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Clinical and serological variation between patients infected with different Hepatitis B virus genotypes.

Hepatitis B virus (HBV) has eight genotypes which have distinct geographical distributions. Studies comparing differences in the clinical outcomes of infections caused by strains with genotype-related variations in the HBV genome have largely compared genotypes B and C and genotypes A and D but not all four genotypes. The present study included 196 HBV-infected patients attending an infectious dis

An economic evaluation of combination treatment with budesonide and formoterol in patients with mild-to- moderate persistent asthma

Patients with mild asthma may benefit from increasing their inhaled corticosteroid dose, adding a tong-acting beta(2)-agonist, or both. This study assessed the cost-effectiveness of these options. Patients aged greater than or equal to12 years with mild-to-moderate persistent asthma (n = 1272) were randomised to twice-daily, double-blind treatment with budesonide 100 mug, budesonide 100 mug plus f

Relationship between anti-neutrophil cytoplasmic antibody determined with conventional binding and the capture assay, and long-term clinical course in vasculitis

Objectives. To evaluate the relationship between anti-neutrophil cytoplasmic antibody (ANCA) measured with two different methods and long-term clinical course in vasculitis. Design. Retrospective determination of ANCA with two different assays for detection of PR3-ANCA, conventional direct binding ELISA and capture ELISA using monoclonal antibodies against PR3. The 245 ANCA determinations were per

PID Control, Design, Extension, Application

This thesis considers the design of PID controllers, the extensions of these controllers to improve their performance, and the applications of these design methods to industrial processes. New tuning methods for PI and PID controllers have been presented. These methods uses a model of the process to be controlled, given as a transfer function. The methods captures essential requirements of a cont

Extra-articular disease manifestations in rheumatoid arthritis: incidence trends and risk factors over 46 years

Objective: To investigate the trends in incidence of extra-articular rheumatoid arthritis (ExRA) in a well defined community based cohort of patients with rheumatoid arthritis (RA), and to examine possible predictors of ExRA occurrence. Methods: Using the resources of the Rochester Epidemiology Project, a retrospective medical record review was conducted of a cohort of 609 cases of RA in Olmsted C

The need for oncogenetic counselling - Ten years' experience of a regional oncogenetic clinic

A monogenic inheritance, mainly seen as a dominant pattern, accounts for 5 - 10% of all cancer cases. The increased knowledge and identification of high-risk genes have led to a need for specialized cancer family clinic was the expression used by Eeles and Murday. The Oncogenetic Clinic at the University Hospital in Lund was started in 1993 and the authors' 10-year experience is summarized in this