, and mitophagy critically influence cardiometabolic diseases, yet their role in atherogenesis remain poorly understood. Mitochondrial fusion ensures metabo

Background: Patients with diabetes admitted to emergency care face a higher risk of complications, including prolonged hospital stays, admissions to the intensive care unit and mortality. Aim: To develop a machine learning (ML) model to predict 30-day mortality in patients with diabetes admitted to the emergency department (ED). Design and setting: A cohort study utilizing data from all nine ED’s

Background: Amyotrophic lateral sclerosis (ALS) is invariably fatal but there are large variations in the rate of progression. The lack of predictability can make it difficult to plan clinical interventions. This includes the requirement for gastrostomy where early or late placement can adversely impact quality of life and survival. Methods: We designed a model to predict the timing of gastrostomy

BACKGROUND: Atrial fibrillation (AF) often complicates ST-segment–elevation myocardial infarction (STEMI), but data on AF recurrence after first-ever AF during STEMI are scarce. We aimed at assessing the risk of AF recurrence after first-ever transient AF during admission for STEMI. METHODS: We performed a single-center, register-based cohort study. Patients with STEMI discharged alive after prima

Transfecting clonal beta cells with large DNA plasmids holds significant promise for diabetes research. Existing transfection techniques like lipofection, viral transduction, and bulk electroporation often face limitations such as low efficiency and cytotoxicity. Nanoelectroporation, which utilizes nanopores or nanostraws and the application of mild electrical pulses, offers a gentle and safe alte

Background Self-harm is a prevalent health concern among youths, with significant psychosocial impacts on both youths and their parents. The aim of this study is to describe the impact of offspring self-harm on parental work absence. Methods This cohort study included 176 472 mothers and 161833 fathers of 17 726 youths with a first self-harm diagnosis between the years of 2006 and 2016 and 177 260

Syftet med detta arbete är att undersöka om rullande bärighetsmätningar RWD är ett alternativ till fallviktsmätningar FWD i arbetet kring vägbärighet i vägprojekt. Bärighet beskrivs av Trafikverket som ” Den högsta last, enstaka eller ackumulerad, som kan accepteras med hänsyn till uppkomst av sprickor eller deformationer”. Det vill säga hur tunga fordon en väg eller en bro kan belastas med s

It is predicted that continentality, a climate parameter representative of a region’s annual temperature and precipitation range, will undergo significant changes in the future. The lack of past continentality reconstructions makes it impossible to decipher any long-term patterns of continentality changes. Here, we investigate the extent to which continentality influences modern chironomid assembl

Background: Despite considerable interest in the consequences of benzodiazepine and benzodiazepine-related Z-drug (BZDR) use, little is known about whether and how initiation of BZDR treatment relates to the development of alcohol- and drug-related problems. Aims: This study aimed to examine the association of incident BZDR dispensing with subsequent alcohol- and drug-related problems. Methods: Th

Background and aims: Animal studies have suggested that high salt intake might increase the risk of metabolic dysfunction-associated steatotic liver disease (MASLD), but results from populations are mixed, in part due to inadequate salt intake measurement. Salty taste preference is the primary factor leading to salt choice and can reflect habitual salt intake. However, no study has investigated t

Single-cell and single-nuclei RNA-sequencing (scRNA-seq and snRNA-seq) analyze cell-specific transcriptomes. However, only snRNA-seq applies to frozen biobanked samples. For human pancreatic islets, marker genes and reference-based cell type annotation methods are mainly from scRNA-seq datasets and may not be suitable for snRNA-seq. We compared human islet scRNA-seq and snRNA-seq data from the sam

Introduction: Food systems strongly influence both human and planetary health. Unhealthy diets aremajor risk factors for chronic disease and mortality, while food production contributes substantially togreenhouse gas emissions (GHGE), and other negative environmental impacts. Adopting moresustainable dietary patterns, such as the EAT-Lancet diet, has been proposed as part of the solution, butuncer

Background: Carotid atherosclerotic plaques with intraplaque hemorrhage (IPH) are associated with elevated stroke risk. IPH is predominantly imaged based on paramagnetic properties of the upstream hemoglobin degradation product methemoglobin. This is an explorative observational study to test the feasibility of a spoiled gradient echo based T2* weighted MRI sequence (3D MEDIC) for carotid plaque i

Water contamination with per- and polyfluoroalkyl substances (PFAS) is a serious problem for water suppliers in many regions. Due to persistence of the substances and a complex distribution mechanism, PFAS can have an adverse impact on water quality. Reported toxicological and health effects, make it very important to minimise the of wildlife and human exposure to PFAS. The exposure path is, howev

Background: Previous studies have proposed growth differentiation factor-15 (GDF-15) as a predictor of adverse cardiovascular outcomes and mortality. The present study aimed to determine if such associations remain after accounting for death as a competing risk, and if GDF-15 provides superior prediction performance than other biomarkers. Methods: Plasma GDF-15 levels and cardiovascular risk facto

AIMS: Detecting changes in ventricular function after orthotopic heart transplantation (OHT) using transthoracic echocardiography (TTE) is important but interpretation of findings is complicated by lack of data on early graft adaptation. We sought to evaluate echocardiographic measures of ventricular size and function the first year following OHT including speckle tracking derived strain. We also

Objective: Hyponatremia is the most common electrolyte imbalance. The initial treatment decision is based on clinical evaluation of patient volume status but an accurate assessment is difficult, particularly differentiating mild hypovolemia from euvolemia. The aim of this study is to examine if biomarkers are valuable in the early determination of volume status and SIADH diagnosis. Methods: Blood