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Type-2 diabetes (T2D) develops due to insulin resistance and an inability of the pancreatic β-cells to increase secretion of insulin and reduce elevated blood glucose levels. Diminished β-cell function and mass have been implicated in impaired β-cell secretory capacity and several microRNAs (miRNAs) have been reported to be involved in regulating β-cell processes. We believe miRNAs are nodes in im
Future generations of computing systems need to continue increasing processing speed and energy efficiency in order to meet the growing workload requirements under stringent environmental constraints. As a result, domain-specific hardware accelerators and platforms have become widely used. In addition to the conventional approach, where memory and processing elements are separated, an emerging app
The pancreatic islet is a highly structured micro-organ that produces insulin in response to rising blood glucose. Here we develop a label-free and automatic imaging approach to visualize the islets in situ in diabetic rodents by the synchrotron radiation X-ray phase-contrast microtomography (SRμCT) at the ID17 station of the European Synchrotron Radiation Facility. The large-size images (3.2 mm ×
This paper investigates the confluence of artificial intelligence (AI), the performing arts, and emotion communication, focusing on how generative AI and social robotics – today’s forefront disruptive technologies – can facilitate an exploration of emotional dynamics across artistic mediums. Drawing on the intermedial and multimodal capacities of opera, this paper presents AI-enhanced opera as a p
Introduction/objectivesInfective endocarditis (IE) caused by non-HACEK Gram-negative bacteria (nHGNB) is uncommon. In the 2023 Duke-ISCVID diagnostic criteria, Pseudomonas aeruginosa and Serratia marcescens were added as “typical” pathogens. We examine the consequences of this addition, the risk of IE in bacteremia from nHGNB species and the features of IE caused by nHGNB.Materials and methodsnHGN
Aims/hypothesisObservational studies indicate that type 2 diabetes mellitus and fasting glucose levels are associated with a greater risk for hip fracture, smaller bone area and higher bone mineral density (BMD). However, these findings may be biased by residual confounding and reverse causation. Mendelian randomisation (MR) utilises genetic variants as instruments for exposures in an attempt to a
Challenges the terrestrial focus of European prehistory, emphasizing the significance of seascapes, maritime networks, and coastal societies in shaping prehistoric Europe.For many years now, the main thrust of European prehistory has followed a fundamentally terrestrial plot line. This terrestrial paradigm has undervalued the story of Europe as a peninsula between the Baltic, Mediterranean and Atl
Emotional communication, especially through social media platforms, has become a contemporary populist threat. While this phenomenon has been studied in for example news media and social movements, we know less about its influence on civil society organizations, despite their pluralism being a centerpiece in a vibrant democracy. More specifically, we do not know if social media make civil society
Background: Electroconvulsive therapy (ECT) is an effective treatment for depression with potential transient cognitive side effects. However, subjective memory impairment can extend over a long period after ECT. Objectives: This study aimed to assess potential risk factors for long-term subjective memory impairment 6 months after ECT and to explore if the associations are mediated by depressive s
Purpose: To investigate long-term chronic postoperative inguinal pain (CPIP), QoL and recurrence in patients with a primary inguinal hernia comparing TEP to Lichtenstein. Material and methods: A questionnaire-based follow-up containing the Inguinal Pain Questionnaire (IPQ), the Cunningham Pain Scale and SF-36 was done 8 years after the TEPLICH RCT. The main objective was non-ignorable pain last we
Background: Previous studies on causative pathogens in peritonsillar abscesses have yielded varying results. However, Group A streptococci (GAS) and Fusobacterium necrophorum have been identified frequently. The aim of this study was to investigate pathogens in peritonsillar abscesses in patients tested for both ß-hemolytic streptococci and F. necrophorum, and to investigate associations between p
Objective: Stress-related mental health problems (MHP) are increasing worldwide. It has been shown that people with stress-related MHP may benefit from nature-based interventions (NBI), and equine-assisted therapy (EAT) to support their health, recovery, and activity level of daily life. However, the evidence-base to support this is still weak and there is a knowledge gap concerning health-, recov
The genetics of β-cell function (BCF) offer valuable insights into the aetiology of type 2 diabetes (T2D)1,2. Previous studies have expanded the catalogue of BCF genetic associations through candidate gene studies3–7, large-scale genome-wide association studies (GWAS) of fasting BCF8,9 or functional islet studies on T2D risk variants10–14. Nonetheless, GWAS focused on BCF traits derived from oral
Background: It is thought that patients with inborn errors of immunity (IEI) are more susceptible to severe coronavirus disease 2019 (COVID-19) than the general population, but a quantification of this potential risk is largely missing. Objective: We assessed the impact of COVID-19 on patients with IEI. Methods: A nationwide cohort study was performed to estimate the relative risk (RR) for hospita
