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Din sökning på "swedish" gav 92152 sökträffar

Self-reported physical activity more than 1 year after stroke and its determinants in relation to the WHO recommendations

BACKGROUND: Physical activity (PA) after stroke has significant health benefits if it is conducted regularly, with sufficient intensity and duration. Because of the health benefits, it is important to identify those below the World Health Organization (WHO) recommended level of PA. However, few studies have assessed the level of PA after stroke in relation to the WHO recommendations and which soci

Moonlighting complement inhibitors and their link to human diseases

Breast cancer and type 2 diabetes are major health concerns worldwide. This thesis has focused on novel non-canonical roles of two complement inhibitors, which led to the discovery of new mechanisms and factors at play in these diseases. The sushi domain-containing protein 4 (SUSD4) was previously portrayed as a breast cancer suppressor, but no mechanism was identified. In paper I, using a syngene

18 F-FDG-PET/CT in breast cancer imaging : Restaging and Implications for treatment decisions in a clinical practice setting

Background and purpose: Although the diagnostic accuracy of 18F-fluorodeoxyglucose – positron emission tomography/computed tomography (18F-FDG-PET/CT) for breast cancer (BC) has been well studied, few studies have evaluated the impact of 18F-FDG-PET/CT on BC patient care. This study aimed to investigate restaging and 18F-FDG-PET/CT-induced changes in clinical decision-making in patients with BC. M

Drug-Coated Balloons Versus Drug-Eluting Stents or Plain Old Balloon Angioplasty : A Long-Term in-Stent Restenosis Study

BACKGROUND: Balloon angioplasty with drug-coated balloons (DCBs) is frequently used during percutaneous coronary intervention for in-stent restenosis. Despite its frequent use, there is a lack of long-term data on the efficacy of DCB angioplasty. We conducted an investigation on the long-term efficacy outcome of in-stent restenosis, comparing DCBs, drug-eluting stents, and plain old balloon angiop

A strategic perspective on automated warehouse systems in retail : Insights from a multiple case study

PurposeAs the warehouse is increasingly viewed as a strategic component, retailers’ willingness to invest in automated warehouse systems (AWS) has increased. These investment decisions are influenced by well-known operational factors, but strategic factors, which have received limited attention in warehousing literature, also play a pivotal role. Addressing this gap, this study investigates how st

Reservoir-excess pressure parameters are independently associated with NT-proBNP in older adults

AIMS: Parameters derived from reservoir-excess pressure analysis have been demonstrated to predict cardiovascular events. Thus, altered reservoir-excess pressure parameters could have a detrimental effect on highly-perfused organs like the heart. We aimed to cross-sectionally determine whether reservoir-excess pressure parameters were associated with N-terminal pro-brain-type natriuretic peptide (

Improving hydrological modelling in cold regions using satellite remote sensing and machine learning techniques

Water resources are fundamental to life, ecosystems, and human development. In an era of climate change and increasing water scarcity, effective management of these resources is crucial, particularly in cold regions where glaciers and snow play vital roles in hydrological cycles. Understanding and accurately modelling these complex systems is essential for sustainable water resource management, cl

The CNS relapse in T-cell lymphoma index predicts CNS relapse in patients with T- and NK-cell lymphomas

Little is known about risk factors for central nervous system (CNS) relapse in mature T-cell and natural killer cell neoplasms (MTNKNs). We aimed to describe the clinical epidemiology of CNS relapse in patients with MTNKN and developed the CNS relapse In T-cell lymphoma Index (CITI) to predict patients at the highest risk of CNS relapse. We reviewed data from 135 patients with MTNKN and CNS relaps

Deep learning analysis of serial digital breast tomosynthesis images in a prospective cohort of breast cancer patients who received neoadjuvant chemotherapy

Purpose: Different imaging tools, including digital breast tomosynthesis (DBT), are frequently used for evaluating tumor response during neoadjuvant chemotherapy (NACT). This study aimed to explore whether using artificial intelligence (AI) for serial DBT acquisitions during NACT for breast cancer can predict pathological complete response (pCR) after completion of NACT. Methods: A total of 149 wo

