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OBJECTIVEParalleling the rise of pediatric obesity, the prevalence of impaired glucose tolerance (IGT) and type 2 diabetes (T2D) is increasing among youth. In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating insulin secretion (TCF7L2 rs7903146, IGF2BP2 rs4402960, CDKAL1 rs7754840, HHEX rs1111875, and HNF1A rs1169288) is associated with a higher risk o

THIS STUDY IS CONCERNED with burnout and long-term sick leave, although instead of looking for several explanatory models and trying to answer the question as to why people are affected by this syndrome, the study is instead based on the idea of illness as experience. The methodology is traditionally ethnological, but with a phenomenological slant. The author makes use of an empirical material c

Background: Low adherence is a key factor in explaining impaired effectiveness and efficiency in the pharmacological treatment of hypertension. However, little is known about which factors determine low adherence in actual practice. The purpose of this study is to examine whether low social participation is associated with low adherence with antihypertensive medication, and if this association is

Objectives To ascertain whether the risk for congenital malformations is increased in pregnancies with deviating fetal growth, i.e. in those in which the estimated date of delivery (EDD) was postponed more than 1 week at the second- trimester ultrasound fetometry scan, or those suspected of intrauterine growth restriction at routine ultrasound fetometry in the third trimester. Methods The study pe

By providing nest boxes, previous studies have shown that nest sites are in short supply and limit the populations of several small passerines, including the Great Tit Parus major, the Blue Tit P. caeruleus, and the Pied Flycatcher Ficedula hypoleuca. Can this influence their distribution over a range of small woodland patch sizes in a heterogeneous landscape? To investigate this, a study was cond

Osteoprotegerin (OPG), a secreted member of the tumor necrosis factor receptor family, is a potent inhibitor of osteoclast activation and differentiation. In animal models OPG prevents bone loss, and in humans bone resorption can be reduced by injections of OPG. OPG may also play a role in cardiovascular disease since mice lacking the OPG gene display arterial calcification. In a screening effort

Plasma autoantibodies (aAbs) against the oxidized DNA base derivative 5-hydroxymethyl-2'-deoxyuridine (5-HMdU) are potential biomarkers of cancer risk and oxidative stress. We examined their association with a number of cancer risk factors: smoking, alcohol habits, body fatness, and absence of the glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) in a sample from the population-based Malmö Di

Background: Existing studies of solid cancers in rheumatoid arthritis ( RA) reflect cancer morbidity up until the early 1990s in prevalent cohorts admitted to hospital during the 1980s. Objective: To depict the cancer pattern of contemporary patients with RA, from updated risk data from prevalent and incident RA populations. To understand the risk of solid cancer after tumour necrosis factor (TNF)

Objective To explore the attitudes of obstetricians to performe a caesarean section on maternal request in the absence of medical indication. Design Cluster sampling cross-sectional survey. Setting Neonatal Intensive Care Unit (NICU) associated maternity units in eight European countries. Population Obstetricians with at least 6 months clinical experience. Methods NICU-associated maternity units w

OPENLAND3 belongs to a suite of computer programs included in the POLLSCAPE simulation model. These programs make it possible to calculate estimates of pollen loadings in lake basins or bogs using vegetation data. OPENLAND3, written in Visual Basic 6, is designed to produce appropriate vegetation data files from vegetation maps stored in a Geographical Information System. It calculates percentage