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The prospect of being able to efficiently inject large plasmids in insulin-producing beta cells is very attractive for diabetes research. However, conventional transfection methods suffer from high cytotoxicity or low transfection efficiency, which negatively affect their outcome. In contrast, nanostraw electroporation is a gentle method that can provide a high transfection efficiency while mainta
Denna avhandling handlar om hur arkitektur producerar normer genom hållbar stadsutveckling, från formulering av visioner och strategier till materialisering och design. Den handlar också om arkitekturens potentiella roll i att omförhandla och utmana den normativt utstakade vägen framåt, till förmån för alternativa förhållningssätt. Hållbar stadsutveckling beskrivs i avhandlingen som en typologi avArchitecture, planning and urban design are some of the professional practices that contribute to the spatial aspects of societal organization and enable everyday life to run smoothly. The urgent and intertwined challenges of climate change and social injustice have introduced new dimensions to these tasks, frequently framed as working towards ‘sustainable development.’ In this doctoral thesis, I
Background: Modern drug-eluting stents have seen significant improvements, yet still create a rigid cage within the coronary artery. There is a 2% to 4% annual incidence of target lesion failure (TLF) beyond 1 year, and half of the patients experience angina after 5 years. The DynamX bioadaptor is a sirolimus-eluting, thin (71 µm) cobalt-chromium platform with helical strands that unlock and separ
BACKGROUND: Programmed death-ligand 1 (PD-L1) expression on tumor cells is associated with poor prognosis in several malignancies, while partly contradictory and inconclusive results have been presented for colorectal cancer (CRC). This study aimed to evaluate PD-L1 as a prognostic biomarker in CRC by comparing three different antibody clones.METHODS: Patients surgically treated for CRC between Ja
Allt eftersom behandlingar för neurodegenerativa sjukdomar utvecklas, har tidig identifiering av kognitiv försämring blivit allt viktigare för att kunna påbörja en snabb intervention och bedöma behandlingens effektivitet. Denna avhandling undersöker olika aspekter av kognitiv testning relaterad till neurokognitiva störningar.Introduction: It is important to understand how to interpret and utilize cognitiveassessment results for diagnosis, treatment, and inclusion in clinical studies. Astreatments for neurodegenerative diseases advance, the need to identify cognitivedecline in its earliest stages is becoming increasingly important, both for the timelyinitiation of treatment and for assessing the efficacy of interventio
Background: The quality of the total mesorectal excision specimen in rectal cancer surgery is assessed with a three-tier grade (mesorectal, intramesorectal and muscularis propria). This study aimed to analyse the prognostic impact of the total mesorectal excision grade on survival, and to identify risk factors for intramesorectal and muscularis propria resection in a population-based setting. Meth
Background: Epidemiological evidence on weight change and atrial fibrillation (AF) remains limited and inconsistent. Previous studies on body mass index (BMI) in youth and AF rarely considered subsequent BMI. This study aimed to assess the associations of AF with weight change and BMI in youth, as well as modified effect by genetic susceptibility of AF. Methods: The study included 21,761 individua
Importance: Electroconvulsive therapy (ECT), wherein a generalized epileptic seizure is induced, is a treatment for major depressive disorder (MDD). Currently, it is unclear whether there is an association between seizure length and treatment outcome. Objective: To explore the association between seizure duration, potential confounding variables, and ECT treatment outcome. Design, Setting, and Par
AIMS: Biomarkers associated with asymptomatic ventricular dysfunction might improve risk stratification and identify pathways leading to heart failure (HF). We explored the association between proteomic biomarkers and left ventricular hypertrophy (LVH), diastolic dysfunction (DD) and incident HF in three population-based cohorts.METHODS AND RESULTS: A chip was used to measure 92 protein biomarkers
Background: Home care underwent abrupt adaptations to handle the COVID-19 pandemic including an accelerated digitalization. While some research exists regarding the working conditions for home care personnel during the COVID-19 pandemic, few studies exist on the effect of everyday technology use in home care during the pandemic. The aim of this study was to investigate how digital technologies, in
Leapfrog migration is a common migration pattern in birds where the breeding and wintering latitudes between populations are in reversed latitudinal sequence. Competition for wintering and breeding sites has been suggested to be an ultimate factor, and several competitor-based hypotheses have been proposed to explain this pattern. If wintering sites close to the breeding sites are favored, competi
Environmental loads, such as wind and river flow, play an essential role in the structural design and structural assessment of long-span bridges. Climate change and extreme climatic events are threats to the reliability and safety of the transport network. This has led to a growing demand for digital twin models to investigate the resilience of bridges under extreme climate conditions. Kalix bridg
Aims/hypothesis: The temporal suppression of insulin clearance after glucose ingestion is a key determinant of glucose tolerance for people without type 2 diabetes. Whether similar adaptations are observed after the ingestion of a mixed-macronutrient meal is unclear. Methods: In a secondary analysis of data derived from two randomised, controlled trials, we studied the temporal responses of insuli
