Background/Aim: Type 1 diabetes is an autoimmune disease that involves the development of autoantibodies against pancreatic islet beta-cell antigens, preceding clinical diagnosis by a period of preclinical disease activity. As screening activity to identify autoantibody-positive individuals increases, a rise in presymptomatic type 1 diabetes individuals seeking medical attention is expected. Curre

The depletion of disruptive variation caused by purifying natural selection (constraint) has been widely used to investigate protein-coding genes underlying human disorders 1–4, but attempts to assess constraint for non-protein-coding regions have proved more difficult. Here we aggregate, process and release a dataset of 76,156 human genomes from the Genome Aggregation Database (gnomAD)—the larges

Anthropogenic nitrogen (N) deposition and fertilization in boreal forests frequently reduces decomposition and soil respiration and enhances C storage in the topsoil. This enhancement of the C sink can be as strong as the aboveground biomass response to N additions and has implications for the global C cycle, but the mechanisms remain elusive. We hypothesized that this effect would be associated w

Hydrological modeling realism is a central research question in hydrological studies. However, it is still a common practice to calibrate hydrological models using streamflow as a single hydrological variable, which can lead to large parameter uncertainty in hydrological simulations. To address this issue, this study employed a multi-variable calibration framework to reduce parameter uncertainty i

Uppsatsens titel: Granskning av hållbarhetsredovisningar – Varför granskar endast ett fåtal icke-statligt ägda företag hållbarhetsredo-visningen? Seminariedatum: 30 maj 2012 Ämne/kurs: FEKN90, Examensarbete magisternivå, 30 hp. Författare: Therese Solem & Pauline Svensson Handledare: Amanda Tan-Sonnerfeldt Fem nyckelord: Hållbarhetsredovisning, triple bottom line, tredje-parts gransTitle: Assurance on sustainability reports – Why there are only a few non-states owned companies that assure their sustain-ability reports? Seminar date: May 30, 2012 Course: Master thesis in business administration, 30 University Credit Points (30 ECTS). Authors: Therese Solem & Pauline Svensson Advisor: Amanda Tan-Sonnerfeldt Five key words: Sustainability reporting, triple bottom

Purpose: The purpose of this study is to investigate the value creation for acquiring firms resulting from an M&A depending on which motive lies behind, revenue and/or cost synergies. Methodology: We have conducted a quantitative study including a quantitative content analysis of press releases to identify synergy motives. The event study methodology and the market model have been used to calc

Uppsatsen redogör för rättsreglerna kring omplacering och turordning vid arbetsbristuppsägningar. Det finns ett omfattande regelverk kring anställningsskyddet i Sverige. Det reglerar hur arbetsgivare ska uppträda då uppsägningar ska äga rum. Det krävs saklig grund för att en arbetsgivare ska ha rätt att säga upp en arbetstagare. Detta framgår tydligt ur 7§ anställningsskyddslagen. För att saklig

Studien undersökte beslutsfattandestilar enligt General Decision Making Styles Inventory – GDMS, (Scott & Bruce 1995), social önskvärdhet med Social Desirability Scale– MC-SDS, Mar-lowe and Crowne (1960), tvivel kring den egna bedömningsförmågan enligt Jugdmental Self-doubt Scale – JSDS, (Mirels et al., 2002), beslutsfattandedimensioner enligt Melbourne Decision Making Questionnare – MDMQ, (MaThe study investigated decision making styles according to the General Decision Making Styles Inventory – GDMS, (Scott & Bruce 1995) social desirability was measured with the Social De-sirability Scale– MC-SDS, Marlowe and Crowne (1960), judgmental self-doubt was measured with the Judgmental Self-doubt Scale – JSDS (Mirels et al., 2002), dimensions of decision making with the Melbourne Decisio

AbstractIntroductionConservative treatment of acute appendicitis is gaining popularity, and identifying patients with a higher risk of recurrence is becoming increasingly important. Previous studies have suggested that older age, male sex, diabetes, appendicolith and abscess formation may be contributing factors, however, results from the adult population are inconsistent.AimThis study aims to ide

Upper-body adiposity is adversely associated with metabolic health whereas the opposite is observed for the lower-body. The neck is a unique upper-body fat depot in adult humans, housing thermogenic brown adipose tissue (BAT), which is increasingly recognised to influence whole-body metabolic health. Loss of BAT, concurrent with replacement by white adipose tissue (WAT), may contribute to metaboli

Background: The recent guidelines from the European Society of Cardiology recommends using high-sensitivity cardiac troponin (hs-cTn) in either 0/1-h or 0/2-h algorithms to identify or rule out acute myocardial infarction (AMI). Several studies have reported good diagnostic accuracy with both algorithms, but few have compared the algorithms directly. Objective: We aimed to compare the diagnostic a

CONTEXT: The 2 peaks of type 1 diabetes incidence occur during early childhood and puberty.OBJECTIVE: We sought to better understand the relationship between puberty, islet autoimmunity, and type 1 diabetes.METHODS: The relationships between puberty, islet autoimmunity, and progression to type 1 diabetes were investigated prospectively in children followed in The Environmental Determinants of Diab

Introduction: The CVA24 antigenic variant is the causal agent of epidemics of acute hemorrhagic conjunctivitis that has prevailed to date. To study the transmission dynamics and evolution of this variant, we molecularly characterized Cuban isolates obtained in 5 epidemic periods between 1986 and 2009. Methods: Using the BEAST v1.8.4 program, it was performed the phylogenetic and phylodynamic analy

Mortar extrusion during bricklaying, resulting from suboptimal workmanship, may act as a bridge linking clay brick masonry claddings and adjacent layers (e.g., insulation or weather-resistant barriers), thereby, facilitating water penetration into the adjacent layer owing to wind-driven rain (WDR). Despite the significant effect of water penetration on the hygrothermal performance of building enve

Dendrometers offer valuable insights into how tree growth responds to climatic variables and physiological processes over the course of a year. Yet, their applicability to extremely slow-growing trees, such as those in peatlands, has been limited due to the intricate and slow nature of growth, therefore rendering interpretation of results complex. In this study, we conducted a comprehensive monito

The receptor for advanced glycation endproducts (RAGE) has pro-inflammatory and pro-atherogenic effects. Low plasma levels of soluble RAGE (sRAGE), a decoy receptor for RAGE ligands, have been associated with increased risk for major adverse coronary events (MACE) in the general population. We performed a genome-wide association study to identify genetic determinants of plasma sRAGE in 4338 indivi