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BACKGROUND: – Proteins linked to heritable coronary heart disease (CHD) could uncover new pathophysiological mechanisms of atherosclerosis. We report on the protein profile associated with a family history of early-onset CHD and whether the relation between proteins and coronary atherosclerotic burden differs according to family history status, as well as inferences from Mendelian randomization. M
Polyunsaturated fatty acids (PUFA) have been shown to reduce liver fat compared to saturated fat, but effects of a novel “anti-lipogenic” diet replacing carbohydrates with PUFA (LCPUFA) or a low-fat healthy Nordic diet (HND) rich in whole-grains are unknown. The objective of this study was to investigate the effects of these diets, as compared with usual care (UC), on liver fat (primary outcome) a
BACKGROUND: Homologous recombination deficiency (HRD) originating from inactivation of genes like BRCA1/BRCA2 is a targetable abnormality common in triple-negative breast cancer (TNBC). In estrogen-receptor (ER)-positive HER2-negative (ERpHER2n) breast cancer (BC), HRD prevalence and clinical impact are unclear.METHODS: We analyzed 502 ERpHER2n tumors from patients recruited via the population-rep
Skeletal muscle capillary density is correlated with physical performance and whole-body metabolic properties. Thus, we performed a genome-wide association study of skeletal muscle capillary-to-fiber ratio (C:F) (n = 603 males) and found that the rs115660502 G allele was associated (p < 5 × 10 -8) with increased C:F and reduced skeletal muscle expression of RAB3 GTPase-activating non-catalytic p
BackgroundUmbilical cord arterial pH (UApH) is the most objective measurement of the metabolic condition of the infant at birth. However, studies have identified changes in UApH with advancing gestational age, as there is limited data examining UApH changes with different modes of birth. The objective was to establish reference values for UApH according to mode of birth and to investigate the infl
Introduction: Implementing new treatment regimens entails a learning phase with a concomitant risk of suboptimal results. High caseload has generally been shown to improve results in complex surgical procedures. This study aimed to evaluate results of Cytoreductive Surgery (CRS) and Intraperitoneal Chemotherapy (IP), given as Early Postoperative Intraperitoneal Chemotherapy (EPIC) or Hyperthermic
BACKGROUND: Global longitudinal strain (GLS) and left atrial strain metrics, including reservoir (LAr), contraction (LAct), and conduit strain (LAcd), have emerged as key indicators of left ventricular (LV) function and filling pressures. However, the prognostic value of these markers for risk stratification in acute heart failure (HF) remains uncertain, particularly in identifying patients at ele
Background: In addition to impairing the lung function, chronic obstructive pulmonary disease (COPD) also affects phonatory characteristics. Recent research highlights the potential of voice as a digital biomarker to support clinical decision-making. While machine learning (ML) can detect disease patterns from acoustic features, clinical relevance requires understanding the relationship between th
The world today stands at a cross roads when it comes to energy and electrical grids. A large part of the worlds population still lacks access to reliable working electricity 24 hours a day. Much of this is in remote and poor parts of the world. For much of the 20th century large centralized AC grids have been the norm to provide people with electricity. But for remote parts of the world including
Denna uppsats behandlar framtida utfästelser att överlåta fast egendom och i synnerhet ersättningsklausuler som kopplats till utfästelsen. Framtida utfästelser att överlåta fast egendom har ingen rättsverkan på så sätt att en överlåtelse inte kan framtvingas. Som huvudregel kan heller inte en part som drar sig ur åläggas att betala skadestånd. Den part som ändå vill sätta press på sin motpart kan This paper deals with future commitments to transfer immovable property and especially compensation clauses connected to the commitment. Future commitments to transfer immovable property has no legal effect, a party can not enforce transfer. Nor can a party be required to pay damages. A party that wants to put pressure on its counterpart can induce a special commitment to replace possible damages.
Syftet med denna uppsats är att redogöra för gällande rätt kring utevarohandläggning i brottmål samt närmare belysa den problematik som kan uppkomma vid handläggningen. Detta sker med hjälp av den rättsdogmatiska metoden. En stor del av uppsatsen riktar in sig på frågan om rätten kan utreda saken tillfredsställande samt utföra en ändamålsenlig bevisvärdering om den tilltalade inte är närvarande viThe purpose of this essay is to examine the law of trial in the absence of the defendant in criminal cases (trial in absentia) and illuminate the complex of problems that can arise during processing. This is done by using the legal dogmatic method. A substantial part of the paper addresses the question of whether the court can investigate the case satisfactorily and carry out an appropriate evalua
Purpose – The purpose of this thesis is to investigate the impact of gender neutral communication on brand image. Methodology – This study was conducted using the experimental design framework of pre- post random group. The respondents were assigned into two groups: control and intervention. In the control group the respondents were shown a gender stereotyped advertising and the intervention grou
Lagen (1982:80) om anställningsskydd, är den lag som torde vara av störst betydelse när det kommer till anställningar. Den reglerar bl.a hur en anställning ingås, vilka anställningsformer som finns och regler kring hur en anställning upphör. Från lagens tillämpningsområde undantas bl.a. personer med en företagsledande ställning och arbetsgivarens familjemedlemmar. Undantagen har motiverats med att
How to best organize the social services unit of individual and family care (IFO) has been in question since the 1980ies. Two principal ways of organization have been used, called integrated and specialized organization. In an integrated organization, the social secretary works with all parts of the clients' problem picture. This structure used to be the norm but is today only employed by a fe
One way for manufacturing companies to gain competitive advantage in today’s business environment is to complement the product offering with surrounding services that deliver superior value to the customer. Further, the demand for these surrounding services is influenced by market-specific customer requirements, surrounding competitive environment and local prerequisites. Therefore, there is a nee
