Importance: Electroconvulsive therapy (ECT), wherein a generalized epileptic seizure is induced, is a treatment for major depressive disorder (MDD). Currently, it is unclear whether there is an association between seizure length and treatment outcome. Objective: To explore the association between seizure duration, potential confounding variables, and ECT treatment outcome. Design, Setting, and Par

Context: Androgens are associated with metabolic risk factors in men. However, the independent impact of androgens and androgen metabolites on metabolic risk factors in men is unclear. Objective: Our objective was to determine the predictive value of serum levels of androgens and glucuronidated androgen metabolites for metabolic risk factors. Design and Study Subjects: We conducted a population-ba

With their potential to effectively address multiple urban sustainability challenges, the emerging policy discourse on nature-based solutions seeks to encourage the development of multifunctional nature for sustainable and just cities. Nature-based solutions, however, are vulnerable to co-option by powerful interests in ways that limit their contribution to a broad range of sustainability goals. RWith their potential to effectively address multiple urban sustainability challenges, the emerging policy discourse on nature-based solutions seeks to encourage the development of multifunctional nature for sustainable and just cities. Nature-based solutions, however, are vulnerable to co-option by powerful interests in ways that limit their contribution to a broad range of sustainability goals. R

The most recent and promising therapeutic strategies for inflammatory bowel disease (IBD) have engaged biologics targeting single effector components involved in major steps of the immune-inflammatory processes, such as tumor necrosis factor, interleukins or integrins. Nevertheless, these molecules have not yet met expectations regarding efficacy and safety, resulting in a significant percentage o

Background: Previous studies have shown that the ratio between alveolar volume (VA) and total lung capacity (TLC) reflects ventilation heterogeneity in subjects with chronic obstructive pulmonary disease (COPD). However, the ratio and its correlation to respiratory symptoms had to our knowledge not previously been investigated in subjects with mild chronic airflow obstruction or without airflow ob

CONTEXT: Perioperative oral carbohydrate intake is beneficial to general surgery patients. Total hip arthroplasty is a common surgical procedure, and even a moderate improvement in patient outcome could have a significant effect on the resources needed for these patients. However, few studies have focused on the effects of carbohydrate intake on orthopaedic patients. OBJECTIVE: The purpose of th

AIMS/HYPOTHESIS: To study the heritability and familiality of type 2 diabetes and related quantitative traits in families from the Botnia Study in Finland. METHODS: Heritability estimates for type 2 diabetes adjusted for sex, age and BMI are provided for different age groups of type 2 diabetes and for 34 clinical and metabolic traits in 5,810 individuals from 942 families using a variance compone

Heterocyclic amines (HAs), formed when meat and fish are cooked at high temperatures, have been linked to mammary gland cancer in rats, and some epidemiological studies indicate increased breast cancer risk by consumption of well-done meat. The epidemiological evidence linking HAs per se to breast cancer is however sparse, especially from prospective studies. Moreover, high-fat diets rich in omega

C-peptide in the classification of diabetes in children and adolescents. Aim: To report C-peptide results in newly diagnosed patients and the relation to clinical diagnosis of diabetes. Methods: A nation-wide cohort, the Better Diabetes Diagnosis study was used to determine serum C-peptide at diagnosis in 2734 children and adolescents. Clinical data were collected at diagnosis and follow-up. C-pep

PurposeThis paper aims to examine how CEO talk of sustainability in CEO letters evolves in a period of increased expectations from society for companies to increase their transition towards becoming more sustainable and to better account for progress and performance within the sustainability areas.Design/methodology/approachBy adopting an interpretive textual approach, the paper provides a careful

Populärvetenskaplig sammanfattning: Koldioxid är en viktig växthusgas. Växthusgaser fungerar som värmeisolerare i atmosfären och höjer temperaturen på jorden så att liv blir möjligt. Koldioxid utgör även en viktig del av fotosyntesen och respirationen hos jordens organismer. Sen början av den industriella revolutionen har halten koldioxid i atmosfären ökat exponentiellt. Utnyttjandet av fossila brCarbon dioxide in the atmosphere contributes to the greenhouse effect, which is essential to life on our planet. Furthermore, it plays an important part of the photosynthesis and respiration of the world’s organisms. Since the start of the industrial revolution the amount of carbon dioxide in the atmosphere has increased exponentially. The main source is the extensive burning of fossil fuels. If t

Populärvetenskaplig sammanfattning: Övergödningen av våra kustnära hav blev akut under 1980-talet, syrefria bottnar och giftiga algblomningar visade tydligt att något var mycket fel. Kväve, ett näringsämne, visade sig vara en av huvudorsakerna till dessa reaktioner i havet. De största kvävespridarna i Sverige var jordbruk och reningsverk. Avloppsvattenhanteringen behövde förändras och ett sätt att

Populärvetenskaplig sammanfattning: Flera olika klimatsimuleringar har visat på en sannolik förändring av jordens klimat, till största delen beroende på utsläpp orsakade av mänsklig aktivitet. Eftersom klimatet påverkar såväl ekosystem som livsmiljö är det av största intresse att kartlägga vilka konsekvenser en eventuell klimatförändring kan få. Även om människans vardag för det mesta påverkas av

This paper is a qualitative study on the influence of the residents in a special communitydwelling within the care system for elderly. The purpose of the study is to describe and analyse with a user perspective how particularly staff members but also a group of retired people living in this dwelling interpret and articulate the concept of resident influence. How the retirees can influence the desi

This thesis investigates all aspects of quality and evaluation issues concerning collections of Internet links in public libraries today and in the future. We have studied central theories concerning quality in general as well as quality aspects regarding the Internet and Internet links. In addition to this we have made three case-studies involving the development of collections of Internet links

Background and aim: Telomere length (TL) is a key biomarker of cellular aging, with shorter telomeres associated with age-related diseases. Lifestyle interventions mitigating telomere shortening are essential for preventing such conditions. This study aimed to examine the effects of two weight loss dietary strategies, based on a moderately high-protein (MHP) diet and a low-fat (LF) diet on TL in i