No recovery of soil respiration four years after fire and post-fire management in a Nordic boreal forest

The long-term carbon storage capacity of the boreal forest is under threat from the increasing frequency and intensity of wildfires. In addition to the direct carbon emissions during a fire, the burnt forest often turns into a net carbon emitter after fire, leading to large additional losses of carbon over several years. Understanding how quickly forests recover after a fire is therefore vital to

The (im)possibilities of circular consumption : Producing and performing circular clothing consumption in retail and household settings

I cirkulära ekonomier förväntas konsumenter förlänga produkters livslängd och säkerställa att de återvinns—en betydande omställning från dagens ekonomiska system där linjära konsumtionssätt dominerar. För att stödja denna omställning behöver vi förstå hur cirkulär konsumtion (o)möjliggörs i olika kontexter som formats av linjär konsumtion, t. ex. detaljhandeln och hushåll. Syftet med denna avhandlIn circular economies, consumers are expected to extend product lifetimes and ensure recycling—a considerable departure from the linear take-make-dispose model. To support this shift, we need to understand how circular consumption is currently enabled in retail markets and how consumers navigate these tasks. Thus, in this dissertation, I aim to explore and conceptualise how circular consumption is

Healthcare Professionals’ Ratings and Views of Person-Centred Care in the Context of Allogeneic Hematopoietic Stem Cell Transplantation

Introduction: Allogeneic stem cell transplantation (allo-HCT) involves a long trajectory with high risk of complications. In person-centred care (PCC), patients’ needs, resources and the care relationship are central to the care process. Healthcare professionals’ (HCPs) ratings of PCC have not previously been investigated in this context. Objectives: The aim of this study was to investigate health

Comparison of Self-Reported Physical Activity between Survivors of Out-of-Hospital Cardiac Arrest and Patients with Myocardial Infarction without cardiac arrest : a case-control study

AIMS: To investigate whether out-of-hospital cardiac arrest (OHCA) survivors had lower levels of self-reported physical activity compared to a non-cardiac arrest control group with myocardial infarction (MI), and to explore if symptoms of anxiety, depression, kinesiophobia (fear of movement) and fatigue were associated with a low level of physical activity.METHODS: Predefined case-control sub-stud

The Effects of Calorie Restriction and Bariatric Surgery on Circulating Proneurotensin Levels

Context: Proneurotensin (pNT) is associated with obesity and type 2 diabetes (T2D), but the effects of Roux-en-Y gastric bypass (RYGB) on postprandial pNT levels are not well studied. Objective: This work aimed to assess the effects of RYGB vs a very low-energy diet (VLED) on pNT levels in response to mixed-meal tests (MMTs), and long-term effects of RYGB on fasting pNT. Methods: Cohort 1: Nine no

Comorbidities in childhood atopic dermatitis : A population-based study

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that is associated with allergic comorbidities. However, studies examining comorbidities in childhood AD are incomplete, which may contribute to suboptimal care. Objective: The objective was to compare the risk of developing different allergic and non-allergic comorbidities among children with AD to that of a matched non-AD

Precision prognostics for cardiovascular disease in Type 2 diabetes : a systematic review and meta-analysis

BACKGROUND: Precision medicine has the potential to improve cardiovascular disease (CVD) risk prediction in individuals with Type 2 diabetes (T2D).METHODS: We conducted a systematic review and meta-analysis of longitudinal studies to identify potentially novel prognostic factors that may improve CVD risk prediction in T2D. Out of 9380 studies identified, 416 studies met inclusion criteria. Outcome

Epigenome-wide association study of DNA methylation in maternal blood leukocytes with BMI in pregnancy and gestational weight gain

Objectives: We aimed to discover CpG sites with differential DNA methylation in peripheral blood leukocytes associated with body mass index (BMI) in pregnancy and gestational weight gain (GWG) in women of European and South Asian ancestry. Furthermore, we aimed to investigate how the identified sites were associated with methylation quantitative trait loci, gene ontology, and cardiometabolic param