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Whilst innate B1-B cells are atheroprotective, adaptive B2-B cells are considered pro-atherogenic. Different subsets of B regulatory cells (B-reg) have been described. In experimental arthritis and lupus-like disease, B-reg are contained within the CD21(hi)CD23(hi)CD24(hi) B cell pool The existence and role of B-reg in vascular disease is not known. We sought to investigate the existence, identity
Cross-cultural translation of patient-reported outcome measures (PROMs) is a lengthy process, often performed professionally. Cognitive interviewing assesses patient comprehension of PROMs. The objective was to evaluate the usefulness of cognitive interviewing to assess translations and compare professional (full) with non-professional (simplified) translation processes.METHODS:A full protocol use
Nearly all mammalian cells express a set of genes known as clock genes. These regulate the circadian rhythm of cellular processes by means of negative and positive autoregulatory feedback loops of transcription and translation. Recent genomewide association studies have demonstrated an association between a polymorphism near the circadian clock gene CRY2 and elevated fasting glucose. To determine
1,5-Anhydro-D-fructose (AF) is a mono-saccharide directly formed from starch and glycogen by the action of alpha-1,4-glucan lyase (EC 4.2.2.13). Our previous study has indicated that AF increases glucose tolerance and insulin secretion in NMRI mice after administration through a gastric gavage in a single dose at 150 mg per mouse. In this study, we used high-fat feeding of C57BL/6J mice to examine
Objectives In this study we examined the association between leptin and blood pressure in a population-based study of Danish and Norwegian children and adolescents. Because of the putative bidirectional relationship between leptin and adiposity we formally tested (i) the mediating effect of body mass index in the association between leptin and blood pressure, and (ii) the mediating effect of lepti
Epigenetics may play a role in the pathophysiology of type 2 diabetes (T2D), and increased DNA methylation of the metabolic master regulator peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) has been reported in muscle and pancreatic islets from T2D patients and in muscle from individuals at risk of T2D. This study aimed to investigate DNA promoter methylation and gen
Background: Postprandial lipaemia varies with gender and the composition of dietary fat due to the partitioning of fatty acids between beta-oxidation and incorporation into triacylglycerols (TAGs). Increasing evidence highlights the importance of postprandial measurements to evaluate atherogenic risk. Postprandial effects of alpha-linolenic acid (ALA) in women are poorly characterized. We therefor
Objective . Intestinal ischaemia is a life-threatening condition with high mortality, and the lack of accurate and readily available diagnostic methods often results in delay in diagnosis and treatment. The aim of this study was to investigate the accuracy of different plasma biomarkers in diagnosing intestinal ischaemia. Material and methods . Prospective inclusion of patients older than 50 years
Steel is a strategic material for Europe, embedded in critical sectors such as construction, transport and defence, yet responsible for approximately 5% of EU CO2 emissions. While technological pathways for low-emission steel are advancing, their large-scale deployment depends on credible demand signals capable of supporting early market formation and reducing investment uncertainty. In response,
INTRODUCTION: Central venous catheter (CVC) insertion is frequently required in patients with haematological diseases. Despite limited evidence, thrombocytopenia often prompts prophylactic platelet transfusion before catheterisation.METHODS: We conducted an observational before-and-after study including the first non-tunnelled CVC insertion performed in adult patients with haematological diseases
Background: Older people with intellectual disabilities have complex healthcare needs, with many somatic and psychiatric co-morbidities and high healthcare utilization, including unplanned (i.e., acute) healthcare contacts. However, little is known about predictors of unplanned healthcare contacts—a possible proxy for unmet healthcare needs, particularly during the COVID-19 pandemic.Research Quest
One of the parameter in determining the level of organic contaminant in water is Biological Oxygen Demand (BOD). Its principle is the determination of the amount of the dissolved oxygen that will be utilized by aerobic microorganisms for degrading the organic matter in the wastewater. There are several approaches in measuring the BOD value, but in this study, we used the classical method, manometr
Constructing Everyday Life : A Study of Representation, Selection, and Social Ideals in Börje Hanssen’s 1940s Interview Material on the Working Class in Helsingborg During the Industrialization. This study examines how working-class everyday life in Helsingborg is portrayed in Börje Hanssen’s interview material from the 1940s, produced within the project Svensk stad: Liv och stil i svenska städer
The advance of quantum computing poses a fundamental threat to today's cryptographic systems. The American agency NIST advocates that all cryptographic systems transition to post-quantum cryptography (PQC) by 2035 and even earlier for more critical systems. Given the threat of harvest-now-decrypt-later attacks, there is a growing urgency for any system handling sensitive data to migrate to PQC
