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Aims: Social science literature suggests that unlimited trust in others may lead to adverse outcomes, and that moderate trust may be more optimal in social interactions. The aim was to analyze associations between generalized trust in other people and all-cause mortality using a four-alternative generalized trust item that includes moderate trust. Study design: Prospective cohort study. Methods: T

Co-speech head and eyebrow gestures often align with pitch accents in spoken language production, thereby likely instantiating what we could refer to as multimodal prominence. Indeed, when speech is perceived audio-visually, controlled experimental studies have shown that both pitch accents and head and eyebrow gestures, when independently manipulated, have sizable effects on perceived prominence.

We investigate whether the eye parameter of bumblebees—a visual trait measuring the tradeoff between light sensitivity and visual resolution—is associated with: (i) local habitats, (ii) forest cover at the landscape scale (1 km radius), and (iii) the shade tolerance of the plants they forage on. The association of bumblebee species with local habitat and forest cover at the landscape scale was ana

Perturbed secretion of insulin and other pancreatic islet hormones is the main cause of type 2 diabetes (T2D). The islets harbor five cell types that are potentially altered differently by T2D. Whole-islet transcriptomics and single-cell RNA-sequencing (scRNAseq) studies have revealed differentially expressed genes without reaching consensus. Here, we demonstrate that further insights into T2D dis

Background and study aims Surgical resection is standard treatment of T2 rectal cancer due to risk of concomitant lymph node metastases (LNM). Local resection could potentially be an alternative to surgical treatment in a subgroup of patients with low risk of LNM. The aim of this study was to identify clinical and histopathological risk factors of LNM in T2 rectal cancer. Patients and methods This

Peatland trees are valuable archives of paleoclimatic information; however, gaps persist in understanding the relationships between tree growth, peatland hydrology, and hydroclimate variables. While previous research in peatlands has mainly focused on tree-ring widths (TRW), yielding inconclusive results, the potential of stable carbon (δ13C) and oxygen (δ18O) isotopes in tree rings remains unexpl

STUDY QUESTION Which spermatogonial differentiation states are present in prepubertal testes under normal conditions and following chemotherapy-induced depletion of spermatogonia in paediatric patients with cancer? SUMMARY ANSWER Single-cell transcriptomic analysis reveals that only undifferentiated spermatogonia are present in prepubertal boys, while differentiated states emerge during puberty, w

Boreal forests are globally important carbon (C) sinks, but strategies for maximising their climate benefit remain under debate. Major uncertainties in this discussion arise from contrasting sink-source estimates, which largely emanate from inherent limitations of standard measurement techniques to distinct spatio-temporal scales. Here, we use a spatially-nested measurement framework that integrat

Objective: Both attention-deficit/hyperactivity disorder (ADHD) and neighborhood deprivation have been previously associated with an increased risk of type 2 diabetes (T2D). However, the potential association between neighborhood deprivation and T2D in ADHD patients remains underexplored. Our aim was to study the potential effect of neighborhood deprivation on incident T2D in patients with ADHD. M

For exploring forest performance in the future, dynamic vegetation models are important tools. Tree mortality is a crucial process in these models, but explicit representations of major agents of mortality have often been relatively underdeveloped. In needle-leaved forest in the temperate and boreal zones, bark beetles are often important for the mortality pattern. The European spruce bark beetle

Evidence on the predictive ability of risk assessment models for event-free survival (EFS) in patients with pulmonary arterial hypertension is scarce. We aimed to investigate the relationship between risk status at 6 months after diagnosis (6 M) and EFS, by three risk models: Multicomponent Improvement (MCI), ESC/ERS 4-Strata Risk (4SR), and noninvasive French PH Registry Score (FRS). Data collect

Background Recent decades have witnessed tangible improvements in childhood cancer survival. However, the prognosis for children with congenital heart disease (CHD), the most prevalent birth defect, remains unclear. Due to improved survival of CHD and childhood cancer, evaluating outcomes within this intersection is important for clinical practice. We aimed to assess mortality post-cancer diagnosi

Diabetic kidney disease (DKD) is a health burden that lacks specific and early diagnostic biomarkers. For their discovery, we sequenced urinary extracellular vesicle miRNAs in a type 1 diabetes cohort of males with and without DKD. The results were replicated by sequencing or qPCR in two independent cohorts and six published datasets, including type 1 and 2 diabetes, and both sexes. We also valida

Introduction Lynch syndrome (LS) carriers have a 20-46% lifetime risk of colorectal cancer (CRC) due to mismatch repair gene variants. Mesalamine (5-ASA, 5-aminosalicylic acid), used safely in patients with ulcerative colitis, may reduce CRC risk in LS by decreasing microsatellite instability, a key driver of LS-related cancer. This study evaluates 5-ASA's efficacy as a tolerable chemopreventive d