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Background & aims: We have previously reported that the serum levels of gut-derived tryptophan metabolite indole-3-propionic acid (IPA) are lower in individuals with liver fibrosis. Now, we explored the transcriptome and DNA methylome associated with serum IPA levels in human liver from obese individuals together with IPA effects on shifting the hepatic stellate cell (HSC) phenotype to inactiv
Background: Despite recent advances in neuroimaging and neurocritical care, severe traumatic brain injury (TBI) is still a major cause of severe disability and mortality, with increasing incidence worldwide. Antisecretory factor (AF), commercially available as Salovum®, has been shown to lower intracranial pressure (ICP) in experimental models of, e.g., TBI and herpes encephalitis. The aim of this
Extreme Value Theory (EVT) is the state-of-the-art method for proactive prediction of accident frequency from traffic interactions on a microscopic scale. The main advantage of using EVT is to predict unobserved critical events based on one or more Surrogate Measures of Safety (SMoS) (single- or multivariate EVT) through a mathematical extrapolation of extreme interactions. Such interactions are q
The spatial organisation of shopping and retail has been transformed significantly since the 1980s, commonly being conceptualised as ‘retail decentralisation.’ This shift involves the displacement of retail from town centres to out-of-town establishments and, more recently, to digital platforms, creating a noticeable vacuum. Consequently, the topic of the ‘death of town centres’ has become a signi
Electrical resistivity tomography (ERT) is a widely used technique for imaging subsurface resistivity distributions, but conventional data acquisition strategies face trade-offs between resolution, efficiency, and data quality. Comprehensive datasets that maximize subsurface information are impractical to measure directly, motivating the development of ERT data reconstruction approaches that can g
Cardiovascular-kidney-metabolic (CKM) syndrome affects approximately 90% of US adults, arising from the convergence of metabolic dysfunction, chronic kidney disease (CKD), and cardiovascular disease (CVD). These conditions create self-reinforcing cycles of multiorgan damage, substantially increasing mortality risk. The American Heart Association’s 2023 staging framework stratifies CKM from stage 0
Denna rapport analyserar framväxten av hundvänlig turism i Sverige och belyser dess betydelse för besöksnäringens utveckling. Studien visar att hunden i allt högre grad betraktas som en familjemedlem, vilket påverkar resenärers beteenden, val av destination och konsumtionsmönster. Hundägare utgör en reseaktiv och kommersiellt attraktiv målgrupp som främst reser inom Sverige och efterfrågar naturba
Habitat loss and nutrient enrichment are major drivers of plant species declines. However, local extinction risks vary widely and are shaped by life-history trait syndromes. Genomic life-history traits, which are simple, stable and widely available, offer a promising yet underexplored approach to improving extinction risk assessments and informing conservation efforts. Using a spatial comparison a
The 1990s were significant for several events promoting environmental protection and the sustainable use of natural resources. For instance, both the United Nations Conference on Environment and Development in 1992, which stressed the need to stop the overconsumption of natural resources and the United Nations Framework Convention on Climate Change endorsed a framework to combat climate change. Si
Biogenic volatile organic compounds (VOCs) play important roles in atmospheric chemistry, yet most studies have focused on canopy emissions. Decomposition of forest litter, a major below-canopy VOC source, can substantially influence atmospheric oxidation and aerosol formation. Scots pine (Pinus sylvestris L.), one of the most widely distributed tree species across the boreal zone, produces terpen
Collaborative governance networks are increasingly central to local climate action, yet research offers limited understanding of the personal, psychological, and informal factors that sustain engagement within them. This paper examines how such networks facilitate meaningful and lasting participation through an in-depth study of Malmö Works, a long-standing public–private collaboration focused on
The chemokine monocyte chemoattractant protein-1 (MCP-1) plays an important role as chemoattractant for monocytes in atherosclerosis. It is established that MCP-1 is produced by vascular smooth muscle cells, but the underlying mechanisms for its release are not identified. Here, we investigate production and secretion of MCP-1 in primary human coronary artery smooth muscle cells. We demonstrate th
Background: Increasing healthcare demands and a growing nursing shortage contribute to high workloads, psychosocial strain, and risks to care quality. Organisational conditions, job demands, and resources strongly influence nurses’ well-being, retention, and performance. Aim: To examine how nurses balance organisational demands and opportunities, and how these factors relate to work environment, w
Housing preferences in later life vary, and housing decisions are complex. While much attention has been paid to health and accessibility, less is known about how financial factors influence housing decisions among older homeowners. This qualitative study aimed to deepen understanding of how single-family homeowners aged 55 and older reason about their housing situation. We conducted focus groups
Det svenska ränteavdraget är en omdiskuterad skattepolitisk åtgärd som ofta anses bidra till både hög skuldsättning och driva upp bostadspriser, samtidigt som det underlättar för hushåll med svag ekonomi genom minskande boendekostnader. Det finns osäkerheter kring vilka ekonomiska konsekvenser som sker vid avskaffande, särskilt på lokal nivå. Ränteavdraget är ett avdrag som minskar den skatt du b
